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Annexinopathies

  • Chapter
Calcium Signalling and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 45))

Abstract

Annexins comprise a conserved family of proteins characterised by their ability to bind and order charged phospholipids in membranes, often in response to elevated intracellular calcium. The family members (there are at least 12 in humans) have become specialized over evolutionary time and are involved in a diverse range of cellular functions both inside the cell and extracellularly Although a mutation in an annexin has never been categorically proven to be the cause of a disease state, they have been implicated in pathologies as diverse as autoimmunity, infection, heart disease, diabetes and cancer. ‘Annexinopathies’ were first described by Jacob H. Rand to describe the pathological sequelae in two disease states, the over-expression of annexin 2 in a patients with a haemorrhagic form of acute promyelocytic leukaemia, and the under-expression of annexin 5 on placental trophoblasts in the antiphospholipid syndrome. In this chapter we will outline some of the more recent observations in regard to these conditions, and describe the involvement of annexins in some other major causes of human morbidity

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References

  • Adlish, J.D., Lahijani, R.S., and S.C. St Jeor, 1990, Identification of a putative cell receptor for human cytomegalovirus. Virology. 176(2):337–45.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, H.C., 2003, Matrix vesicles and calcification. Curr Rheumatol Rep. 5(3):222–6.

    Article  PubMed  Google Scholar 

  • Andree, H.A., Stuart, M.C., Hermens, W.T., Reutelingsperger, C.P., Hemker, H.C., Frederik, P.M., and G.M. Willems, 1992, Clustering of lipid-bound annexin V may explain its anticoagulant effect. J Biol Chem. 267(25):17907–12.

    PubMed  CAS  Google Scholar 

  • Arnold, J., Holmes, Z., Pickering, W., Farmer, C., Regan, L., and H. Cohen, 2001, Anti-beta 2 glycoprotein 1 and anti-annexin V antibodies in women with recurrent miscarriage. Br J Haematol. 2001 113(4):911–4.

    Article  PubMed  CAS  Google Scholar 

  • Arur, S., Uche, U.E., Rezaul, K., Fong, M., Scranton, V., Cowan, A.E., Mohler, W., and D.K. Han, 2003, Annexin I is an endogenous ligand that mediates apoptotic cell engulfment. Dev Cell. 4(4):587–98.

    Article  PubMed  CAS  Google Scholar 

  • Bai, X.F., Ni, X.G., Zhao, P., Liu, S.M., Wang, H.X., Guo, B., Zhou, L.P., Liu, F., Zhang, J.S., Wang, K., Xie, Y.Q., Shao, Y.F., and X.H. Zhao, 2004, Overexpression of annexin 1 in pancreatic cancer and its clinical significance. World J Gastroenterol. 10(10):1466–70.

    PubMed  CAS  Google Scholar 

  • Bensalem, N., Ventura, A.P., Vallee, B., Lipecka, J., Tondelier, D., Davezac, N., Dos Santos, A., Perretti, M., Fajac, A., Sermet-Gaudelus, I., Renouil, M., Lesure, J.F., Halgand, F., Laprevote, O., and A. Edelman A, 2005, Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients. Mol Cell Proteomics. 4(10):1591–601.

    Article  PubMed  CAS  Google Scholar 

  • Biener, Y., Feinstein, R., Mayak, M., Kaburaqi, Y., Kadowaki, T. and Y. Zick, 1996, Annexin II is a novel player in insulin signal transduction. Possible association between annexin II phosphorylation and insulin receptor internalization. J. Biol. Chem. 271, 29489–29496.

    Article  PubMed  CAS  Google Scholar 

  • Bizzaro, N., Tonutti, E., Villalta, D., Tampoia, M., and R. Tozzoli, 2005, Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages. Arch Pathol Lab Med. 129(1):61–8.

    PubMed  Google Scholar 

  • Bolton, C., Elderfield, A.J., and R.J. Flower, 1990, The detection of lipocortins 1, 2 and 5 in central nervous system tissues from Lewis rats with acute experimental allergic encephalomyelitis. J Neuroimmunol. 29(1–3):173–81.

    Article  PubMed  CAS  Google Scholar 

  • Brownawell, A. M. and C.E. Creutz, 1997, Calcium-dependent binding of sorcin to the N-terminal domain of synexin (annexin VII). J. Biol. Chem. 272, 22182–22190.

    Article  PubMed  CAS  Google Scholar 

  • Brownlee, M., 2005, The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54, 1615–1625.

    Article  PubMed  CAS  Google Scholar 

  • Camors, E., Monceau, V., and D. Charlemagne D, 2005, Annexins and Ca2+ handling in the heart. Cardiovasc Res. 65(4):793–802.

    Article  PubMed  CAS  Google Scholar 

  • Carlstedt-Duke, J., Bronnegard, M., and B. Strandvik, 1986, Pathological regulation of arachidonic acid release in cystic fibrosis: the putative basic defect. Proc Natl Acad Sci U S A. 83(23):9202–6.

    Article  PubMed  CAS  Google Scholar 

  • Carr, G., Simmons, N.L., and J.A. Sayer, 2006, Disruption of clc-5 leads to a redistribution of annexin A2 and promotes calcium crystal agglomeration in collecting duct epithelial cells. Cell Mol Life Sci. 63(3):367–77.

    Google Scholar 

  • Cesarman-Maus, G., Rios-Luna, N.P., Deora, A.B., Huang, B., Villa, R., Del Carmen Cravioto, M., Alarcon-Segovia, D., Sanchez-Guerrero, J. and AK Hajjar, 2006, Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome. Blood. 107(11):4375–82.

    Google Scholar 

  • Cesarman, G.M., Guevara, C.A., and K.A. Hajjar, 1994, An endothelial cell receptor for plasminogen/tissue plasminogen activator (t-PA). II. Annexin II-mediated enhancement of t-PA-dependent plasminogen activation. J Biol Chem. 269(33):21198–203.

