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Biomechanics of the CNS

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Mechanosensitivity of the Nervous System

Part of the book series: Mechanosensitivity in Cells and Tissues ((MECT,volume 2))

Abstract

For a long time, neurosciences have focused on biochemical, molecular, and electrophysiological aspects of cell functioning. However, there is an increasing awareness of the importance of biomechanics in physiology and pathology of the central nervous system (CNS). In the first part of this review we provide physical basics necessary to understand biomechanical measurements, we introduce the cytoskeleton as a major contributor to a cell’s passive and active mechanical behavior, and we discuss some of the methods nowadays used to quantify mechanical properties. In the second part we present actual data on CNS mechanics, and we discuss the impact of passive mechanical material properties and active mechanical behavior of cells on the development, normal functioning and pathology of the CNS.

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Acknowledgements

We would like to thank Paul Janmey, Yun-Bi Lu, and Jochen Guck for many inspiring discussions about the topic and for their continuous support.

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  1. Department of Physics, Cavendish Laboratory, Biological and Soft Systems Group, University of Cambridge, Cambridge, UK

    Kristian Franze

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  1. Kristian Franze
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  2. Andreas Reichenbach
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  3. Josef Käs
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  1. Dept. Fundamental & Applied Physiology, Russian State Medical University, Ostrovitjanova Str. 1, Moscow, Russia 117997

    Andre Kamkim  & Irina Kiseleva  & 

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Franze, K., Reichenbach, A., Käs, J. (2009). Biomechanics of the CNS. In: Kamkim, A., Kiseleva, I. (eds) Mechanosensitivity of the Nervous System. Mechanosensitivity in Cells and Tissues, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8716-5_10

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