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Fitting and Statistical Analysis of Single-Channel Records

  • Chapter
Single-Channel Recording

Abstract

The aims of analysis of single-channel records can be considered in two categories. The first is to allow one to observe results at leisure in order to determine their qualitative features. It may, for example, be found that the single-channel currents were not all of the same amplitude or that they showed obvious grouping into bursts or that artifacts appeared on the record that might be misleading. These effects are often not easy to see on the oscilloscope screen as an experiment proceeds. It is best to have a computer program that allows one, after the experiment, to scroll flexibly through the recorded data and zoom in on portions of the record to observe details at high time resolution.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University College London, London, WC1E 6BT, England

    David Colquhoun

  2. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA

    F. J. Sigworth

Authors
  1. David Colquhoun
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  2. F. J. Sigworth
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Editor information

Editors and Affiliations

  1. Department of Cell Physiology, Max-Planck-Institute for Medical Research, D-69120, Heidelberg, Germany

    Bert Sakmann

  2. Department of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg, D-37077, Göttingen, Germany

    Erwin Neher

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Colquhoun, D., Sigworth, F.J. (1995). Fitting and Statistical Analysis of Single-Channel Records. In: Sakmann, B., Neher, E. (eds) Single-Channel Recording. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1229-9_19

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  • DOI: https://doi.org/10.1007/978-1-4419-1229-9_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-1230-5

  • Online ISBN: 978-1-4419-1229-9

  • eBook Packages: Springer Book Archive

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