    PubMed  CAS  Google Scholar 

  • Chang, K.S., Wang, G., Freireich, E.J., Daly, M., Naylor, S.L., Trujillo, J.M., and S.A. Stass, 1992, Specific expression of the annexin VIII gene in acute promyelocytic leukemia. Blood. 79(7):1802–10.

    PubMed  CAS  Google Scholar 

  • Chapman, L.P., Epton, M.J., Buckingham, J.C., Morris, J.F., and H.C. Christian, 2003, Evidence for a role of the adenosine 5 ^′-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells. Endocrinology. 144(3):1062–73.

    Google Scholar 

  • Chatterjee, B.E., Yona, S., Rosignoli, G., Young, R.E., Nourshargh, S., Flower, R.J., and M. Perretti, 2005, Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol. 8(3):639–46.

    Article  CAS  Google Scholar 

  • Chertova, E., Chertov, O., Coren, L.V., Roser, J.D., Trubey, C.M., Bess, J.W. Jr, Sowder, R.C. 2nd, Barsov, E., Hood, B.L., Fisher, R.J., Nagashima, K., Conrads, T.P., Veenstra, T.D., Lifson, J.D., and D.E. Ott, 2006, Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. J Virol. 80(18):9039–52.

    Article  PubMed  CAS  Google Scholar 

  • Clemen, C. S., Herr, C., Hovelmeyer, N. and A.A. Noegel, 2003, The lack of annexin A7 affects functions of primary astrocytes. Exp. Cell Res. 291, 406–414.

    Article  CAS  Google Scholar 

  • Coiras M., Camafeita E., Urena T, Lopez, J.A., Caballero, F., Fernandez, B., Lopez-Huertas, M.R., Perez-Olmeda, M., and J. Alcami, 2006, Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression. Proteomics. Suppl 1:S63–73.

    Google Scholar 

  • Creutz, C. E., Pazoles, C. J. and H.B. Pollard, 1978, Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules. J. Biol. Chem. 253, 2858–2866.

    PubMed  CAS  Google Scholar 

  • Croxtall, J.D., Choudhury, Q., and R.J. Flower, 2000, Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 130(2):289–98.

    Article  PubMed  CAS  Google Scholar 

  • Croxtall, J.D., Choudhury, Q., and R.J. Flower, 1998, Inhibitory effect of peptides derived from the N-terminus of lipocortin 1 on arachidonic acid release and proliferation in the A549 cell line: identification of E-Q-E-Y-V as a crucial component. Br J Pharmacol. 123(5):975–83.

    Article  PubMed  CAS  Google Scholar 

  • Croxtall, J.D., Choudhury, Q., and R.J. Flower, 2000, Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism. Br J Pharmacol. 130(2):289–98.

    Article  PubMed  CAS  Google Scholar 

  • de Laat, B., Derksen, R.H., Mackie I.J., Roest, M., Schoormans, S., Woodhams, B.J., de Groot, P.G., and W. L. van Heerde, 2006, Annexin A5 polymorphism (-1C>T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. Ann Rheum Dis. [Epub ahead of print]

    Google Scholar 

  • de The, H., Chomienne, C., Lanotte, M., Degos, L., and A. Dejean, 1990, The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature. 347(6293):558–61.

    Article  PubMed  Google Scholar 

  • Doring, V., Veretout, F., Albrecht, R., Muhlbauer, B., Schlatterer, C., Schleicher, M. and A.A. Noegel, 1995, The in vivo role of annexin VII (synexin):characterization of an annexin VII-deficient Dictyostelium mutant indicates an involvement in Ca(2+)-regulated processes. J. Cell Sci. 108 (Pt 5), 2065–2076.

    PubMed  Google Scholar 

  • Draeger, A., Wray, S., and E.B. Babiychuk, 2005, Domain architecture of the smooth-muscle plasma membrane: regulation by annexins. Biochem J. 387(Pt 2):309–14.

    PubMed  CAS  Google Scholar 

  • Ernst, S., Lange. C., Wilbers, A., Goebeler, V., Gerke, V., and U. Rescher, 2004, An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family. J Immunol. 172(12):7669–76.

    PubMed  CAS  Google Scholar 

  • Esposito, G., Tamby, M.C., Chanseaud, Y., Servettaz, A., Guillevin, L., and L. Mouthon, 2005, Anti-annexin V antibodies: are they prothrombotic? Autoimmun Rev. 4(1):55–60.

    Article  PubMed  CAS  Google Scholar 

  • Esposito, I., Penzel, R., Chaib-Harrireche, M., Barcena, U., Bergmann, F., Riedl, S., Kayed, H., Giese, N., Kleeff, J., Friess, H., and P. Schirmacher, 2006, Tenascin C and annexin II expression in the process of pancreatic carcinogenesis. J Pathol. 208(5):673–85.

    Article  PubMed  CAS  Google Scholar 

  • Esposito, I., Penzel, R., Chaib-Harrireche, M., Barcena ,U., Bergmann, F., Riedl, S., Kayed, H., Giese, N., Kleeff, J., Friess, H., and P. Schirmacher, 2006, Tenascin C and annexin II expression in the process of pancreatic carcinogenesis. J Pathol. 208(5):673–85.

    Article  PubMed  CAS  Google Scholar 

  • Falsey, R.R., Marron, M.T., Gunaherath, G.M., Shirahatti, N., Mahadevan, D., Gunatilaka, A.A., and L. Whitesell, 2006, Actin microfilament aggregation induced by withaferin A is mediated by annexin II. Nat Chem Biol. 2(1):33–8.

    Article  PubMed  CAS  Google Scholar 

  • Fan, X., Krahling, S., Smith, D., Williamson, P., and R.A. Schlegel, 2004, Macrophage surface expression of annexins I and II in the phagocytosis of apoptotic lymphocytes. Mol Biol Cell.15(6):2863–72.

