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P53, P63, and P73: Internecine Relations?

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25 Years of p53 Research

The discoveries of p63 and p73 as genes related to the vaunted tumor suppressor p53 launched questions that remain largely unanswered, and fuel controversy and debate. Do these homologs behave like p53? Do they also act in tumor suppression? What were their origins – spin-offs of an ancestral p53 gene, or, in fact, predecessors of this famed ‘guardian of the genome’? In vivo studies clearly reveal distinct physiological roles for p53, p63, and p73. But do these belie cooperative or antagonistic interactions within the p53 gene family?

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Authors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, Boston, MA, USA

    Frank McKeon

  2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA

    Annie Yang

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  1. Frank McKeon
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Editors and Affiliations

  1. International Agency for Research on Cancer, World Health Organization, Lyon, France

    Pierre Hainaut

  2. Cancer Center Karolinska, Karolinska Institute, Stockholm, Sweden

    Klas G. Wiman

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McKeon, F., Yang, A. (2007). P53, P63, and P73: Internecine Relations?. In: Hainaut, P., Wiman, K.G. (eds) 25 Years of p53 Research. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-2922-6_9

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