Abstract
Hanin and Usdin (1977) have succinctly expressed the criteria which must be fulfilled by an animal model of a neurological or psychiatric disease. ‘A good animal model of any particular disease state is one which will simulate and reproduce most accurately the human syndrome which it is designed to represent. Ideally, it should mirror behaviorally the symptoms of the disorder and should respond to pharmacologic and appropriate therapeutic agents in a manner identical to that observed in the original human state’. So far, no animal model of the affective disorders entirely satisfies these criteria. Nevertheless, the changes in the behavior and central neurotransmitter function following the bilateral ablation of the olfactory lobes of the rat represents, in our opinion, an animal model that comes close to satisfying such a condition. The aim of this review is to assess critically the behavioral changes which occur in the rat following bulbectomy and to show how drugs known to attenuate effectively the symptoms of depression in man can counteract the behavioral deficits which result from the lesion.
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Jancsár, S., Leonard, B.E. (1983). The olfactory bulbectomized rat as a model of depression. In: Usdin, E., Goldstein, M., Friedhoff, A., Georgotas, A. (eds) Frontiers in Neuropsychiatric Research. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06689-6_25
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