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Aliphatic amines as MAO substrates in the rat: the effect of selective inhibitors on the deamination of n-pentylamine

  • Chapter
Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects

Abstract

Monoamine oxidase (MAO, EC 1.4.3.4.) is an enzyme widely distributed in mammalian tissues and especially in the brain. Two major forms, MAO A and MAO B seem to exist on the basis of substrate specificity and existence of reversible and irreversible inhibitors. MAO A preferentially deaminates biogenic amines such as 5-hydroxy-tryptamine (5-HT), adrenaline and noradrenaline and is selectively inhibited by clorgyline, whereas MAO B oxidises the microamine phenylethylamine (PEA) and is inhibited by deprenyl (Neff et al., 1976; Fowler et al., 1978; Gerardy, 1980; Houslay et al., 1976).

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References

  • Backle, Y.S. and Youdim, M.B.H. (1975). J. Physiol. (London), 248, 1, 111–115.

    Google Scholar 

  • Barger, G. and Dale, H.H. (1910)., J. Physiol., 41, 19–59.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Baum, T. and Bennett, D.R. (1963). Arch. int. Pharmacodyn., 146, No 1–2, 280–284.

    CAS  PubMed  Google Scholar 

  • Boismare, F., Derrey, D., Audisio, M. and Brocherion, J. (1974). Therapie, 29, 435–446.

    Google Scholar 

  • Boulton, A.A. (1978). Life Sci., 23, 659–672.

    Article  CAS  PubMed  Google Scholar 

  • Boulton, A.A. (1979). in Physiological and Pharmacological Biochemistry, Vol. 26 (ed. K.F. Tipton), University Park Press, Baltimore., pp 179–206.

    Google Scholar 

  • Braestrup, C., Andersen, H. and Randrup, A. (1975). Eur. J. Pharmacol., 34, 181–187.

    Article  CAS  PubMed  Google Scholar 

  • Burkard, W.P. and Kettler, R. (1977). Biochem. Pharmacol., 26, 1303–1306.

    Article  CAS  Google Scholar 

  • Burtin, C., Lebel, B. and Soubrane, C. (1977). Ag. Actions, 7, No 1, 107.

    Article  CAS  Google Scholar 

  • Chanoine, F., Strolin Benedetti, M., Ancher, J.F. and Dostert, P. submitted Arzneim.-Forsch.

    Google Scholar 

  • Cohen, G., MacNamee, D. and Dembiec, D. (1975). Biochem. Pharmacol. 24, 3.13–316.

    Article  Google Scholar 

  • Curda, D., Hrdlicka, J. and Procingerova, A. (1972). Sb. Vys. Sk. Chem.-Technol. Praze, Potraviny, E 34, 65–84.

    Google Scholar 

  • Dembiec, D., MacNamee, D. and Cohen, G. (1976). J. Pharmac. Exp. Therap., 197, 332–339.

    CAS  Google Scholar 

  • Dial, J. and Clarke, D.E. (1977). Res. Commun. Chem. Pathol. Pharmacol., 17, Nol, 145–156.

    CAS  PubMed  Google Scholar 

  • Diehl, E., Najm, S., Wolff, R.E. and Ehrhardt, J.D. (1976). J. Pharmacol., 7, 563–575.

    CAS  Google Scholar 

  • Donnelly, C.H. and Murphy, D. (1977). Biochem. Pharmacol., 26, 853–858.

    Article  CAS  PubMed  Google Scholar 

  • Drawert, F. (1965). Vitis, 5, 2, 127–130.

    CAS  Google Scholar 

  • Durden, D.A., Philips, S.R. and Boulton, A.A. (1976). Biochem. Pharmacol., 25, 858–859.

    Article  CAS  PubMed  Google Scholar 

  • Edwards, D.J. and Venetti, M.C. (1977). Neurosci. Abstr., 3, 313.

    Google Scholar 

  • Edwards, D.J. (1978). Life Sci., 23, 1201–1208.

    Article  CAS  PubMed  Google Scholar 

  • Elsworth, J.D., Glover, V. and Sandler, M. (1980). Psychopharmacology., 69, No3, 287–290.

    Article  CAS  PubMed  Google Scholar 

  • Fowler, C.J., Callingham, B.A., Mantle, T.J. and Tipton, K.F. (1978). Biochem. Pharmacol., 27, 97–101.

    Article  CAS  Google Scholar 

  • Fowler, C.J., Ekstedt, B., Egashira, T., Kinemuchi, H. and Oreland, L. (1979). Biochem. Pharmacol., 28, 3063–3068.

    Article  CAS  PubMed  Google Scholar 

  • Fowler, J.S., Gallagher, B.M., MacGregor, R.R. and Wolf, A.P. (1976). J. Pharmacol. Exp. Therap., 198, 1, 133–145.

    CAS  Google Scholar 

  • Gallagher., B.M., Fowler, J.S., MacGregor, R.R. and Wolf, A.P. (1977). Biochem. Pharmacol., 26, 1917–1922.

    Google Scholar 

  • Gérardy, J. (1980). Pharm. Belg., 35, 2, 133–142.