    Google Scholar 

  • Frank, K. F., Bolck, B., Ding, Z., Krause, D., Hattebuhr, N., Malik, A., Brixius, K., Hajjar, R. J., Schrader, J. & Schwinger, R. H. (2005) J. Mol. Cell Cardiol. 38, 607–615.

    Article  PubMed  CAS  Google Scholar 

  • Garcia Pedrero, J.M., Fernandez, M.P., Morgan, R.O., Herrero Zapatero, A., Gonzalez, M.V., Suarez Nieto, C., and J.P. Rodrigo, 2004, Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status. Am J Pathol. 164(1):73–9.

    PubMed  Google Scholar 

  • Gerke, V., Creutz, C. E., and S. E. Moss, 2005, Annexins: Linking Ca2+ signalling to membrane dynamics. Nat. Rev. 6: 449–461.

    Article  CAS  Google Scholar 

  • Ghitescu, L.D., Gugliucci, A., and F. Dumas, 2001, Actin and annexins I and II are among the main endothelial plasmalemma-associated proteins forming early glucose adducts in experimental diabetes. Diabetes 50, 1666–1674.

    Article  PubMed  CAS  Google Scholar 

  • Gillette, J..M., and S.M. Nielsen-Preiss, 2004, The role of annexin 2 in osteoblastic mineralization. J Cell Sci. 117(Pt 3):441–9.

    PubMed  CAS  Google Scholar 

  • Gillette, J.M., Chan, D.C., and S.M. Nielsen-Preiss, 2004, Annexin 2 expression is reduced in human osteosarcoma metastases. J Cell Biochem. 92(4):820–32.

    Article  PubMed  CAS  Google Scholar 

  • Gold, R., Oelschlager, M., Pepinsky, R.B., Sommer, C., Hartung, H.P., and K.V. Toyka KV., 1999, Increased lipocortin-1 (annexin-1) expression in the sciatic nerve of Lewis rats with experimental autoimmune neuritis. Acta Neuropathol (Berl). 98(6):583–9.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, M. Leibovitch, I., Yeffimov, I., Gavendom, S., Sela, B.A., and A. Loewenstein, 2004, Hyperhomocysteinemia in patients with diabetes mellitus with and without diabetic retinopathy. Eye 18, 460–465.

    Article  PubMed  CAS  Google Scholar 

  • Gugliucci, A. and L. Ghitescu, 2002, Is diabetic hypercoagulability an acquired annexinopathy? Glycation of annexin II as a putative mechanism for impaired fibrinolysis in diabetic patients. Med. Hypotheses 59, 247–251.

    Article  PubMed  CAS  Google Scholar 

  • Hajjar, K.A., Jacovina, A.T., and J. Chacko, 1994, An endothelial cell receptor for plasminogen/tissue plasminogen activator. I. Identity with annexin II. J Biol Chem. 269(33):21191–7.

    PubMed  CAS  Google Scholar 

  • Hajjar, K.A., 1993, Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. J. Clin. Invest s91, 2873–2879.

    Article  Google Scholar 

  • Hajjar, K.A., and S. Krishnan, 1999, Annexin II: a mediator of the plasmin/plasminogen activator system. Trends Cardiovasc. Med. 9, 128–138.

    Article  PubMed  CAS  Google Scholar 

  • Hajjar, K.A., Mauri, L., Jacovina, A.T., Zhong, F., Mirza, U.A., Padovan, J.C., and B.T. Chait, 1998, Tissue plasminogen activator binding to the annexin II tail domain. Direct modulation by homocysteine. J. Biol. Chem. 273, 9987–9993.

    Article  PubMed  CAS  Google Scholar 

  • Hannon, R., Croxtall, J.D., Getting, S.J., Roviezzo, F., Yona, S., Paul-Clark, M.J., Gavins, F.N., Perretti, M., Morris, J.F., Buckingham. J.C., and R.J. Flower, 2003, Aberrant inflammation and resistance to glucocorticoids in annexin 1–/– mouse. FASEB J. 17(2):253–5.

    PubMed  CAS  Google Scholar 

  • Hayes, M.J., Shao, D., Bailly, M., and S.E. Moss, 2006, Regulation of actin dynamics by annexin 2. EMBO J. 25, 1816–1826.

    Article  PubMed  CAS  Google Scholar 

  • Hayes, M.J., Rescher, U., Gerke, V., and S.E. Moss, 2004, Annexin-actin interactions. Traffic. 5, 571–576.

    Article  PubMed  CAS  Google Scholar 

  • Herr, C., Smyth, N., Ullrich, S., Yun, F., Sasse, P., Hescheler, J., Fleischmann, B., Lasek, K., Brixius, K., Schwinger, R. H., Fassler, R., Schroder, R., and A.A. Noegel,, 2001, Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes. Mol. Cell Biol. 21, 4119–4128.

    Article  PubMed  CAS  Google Scholar 

  • Hu, N., Flaig, M.J., Su, H., Shou, J.Z., Roth, M.J., Li, W.J., Wang, C., Goldstein, A.M., Li, G., Emmert-Buck, M.R., and P.R. Taylor, 2004, Comprehensive characterization of annexin I alterations in esophageal squamous cell carcinoma. Clin Cancer Res. 10(18 Pt 1):6013–22.

    Article  PubMed  CAS  Google Scholar 

  • Hudelist, G., Pacher-Zavisin, M., Singer, C.F., Holper, T., Kubista, E., Schreiber, M., Manavi, M., Bilban, M., and K. Czerwenka, 2004, Use of high-throughput protein array for profiling of differentially expressed proteins in normal and malignant breast tissue. Breast Cancer Res Treat. 86(3):281–91.

