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Biomedical Applications of Functionalised Carbon Nanotubes

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Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes

Part of the book series: Carbon Materials: Chemistry and Physics ((CMCP,volume 1))

Abstract

This chapter describes the developing potential of carbon nanotubes (CNTs) in biomedicine. Methodologies to render nanotubes biocompatible, the related studies on cell uptake, applications in vaccine delivery, interaction with nucleic acids and impact on health will be described. The use of CNTs for biomedical applications is acquiring more and more substantiating evidence for efficient development. It is clear that some important issues related to the health impact including the biodistribution, accumulation and elimination have to be addressed more thoroughly before CNTs can be proposed for clinical trials. However, CNTs show remarkable carrier properties, with a very strong tendency to cross cell membranes. Although, the toxicological studies on pristine CNTs are contradictory, showing a certain degree of risk, it is becoming evident that functionalised CNTs have reduced toxic effects. Therefore, the combination of cell uptake capacity with high loading of cargo molecules achievable with CNTs makes this new carbon nanomaterial a promising candidate for innovative therapies.

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Authors and Affiliations

  1. Laboratoire d’Immunologie et Chimie Thérapeutiques, CNRS, Institut de Biologie Moléculaire et Cellulaire, 67084, Strasbourg, France

    Alberto Bianco, Raquel Sainz, Shouping Li & Hélène Dumortier

  2. Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London, WC1N 1AX, UK

    Lara Lacerda & Kostas Kostarelos

  3. School of Chemistry/Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Trinity College Dublin, College Green, Dublin 2, Ireland

    Silvia Giordani

  4. Dipartimento di Scienze Farmaceutiche, Università di Trieste, 34127, Trieste, Italy

    Silvia Giordani & Maurizio Prato

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  4. Hélène Dumortier
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  1. Lupi Chemical Research Institute, Via Casilina 1626/A, 00133, Rome, Italy

    Franco Cataldo (Director) (Director)

  2. Dipartimento di Scienze Farmaceutiche, University of Trieste, Piazzale Europe, I-34127, Trieste, Italy

    Tatiana Da Ros

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Bianco, A. et al. (2008). Biomedical Applications of Functionalised Carbon Nanotubes. In: Cataldo, F., Da Ros, T. (eds) Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. Carbon Materials: Chemistry and Physics, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6845-4_2

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