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Sex Cord-Stromal, Steroid Cell, and Other Ovarian Tumors with Endocrine, Paraendocrine, and Paraneoplastic Manifestations

  • Reference work entry
Blaustein’s Pathology of the Female Genital Tract

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Abstract

This category includes all ovarian neoplasms that contain granulosa cells, fibroblasts, theca cells (and their luteinized derivatives), Sertoli cells, Leydig cells, singly or in various combinations and in varying degrees of differentiation. Those who believe that all these cell types are derived from the “specialized stroma” of the genital ridge favor the term gonadal stromal tumors for these neoplasms [110]. Others, recognizing that many embryologists favor the participation of coelomic and mesonephric epithelium in the formation of sex cords, which are the proximal precursors of granulosa cells and Sertoli cells, favor the term sex cord-stromal tumors, and it is now the most widely accepted designation [144].

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Acknowledgment

When the late Dr. Ancel Blaustein prepared the first edition of this book in the mid-1970s, he asked Dr. Robert E. Scully to contribute the chapter on ovarian sex cord-stromal tumors and it duly appeared in 1977. In the 1980s, I had the pleasure and privilege of reviewing numerous sex cord-stromal tumors of the ovary in Dr. Scully’s remarkable collection and a number of original publications with Dr. Scully and others came to pass. This resulted in Dr. Scully asking me if I would co-author the contribution on this topic for the third edition, expanded by the inclusion of consideration of steroid cell tumors and a variety of miscellaneous other neoplasms associated with various interesting clinical manifestations. This chapter appeared in the 1987 third edition. Dr. Scully, being retired, declined to participate in this most recent reedition of the chapter and although many of the words were initially written, or edited by him, given his customary awareness of the importance of ethics in medicine, he declined to have his name associated with a work which he did not actively participate in at this time. However, I would like to acknowledge my debt to Dr. Scully for the initial chapter, which laid the groundwork for everything to follow, the opportunity to learn from his cases, and most important of all, to be educated by him on the remarkable and fascinating microscopic spectrum encountered within the family of tumors reviewed in this chapter. Similar remarks pertain to Chap. 18, Metastatics Tumors of the Ovary.

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  1. Anatomic Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Warren Bldg. 2nd Floor, Boston, MA, 02114, USA

    Robert H. Young

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  1. Departments of Gynecology, Obstetrics, Pathology and Oncology, The Johns Hopkins University School of Medicine and Director of Gynecologic Pathology, The Johns Hopkins Hospital, 401 N. Broadway, Weinberg Building Room 2242, Baltimore, MD, 21231, USA

    Robert J. Kurman (Richard W. TeLinde Distinguished Professor of Gynecologic Pathology) (Richard W. TeLinde Distinguished Professor of Gynecologic Pathology)

  2. Department of Pathology and Laboratory Medicine, Weill Cornell Medical College and New York Presbyterian Hospital, 525 East 68th Street, Starr 1015, New York, NY, 10065, USA

    Lora Hedrick Ellenson

  3. Department of Pathology, Johns Hopkins University School of Medicine, 401 N. Broadway, Weinberg Building 2242, Baltimore, MD, 21231, USA

    Brigitte M. Ronnett

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Young, R.H. (2011). Sex Cord-Stromal, Steroid Cell, and Other Ovarian Tumors with Endocrine, Paraendocrine, and Paraneoplastic Manifestations. In: Kurman, R.J., Ellenson, L.H., Ronnett, B.M. (eds) Blaustein’s Pathology of the Female Genital Tract. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0489-8_15

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