    Article  PubMed  CAS  Google Scholar 

  • Huitinga, I., Bauer, J., Strijbos, P.J., Rothwell, N.J., Dijkstra, C.D., and F.J. Tilders, 1998, Effect of annexin-1 on experimental autoimmune encephalomyelitis (EAE) in the rat. Clin Exp Immunol. 111(1):198–204.

    Google Scholar 

  • Hung, K.S., Howng S.L. Prognostic significance of annexin VII expression in glioblastomas multiforme in humans. J Neurosurg. 2003 Nov; 99(5):886–92.

    Google Scholar 

  • Isacke, C.M., Trowbridge,I.S. and T. Hunter, 1986, Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. Mol. Cell Biol. 6, 2745–2751.

    Google Scholar 

  • Ishii, H., Yoshida, M., Hajjar, K.A., Tanaka, A., Yasukochi, Y., Shimokado, K., and F.H. Numano, 2001, Potential role of recombinant annexin II in diabetic vascular injury. Ann. N. Y. Acad. Sci. 947, 308–311.

    Article  PubMed  CAS  Google Scholar 

  • Kang, J.S., Calvo, B.F., Maygarden, S.J,. Caskey, L.S., Mohler, J.L., and D.K. Ornstein, 2002, Dysregulation of annexin I protein expression in high-grade prostatic intraepithelial neoplasia and prostate cancer. Clin Cancer Res. 8(1):117–23.

    PubMed  CAS  Google Scholar 

  • Kang, H.J., Koh, K.H., Yang, E., You, K.T., Kim, H.J., Paik, Y.K., and H. Kim, 2006, Differentially expressed proteins in gastrointestinal stromal tumors with KIT and PDGFRA mutations. Proteomics. 6(4):1151–7.

    Article  PubMed  CAS  Google Scholar 

  • Kim, S.W., Rhee, H.J., Ko, J., Kim, Y.J., Kim, H.G., Yang, J.M., Choi, E.C., and D.S. Na, 2002, Inhibition of cytosolic phospholipase A2 by annexin I. Specific interaction model and mapping of the interaction site. J Biol Chem. 276(19):15712–9.

    Article  Google Scholar 

  • Kirschnek, S., Adams, C., and E. Gulbins, 2005, Annexin II is a novel receptor for Pseudomonas aeruginosa. Biochem Biophys Res Commun. 327(3):900–6.

    Article  PubMed  CAS  Google Scholar 

  • Kumar, V., Farell, G., Deganello, S., and J.C. Lieske, 2003, Annexin II is present on renal epithelial cells and binds calcium oxalate monohydrate crystals. J Am Soc Nephrol. 14(2):289–97.

    Article  PubMed  CAS  Google Scholar 

  • Kusumawati, A., Liautard, J.P., Sri, and J. Widada, 2001, Implication of annexin 1 in phagocytosis: effects of n-terminal domain deletions and point mutations of the phosphorylation site Ser-27. Cell Biol Int. 25(8):809–13.

    Google Scholar 

  • Lehnigk, U., Zimmermann, U., Woenckhaus, C., and J. Giebel J., 2005, Histol Histopathol Localization of annexins I, II, IV and VII in whole prostate sections from radical prostatectomy patients. 20(3):673–80.

    Google Scholar 

  • Lehnigk, U., Zimmermann, U., Woenckhaus, C., and J. Giebel, 2005, Localization of annexins I, II, IV and VII in whole prostate sections from radical prostatectomy patients. Histol Histopathol. 20(3):673–80.

    Google Scholar 

  • Lei, H., Romeo, G. and A. Kazlauskas, 2004, Heat shock protein 90alpha-dependent translocation of annexin II to the surface of endothelial cells modulates plasmin activity in the diabetic rat aorta. Circ. Res. 94, 902–909.

    Article  PubMed  CAS  Google Scholar 

  • Leighton, X., Srikantan, V., Pollard, H. B., Sukumar, S. and M. Srivastava, 2004, Significant allelic loss of ANX7region (10q21) in hormone receptor negative breast carcinomas. Cancer Lett. 210, 239–244.

    Article  PubMed  CAS  Google Scholar 

  • Lim, L.H., Solito, E., Russo-Marie, F., Flower, R.J., and M. Perretti, 1998, Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 24; 95(24):14535–9.

    Google Scholar 

  • Lim, L., H., Solito, H.E., Russo-Marie, F., Flower, R.J., and M. Perretti, 1998, Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc. Natl. Acad. Sci. USA 95:14535.

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Lira, F., Rosales-Leon, L., Martinez, V.M. and B. H. Ruiz Ordaz, 2006, The role of beta2-glycoprotein I (beta(2)GPI) in the activation of plasminogen. Biochim Biophys Acta. [Epub ahead of print]

    Google Scholar 

  • Lopez-Pedrera, C., Villalba, J.M., Siendones, E., Barbarroja N., Gomez-Diaz, C., Rodriguez-Ariza, A., Buendia, P., Torres, A., and F. Velasco, 2006, Proteomic analysis of acute myeloid leukemia: Identification of potential early biomarkers and therapeutic targets. Proteomics Suppl 1:S293–9.

    Google Scholar 

  • Lopez-Pedrera, C., Buendia, P., Barbarroja, N., Siendones, E., Velasco, F. and M.J. Cuadrado, 2006, Antiphospholipid-mediated thrombosis: interplay between anticardiolipin antibodies and vascular cells. Clin Appl Thromb Hemost. 12(1):41–5.

    Article  PubMed  CAS  Google Scholar 

  • Lopez-Pedrera, C., Buendia, P., Cuadrado, M.J., Siendones, E., Aguirre, M.A., Barbarroja, N., Montiel-Duarte, C., Torres, A., Khamashta, M., and F. Velasco, 2006, Antiphospholipid antibodies from patients with the antiphospholipid syndrome induce monocyte tissue factor expression through the simultaneous activation of NF-kappaB/Rel proteins via the p38 mitogen-activated protein kinase pathway, and of the MEK-1/ERK pathway. Arthritis Rheum. 54(1):301–11.

