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The Immunosuppresive Tick Salivary Protein, Salpl5

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Pathogen-Derived Immunomodulatory Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 666))

Abstract

The interaction between Ixodid ticks and their mammalian hosts is a complex relationship. While the mammalian host tries to avoid the completion of the feeding process, the tick has devised strategies to counteract these attempts. Tick saliva contains a vast array of pharmacological activities that presumably aid the tick to evade host responses, including anti-complement, oxidative and innate and adaptive immune responses. The characterization of these activities has gained momentum in the last several years. One of the best studied activities present in tick saliva corresponds to the antigen known as Salpl5, which binds specifically to the T-cell coreceptor CD4 resulting in the specific repression of CD4+ T-cell activation. We discuss here the current state of our knowledge of the mode of action of this salivary protein.

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Authors and Affiliations

  1. Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, Paige Lab. 161 Holdsworth Way, Amherst, MA, 01003, USA

    Ignacio J. Juncadella & Juan Anguita

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  1. Ignacio J. Juncadella
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  2. Juan Anguita
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Correspondence to Juan Anguita .

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  1. Inflammation and Immunity Group, Institute of Molecular Medicine, Trinity College, Dublin, Ireland

    Padraic G. Fallon BSc, MSc, PhD

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Juncadella, I.J., Anguita, J. (2009). The Immunosuppresive Tick Salivary Protein, Salpl5. In: Fallon, P.G. (eds) Pathogen-Derived Immunomodulatory Molecules. Advances in Experimental Medicine and Biology, vol 666. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1601-3_10

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