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Hemolysin E (HlyE, ClyA, SheA) and Related Toxins

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Proteins Membrane Binding and Pore Formation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 677))

Abstract

Certain strains of Escherichia coli, Salmonella enterica and Shigella flexneri produce a pore-forming toxin hemolysin E (HlyE), also known as cytolysin A (ClyA) and silent hemolysin, locus A (SheA). HlyE lyses erythrocytes and mammalian cells, forming transmembrane pores with a minimum internal diameter of ∼25 Å. We review the current knowledge of HlyE structure and function in its solution and pore forms, models for membrane insertion, its potential use in biotechnology applications and its relationship to a wider superfamily of toxins.

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Authors and Affiliations

  1. The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, S10 2TN, UK

    Stuart Hunt, Jeffrey Green & Peter J. Artymiuk

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  1. Stuart Hunt
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  2. Jeffrey Green
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  3. Peter J. Artymiuk
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Correspondence to Peter J. Artymiuk .

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Editors and Affiliations

  1. Department of Biology, University of Ljubljana, Ljubljana, Slovenia

    Gregor Anderluh PhD

  2. Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK

    Jeremy Lakey PhD

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Hunt, S., Green, J., Artymiuk, P.J. (2010). Hemolysin E (HlyE, ClyA, SheA) and Related Toxins. In: Anderluh, G., Lakey, J. (eds) Proteins Membrane Binding and Pore Formation. Advances in Experimental Medicine and Biology, vol 677. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-6327-7_10

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