    Article  PubMed  CAS  Google Scholar 

  • Luo, A., Kong, J., Hu, G., Liew, C.C., Xiong, M., Wang, X., Ji, J., Wang, T., Zhi, H., Wu, M., and Z. Liu Z., 2004, Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray. Oncogene. 12; 23(6):1291–9.

    Google Scholar 

  • Ma, K., Simantov, R., Zhang, J.C., Silverstein, R., Hajjar, K.A., and K.R. McCrae, 2000, High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II. J Biol Chem. 275(20):15541–8.

    Article  PubMed  CAS  Google Scholar 

  • MacLeod, T.J., Kwon, M., Filipenko, N.R., and D.M. Waisman, 2003, Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin. J Biol Chem. 278(28):25577–84.

    Article  PubMed  CAS  Google Scholar 

  • Matsunaga, T., Inaba, T., Okuya, M., Miyajima, A., Inukai, T., Funabiki, T., Endo, M., Look, A.T. and H. Kurosawa, 2004, Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. Blood. 103(8):3185–91.

    Article  PubMed  CAS  Google Scholar 

  • Melle, C., Ernst, G., Schimmel, B., Bleul, A, Koscielny, S., Wiesner, A., Bogumil, R., Moller, U., Osterloh, D., Halbhuber, K.J., and F. Von Eggling, 2003, Biomarker Discovery and Identification in Laser Microdissected Head and Neck Squamous Cell Carcinoma with ProteinChip(R) Technology, Two-dimensional Gel Electrophoresis, Tandem Mass Spectrometry, and Immunohistochemistry. Mol Cell Proteomics. 2(7):443–52.

    PubMed  CAS  Google Scholar 

  • Menell, J.S., Cesarman, G.M., Jacovina, A.T., McLaughlin, M.A., Lev, E.A., and K. A. Hajjar, 1999, N Engl J Med. Annexin II and bleeding in acute promyelocytic leukemia. 340(13):994–1004.

    CAS  Google Scholar 

  • Mintz, M.B., Sowers, R., Brown, K.M., Hilmer, S.C., Mazza, B., Huvos, A.G., Meyers, P.A., Lafleur, B., McDonough, W.S., Henry, M.M., Ramsey, K.E., Antonescu, C.R., Chen, W., Healey, J.H., Daluski, A., Berens, M.E., Macdonald, T.J., Gorlick, R., and D. A Stephan, 2005, An expression signature classifies chemotherapy-resistant pediatric osteosarcoma. Cancer Res. 65(5):1748–54.

    Article  PubMed  CAS  Google Scholar 

  • Malhotra, R., M., Ward, H., Bright, R., Priest, M.R., Foster, M., Hurle, E. Blair, and M. Bird, 2003, Isolation and characterisation of potential respiratory syncytial virus receptor(s) on epithelial cells. Microbes Infect. 5:123–133.

    Article  PubMed  CAS  Google Scholar 

  • Mohan, R., Hammers, H.J., Bargagna-Mohan, P., Zhan, X.H., Herbstritt, C.J., Ruiz, A., Zhang, L., Hanson, A.D., Conner, B.P., Rougas, J., and V. S. Pribluda, 2004, Withaferin A is a potent inhibitor of angiogenesis. Angiogenesis. 7(2):115–22.

    Article  PubMed  CAS  Google Scholar 

  • Monastyrskaya, K., Babiychuk, E.B., Hostettler, A., Rescher, U., and A. Draeger., 2006, Annexins as intracellular calcium sensors. Cell Calcium. 2006.

    Google Scholar 

  • Morand, E.F., Hall, P., Hutchinson, P., and Y.H. Yang, 2006, Regulation of annexin I in rheumatoid synovial cells by glucocorticoids and interleukin-1. Mediators Inflamm. (2):73835.

    Google Scholar 

  • Nojima, J., Kuratsune, H., Suehisa, E., Futsukaichi, Y., Yamanishi, H., Machii, T., Iwatani, Y., and Y. Kanakura, 2001, Association between the prevalence of antibodies to beta(2)-glycoprotein I, prothrombin, protein C, protein S, and annexin V in patients with systemic lupus erythematosus and thrombotic and thrombocytopenic complications. Clin Chem. 47(6):1008–15.

    PubMed  CAS  Google Scholar 

  • Nolan, V.G., Baldwin, C., Ma, Q., Wyszynski, D.F., Amirault, Y., Farrell, J.J., Bisbee, A., Embury, S.H., Farrer, L.A., ad M.H. Steinberg, 2005, Association of single nucleotide polymorphisms in klotho with priapism in sickle cell anaemia. Br J Haematol. 128(2):266–72.

    Article  PubMed  CAS  Google Scholar 

  • Olsen, J., 1993, Some consequences of adopting a conditional deterministic causal model in epidemiology. Eur. J. Public Health 3: 204–209.

    Google Scholar 

  • Omer, S., Meredith, D., Morris, J.F., and H.C. Christian, 2006, Evidence for the role of adenosine 5 ′-triphosphate-binding cassette (ABC)-A1 in the externalization of annexin 1 from pituitary folliculostellate cells and ABCA1-transfected cell models. Endocrinology. 147(7):3219–27.

    Article  PubMed  CAS  Google Scholar 

  • Patton, K.T., Chen, H.M., Joseph, L., and X.J. Yang, 2005, Decreased annexin I expression in prostatic adenocarcinoma and in high-grade prostatic intraepithelial neoplasia. Histopathology. 47(6):597–601.

    Article  PubMed  CAS  Google Scholar 

  • Peterson, E. A., Sutherland, M, R, Nesheim, M. E., and E.L. Pryzdial. (2003) Thrombin induces endothelial cell-surface exposure of the plasminogen receptor annexin 2. J. Cell. Sci. 116: 2399–2408.

