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Formulations and Delivery Systems for Mucosal Vaccines

  • Chapter
Immunity Against Mucosal Pathogens

Abstract

Mucosal vaccines offer great advantage and better patient compliance in many disease areas. Most vaccine delivery systems are generally particulate e.g. emulsions, microparticles, iscoms and liposomes, and mainly function to target associated antigens into antigen presenting cells (APC). Several key formulation and delivery approaches exist to deliver the antigens in combination with an adjuvant by the mucosal route. Some of these have also been evaluated in the clinic while many others are still in pre-clinical evaluation. The discovery of more potent adjuvants may allow further development of prophylactic vaccines against acute infections as well as therapeutic vaccines against chronic infectious diseases, some of which could be delivered mucosally. In addition, novel and creative delivery systems may also allow vaccines to be delivered mucosally in a more efficient manner.

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Author information

Authors and Affiliations

  1. Novartis Vaccines and Diagnostics, Inc., Emeryville, CA, USA

    Manmohan Singh

Authors
  1. Padma Malyala
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  2. Manmohan Singh
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Editors and Affiliations

  1. Davis School of Medicine Department of Medical Microbiology and Immunology, University of California, Davis CA 95616, USA

    Michael Vajdy

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Malyala, P., Singh, M. (2008). Formulations and Delivery Systems for Mucosal Vaccines. In: Vajdy, M. (eds) Immunity Against Mucosal Pathogens. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8412-6_19

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