    Article  PubMed  CAS  Google Scholar 

  • Perretti, M., Croxtall, J.D., Wheller, S.K., Goulding, N.J., Hannon, R., and R.J. Flower, 1996, Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nat Med. 2(11):1259–62.

    Article  PubMed  CAS  Google Scholar 

  • Perretti, M., Christian, H., Wheller, S.K., Aiello, I., Mugridge, K.G., Morris, J.F., Flower, R.J., and N.J. Goulding, 2000, Annexin I is stored within gelatinase granules of human neutrophil and mobilized on the cell surface upon adhesion but not phagocytosis. Cell Biol Int. 24(3):163–74.

    Article  PubMed  CAS  Google Scholar 

  • Petrella, A., Festa, M., Ercolino, S.F., Zerilli, M., Stassi, G., Solito, E., and L. Parente, 2006, Annexin-1 Downregulation in Thyroid Cancer Correlates to the Degree of Tumor Differentiation. Cancer Biol Ther. 5(6):643–7.

    Article  PubMed  CAS  Google Scholar 

  • Philipps, C., Rose-John, S., Rincke, G., Furstenberger, G., and F. Marks, 1989, cDNA-cloning, sequencing and expression in glucocorticoid-stimulated quiescent Swiss 3T3 fibroblasts of mouse lipocortin I. Biochem Biophys Res Commun. 28;159(1):155–62.

    Google Scholar 

  • Pietropaolo, R., and T. Compton, 1999, Interference with annexin II has no effect on entry of human cytomegalovirus into fibroblast cells. J Gen Virol. 80 (Pt 7):1807–16.

    PubMed  CAS  Google Scholar 

  • Pietropaolo, R.L., and T. Compton, 1997, Direct interaction between human cytomegalovirus glycoprotein B and cellular annexin II. J Virol. 71(12):9803–7.

    PubMed  CAS  Google Scholar 

  • Rand, J.H., Wu, X.X., Quinn, A.S., Chen, P.P., McCrae, K.R., Bovill, E.G., and D.J.Taatjes, 2003, Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay. Am J Pathol. 163(3):1193–200.

    PubMed  CAS  Google Scholar 

  • Rand, J.H., Eerden, P.V., Wu, X.X., and C. Chazotte, 2005, Defective annexin A5 crystallization: a mechanism for pregnancy losses in the antiphospholipid syndrome. Thromb Res. 115 Suppl 1:77–81.

    PubMed  Google Scholar 

  • Rand, J.H., 2000, The annexinopathies: a new category of diseases. Biochim Biophys Acta. 1498(2,3):169–73.

    Google Scholar 

  • Rand, J.H., and X.X. Wu, 2004, Antibody-mediated interference with annexins in the antiphospholipid syndrome. Thromb Res. 114(5, g6):383–9.

    Article  PubMed  CAS  Google Scholar 

  • Rand, J.H., Wu, X.X., Lapinski, R., van Heerde, W.L., Reutelingsperger, C.P., Chen, P.P., and T.L. Ortel, 2004, Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome. Blood. 104(9):2783–90.

    Article  PubMed  CAS  Google Scholar 

  • Raynor, C.M., J.F. Wright, D.M. Waisman, and E.L. Pryzdial, 1999, Annexin II enhances cytomegalovirus binding and fusion to phospholipid membranes. Biochemistry. 38:5089–5095.

    Article  PubMed  CAS  Google Scholar 

  • Rescher, U., Ruhe, D., Ludwig, C., Zobiack, N., and V. Gerke, 2004, Annexin 2 is a phosphatidylinositol (4,5)-bisphosphate binding protein recruited to actin assembly sites at cellular membranes. J Cell Sci. 117(Pt 16):3473–80.

    Article  PubMed  CAS  Google Scholar 

  • Rodrigo, J.P., Garcia-Pedrero, J.M., Fernandez, M.P., Morgan, R.O., Suàrez, C., and A. Herrero, 2005, Annexin A1 expression in nasopharyngeal carcinoma correlates with squamous differentiation. Am J Rhinol. 19(5):483–7.

    PubMed  Google Scholar 

  • Sahin, M., Duzgun, N., Tunc, S.E. and H. Tutkak, 2006, Clinical manifestations and antiphosphatidylserine antibodies in patients with systemic lupus erythematosus: is there an association? Clin Rheumatol. (Epub ahead of print)

    Google Scholar 

  • Sebastiani, P., Ramoni, M., Nolan, V., Baldwin, C., and M. Steinberg, 2005, Genetic dissection and prognostic modeling of a complex trait: overt stroke in sickle cell anemia. Nat Genet. 37: 435–440.

    Article  PubMed  CAS  Google Scholar 

  • Shen, D., Chang, H.R., Chen, Z., He, J., Lonsberry, V., Elshimali, Y., Chia, D., Seligson, D., Goodglick, L., Nelson, S.F., and J.A. Gornbein, 2005, Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses. Biochem Biophys Res Commun. 326(1):218–27.

    Article  PubMed  CAS  Google Scholar 

  • Shen, J., Person, M.D., Zhu, J., Abbruzzese, J.L., and D. Li, 2004, Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res. 64(24):9018–26.

    Article  PubMed  CAS  Google Scholar 

  • Shi, T., Dong, F, Liou, L.S., Duan, Z.H., Novick, A.C., and J.A. DiDonato, 2004, Differential protein profiling in renal-cell carcinoma. Mol Carcinog. 40(1):47–61.

    Article  PubMed  CAS  Google Scholar 

  • Smitherman, A.B., Mohler, J.L., Maygarden, S.J., and D.K. Ornstein, 2004, Expression of annexin I, II and VII proteins in androgen stimulated and recurrent prostate cancer. J Urol. 171(2 Pt 1):916–20.

    Article  PubMed  CAS  Google Scholar 

  • Srivastava, M., Bubendorf, L., Srikantan, V., Fossom, L., Nolan, L., Glasman, M., Leighton, X., Fehrle, W., Pittaluga, S., Raffeld, M. et al. , 2001, ANX7, a candidate tumor suppressor gene for prostate cancer. Proc. Natl. Acad. Sci. USA 98, 4575–4580.

    Article  PubMed  CAS  Google Scholar 

  • Srivastava, M., Bubendorf, L., Raffeld, M., Bucher, C., Torhorst, J., Sauter, G., Olsen, C., Kallioniemi, O. P., Eidelman, O. and H.B. Pollard, 2004, Prognostic impact of ANX7-GTPase in metastatic and HER2-negative breast cancer patients. Clin. Cancer Res. 10, 2344–2350.

    Article  PubMed  CAS  Google Scholar 

  • Srivastava, M., Atwater, I., Glasman, M., Leighton, X., Goping, G., Caohuy, H., Miller, G., Pichel, J., Westphal, H., Mears, D. Rojas, E and H.B. Pollard, 1999, Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. Proc. Natl. Acad. Sci. USA 96, 13783–13788.

    Article  PubMed  CAS  Google Scholar 

  • Srivastava, M., Montagna, C., Leighton, X., Glasman, M., Naga, S., Eidelman, O., Ried, T. and H.B. Pollard, 2003, Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse.Proc. Natl. Acad. Sci. USA 100, 14287–14292.

    Article  CAS  Google Scholar 

  • Stein, T., Price, K.N., Morris, J.S., Heath, V.J., Ferrier, R.K., Bell, A.K., Pringle, M.A., Villadsen, R., Petersen, O.W., Sauter, G., Bryson, G., Mallon, E.A., and B.A Gusterson, 2005, Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. Clin Cancer Res. 11(19 Pt 1):6872–9.

    Article  PubMed  CAS  Google Scholar 

  • Tanaka, T., Akatsuka, S., Ozeki, M., Shirase, T., Hiai, H., and S. Toyokuni, 2004, Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis. Oncogene. 13; 23(22):3980–9.

    Google Scholar 

  • Taylor, H.P., and N.R. Cooper, 1990, The human cytomegalovirus receptor on fibroblasts is a 30-kilodalton membrane protein. J Virol. 64(6):2484–90.

    PubMed  CAS  Google Scholar 

  • Tuszynski, G.P., Sharma, M. R., Rothman, V. L. and M.C. Sharma, 2002, Angiostatin binds to tyrosine kinase substrate annexin II through the lysine-binding domain in endothelial cells. Microvasc. Res. 64: 448–462.

    Article  PubMed  CAS  Google Scholar 

  • van Heerde, W.L., Kenis, H., Schoormans, S., Lap, P., and C.P. Reutelingsperger, 2003, The -1C>T mutation in the annexin A5 gene does not affect plasma levels of annexin A5.

    Google Scholar 

  • van Heerde, W.L., Sakariassen, K.S., Hemker, H.C., Sixma, J.J., Reutelingsperger, C.P., and P.G. de Groot, 1994, Annexin V inhibits the procoagulant activity of matrices of TNF-stimulated endothelium under blood flow conditions. Arterioscler Thromb. 14:824–830.

    PubMed  Google Scholar 

  • Rodrigo, J.P., Garcia-Pedrero, J.M., Fernandez, M.P., Morgan, R.O., Suàrez, C., and A. Herrero, 2005, Annexin A1 expression in nasopharyngeal carcinoma correlates with squamous differentiation. Am J Rhinol. 19(5):483–7.

    PubMed  Google Scholar 

  • Reeves, S.A., Chavez-Kappel, C., Davis, R., Rosenblum, M., and M.A. Israel, 1992, Developmental regulation of annexin II (Lipocortin 2) in human brain and expression in high grade glioma. Cancer Res. 52(24):6871–6.

    PubMed  CAS  Google Scholar 

  • Roseman, B.J., Bollen, A., Hsu, J., Lamborn, K., and M.A. Israel, 1994, Annexin II marks astrocytic brain tumors of high histologic grade. Oncol Res. 1994;6(12):561–7.

    CAS  Google Scholar 

  • Strandvik, B., Bronnegard, M., Gilljam, H., and J, Carlstedt-Duke, 1988, Relation between defective regulation of arachidonic acid release and symptoms in cystic fibrosis. Scand J Gastroenterol Suppl. 143:1–4.

    PubMed  CAS  Google Scholar 

  • Selbert, S., Fischer, P., Pongratz, D., Stewart, M., and A.A Noegel, 1995, Expression and localization of annexin VII (synexin) in muscle cells. J. Cell Sci. 108 (Pt 1), 85–95.

    PubMed  CAS  Google Scholar 

  • Seidler, T., Miller, S. L., Loughrey, C. M., Kania, A., Burow, A., Kettlewell, S., Teucher, N., Wagner, S., Kogler, H., Meyers, M. B. Hasenfuss, G, and G.L. Smith, 2003, Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes. Circ. Res. 93, 132–139.

    Article  PubMed  CAS  Google Scholar 

  • Trouve, P., Legot, S., Belikova, I., Marotte, F., Benevolensky, D., Russo-Marie, F., Samuel, J.L., and D. Charlemagne, 1999, Localization and quantitation of cardiac annexins II, V, and VI in hypertensive guinea pigs Am J Physiol. 276(4 Pt 2):1159–1166.

    Google Scholar 

  • Vishwanatha, J.K., Salazar, E., and V.K. Gopalakrishnan, 2004, Absence of annexin I expression in B-cell non-Hodgkin’s lymphomas and cell lines. BMC Cancer. 8;4:8.

    Article  Google Scholar 

  • Vishwanatha, J.K., Chiang, Y., Kumble, K.D., Hollingsworth, M.A., and P.M. Pour, 1993, Enhanced expression of annexin II in human pancreatic carcinoma cells and primary pancreatic cancers. Carcinogenesis. 14(12):2575–9.

    Article  PubMed  CAS  Google Scholar 

  • Wang, J. L., Gray, R. M., Haudek, K. C. and R.J. Patterson, 2004, Nucleocytoplasmic lectins. Biochim. Biophys. Acta 1673, 75–93.

    PubMed  CAS  Google Scholar 

  • Wang, K.J., Wang, R.T., and J.Z. Zhang, 2004, Identification of tumor markers using two-dimensional electrophoresis in gastric carcinoma. World J Gastroenterol. 10(15):2179–83.

    PubMed  CAS  Google Scholar 

  • Wang, W., and T. Kirsch, 2002, Retinoic acid stimulates annexin-mediated growth plate chondrocyte mineralization. J Cell Biol. 10;157(6):1061–9.

    Google Scholar 

  • White, I.J., Bailey, L.M., Aghakhani, M.R., Moss, S.E., and C. E. Futter, 2006, EGF stimulates annexin 1-dependent inward vesiculation in a multivesicular endosome subpopulation. EMBO J. 11;25 (1):1–12.

    Google Scholar 

  • Wright, J.F., Kurosky, A., Pryzdial, E.L., and S. Wasi, 1995, Host cellular annexin II is associated with cytomegalovirus particles isolated from cultured human fibroblasts. J Virol. 69(8):4784–91.

    PubMed  CAS  Google Scholar 

  • Wu, L.N., Genge, B.R., Sauer, G.R., and R.E. Wuthier, 1996, Characterization and reconstitution of the nucleational complex responsible for mineral formation by growth plate cartilage matrix vesicles. Connect Tissue Res. 35(1–4):309–15.

    PubMed  CAS  Google Scholar 

  • Xin, W., Rhodes, D.R., Ingold, C., Chinnaiyan A.M., and M.A. Rubin, 2003, Dysregulation of the annexin family protein family is associated with prostate cancer progression. Am J Pathol. 162(1):255–61.

    PubMed  CAS  Google Scholar 

  • Yasuda, S., Bohgaki, M., Atsumi, T., and T. Koike, 2005, Pathogenesis of antiphospholipid antibodies: impairment of fibrinolysis and monocyte activation via the p38 mitogen-activated protein kinase pathway. Immunobiology. 210(10):775–80.

    Article  PubMed  CAS  Google Scholar 

  • Yokota, Y., Bargagna-Mohan, P., Ravindranath, P.P., Kim, K.B., and R. Mohan, 2006, Development of withaferin A analogs as probes of angiogenesis. Bioorg Med Chem Lett. 16(10):2603–7.

    Article  PubMed  CAS  Google Scholar 

  • Yona, S., Heinsbroek, S.E., Peiser, L., Gordon, S., Perretti, M., and R.J. Flower, 2006, Impaired phagocytic mechanism in annexin 1 null macrophages. Br J Pharmacol. 148(4):469–77.

    Article  PubMed  CAS  Google Scholar 

  • Yona, S., Heinsbroek, S.E., Peiser, L., Gordon, S., Perretti, M., and R.J. Flower, 2006, Impaired phagocytic mechanism in annexin 1 null macrophages. Br J Pharmacol. 148(4):469–77.

    Article  PubMed  CAS  Google Scholar 

  • Yu, F., Finley, R. L., Jr., Raz, A. and H.R. Kim, 2002, Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A role for synexin in galectin-3 translocation J. Biol. Chem. 277, 15819–15827.

    Article  PubMed  CAS  Google Scholar 

  • Zammiti, W., Mtiraoui, N., Kallel, C., Mercier, E., Almawi, W.Y., and T. Mahjoub, 2006, A case-control study on the association of idiopathic recurrent pregnancy loss with autoantibodies against beta 2-glycoprotein I and annexin V. Reproduction. 131(4):817–22.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, X., Zhi, H.Y., Zhang J., Wang X.Q., Zhou, C.N, Wu, M., Sun, Y.T., and Z.H. Liu, 2003, Expression of annexin II in human esophageal squamous cell carcinoma. Zhonghua Zhong Liu Za Zhi. 25(4):353–5.

    PubMed  CAS  Google Scholar 

  • Zimmermann, U., Balabanov, S., Giebel, J., Teller, S., Junker, H., Schmoll, D,. Protzel, C., Scharf, C., Kleist, B., and R. Walther R, 2004, Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. Cancer Lett. 2004. 209(1):111–8.

    Article  CAS  Google Scholar 

  • Zobiack, N., Rescher, U., Laarmann, S., Michgehl, S., Schmidt, M.A., and V. Gerke, 2002, Cell-surface attachment of pedestal-forming enteropathogenic E. coli induces a clustering of raft components and a recruitment of annexin 2. J Cell Sci. 115(Pt 1):91–8.

    PubMed  CAS  Google Scholar 

  • Zobiack, N., Rescher, U., Ludwig, C., Zeuschner, D., and V. Gerke, 2003, The annexin 2/S100A10 complex controls the distribution of transferrin receptor-containing recycling endosomes. Mol Biol Cell. 14(12):4896–908.

    Article  PubMed  CAS  Google Scholar 

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  1. Div. of Cell Biology, University College London Institute of Ophthalmology, 11–43 Bath Street, London EC1V 9EL, UK

    M.J. HAYES, R.E. LONGBOTTOM, M.A. EVANS & S.E. MOSS

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  1. University of Padova, Padova, Italy

    Ernesto Carafoli

  2. University of Padova, Padova, Italy

    Marisa Brini

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HAYES, M., LONGBOTTOM, R., EVANS, M., MOSS, S. (2007). Annexinopathies. In: Carafoli, E., Brini, M. (eds) Calcium Signalling and Disease. Subcellular Biochemistry, vol 45. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-6191-2_1

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