    Google Scholar 

  • Golovnya, R.V., Mironov, G.A. and Zhuraveleva, I.L. (1967). Zh. Anal. Khim., 22(4), 612–617.

    CAS  Google Scholar 

  • Hough, L.B. and Domino, E.F. (1979). J. Pharmacol. Exp. Therap. 208, 3, 422–428.

    CAS  Google Scholar 

  • Houslay, M.D., Garrett, N.J. and Tipton, K.F. (1974). Biochem. Pharmacol., 23, 1937–1944.

    Article  CAS  PubMed  Google Scholar 

  • Houslay, M.D. and Tipton, K.F. (1976). Life Sci., 19, 467–478.

    Article  CAS  PubMed  Google Scholar 

  • Hrdlicka. J. and Janicek, G. (1964). Nature, 204, (4964), 1201.

    Google Scholar 

  • Innes, I.R. and Nickerson, M. (1975). in The Pharmacological Basis of Therapeutics, 5th ed. (eds. L.S. Goodman and A. Gilman) Macmillan Publishing Co., N.Y., pp L77–513.

    Google Scholar 

  • Irvine, W.J. and Saxby, M.J. (1969). Phytochemistry, 8 (2), 473–476.

    Article  CAS  Google Scholar 

  • Jalfre, M., Bucher, B., Coston, A., Mocquet, G. and Porsolt, R.D. (1980). Abstracts of the 12th CINP Congress, Göteborg, No 316, Pergamon Press.

    Google Scholar 

  • Johnston., J.P. (1968). Biochem. Pharmacol., 17, 1285–1297.

    Google Scholar 

  • Kan, J.P. and Strolin Benedetti, M. (1980). Life Sci., 26, 2165–2171.

    Article  CAS  PubMed  Google Scholar 

  • Kan, J.P. and Strolin Benedetti, M. (1981). J. Neurochem., in press.

    Google Scholar 

  • Kinemuchi, H., Wakui, Y., Toyoshima, Y., Hayashi, N. and Kamijo, K. (1979). in Monoamine oxidase: structure, function and alte-red functions, (eds. T.P. Singer, R.W. von Korff and D.L. Murphy) Academic Press. pp 205–212.

    Google Scholar 

  • Klemm, H.P. and Baumgarten, H.G. (1978). Ann. N.Y. Acad. Sci., 305, 36–56.

    Article  CAS  PubMed  Google Scholar 

  • Knight, R. I. and Smith, I.R. (1978). Br. J. Pharmacol., 64, 404P.

    Google Scholar 

  • Kung, H.C. and Wilson, A.G.E. (1979). Life Sci., 24, 425–432.

    Article  CAS  PubMed  Google Scholar 

  • Lebsack, M.E., Petersen, D.R. and Collins, A.C. (1977). Biochem. Pharmacol., 26, 1151–1154.

    Article  CAS  PubMed  Google Scholar 

  • Lehninger, A.L. (1975). in Biochimica, (ed. Zanchelli), Chapter 19

    Google Scholar 

  • Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) J. Biol. Chem., 193, 265–275.

    CAS  PubMed  Google Scholar 

  • Lyles, G.A. (1978). Life Sci., 23, 223–230.

    Article  CAS  PubMed  Google Scholar 

  • Mantle, T.J., Tipton, K.F. and Garrett, N.J. (1976). Biochem. Pharmacol., 25, 2073–2077.

    Article  CAS  PubMed  Google Scholar 

  • Mongar., J.L. and Schild, H.O. (1953). Br. J. Pharmacol., 8, 103109.

    Google Scholar 

  • Murphy, D.L., Lipper, S., Slater, S. and Shiling, D. (1979). Psychopharmacology, 62, 129–132.

    Article  CAS  PubMed  Google Scholar 

  • Nakanishi, S., Yamazaki, H. Nishiguchi, K. and Saladin R. (1980). Arch. Toxicol., 46, 241–248.

    Article  CAS  PubMed  Google Scholar 

  • Neff, N.H. and Yang, H.-Y.T. (1974). Life Sci., 14, 2061–2074.

    Article  CAS  PubMed  Google Scholar 

  • Neff, N.H. and Fuentes, J.A. (1976). in Monoamine oxidase and its inhibition, Ciba Foundation Symposium 39, Elsevier, Excerpta Medica, pp 163–179.

    Google Scholar 

  • Ney, K.H. and Wirotama, I.P.G. (1971a). Z. Lebensm.-Unters.-Forsch. 146. (6), 337–343.

    Article  CAS  Google Scholar 

  • Ney, K.H. and Wirotama, I.P.G. (1971b). Z. Lebensm.-Unters.-Forsch. 146 (6), 343–344.

    Article  CAS  Google Scholar 

  • Nonaka, J., Le Thi Minh, D. and Koizumi, C. (1975). J. Tokyo Univ. Fish., 62 (1). 1–10.

    CAS  Google Scholar 

  • Pailer, M., Huebsch, J. and Kuhn, H. (1966). Monatsh. Chem., 97, 5, 1448–1451.

    Article  CAS  Google Scholar 

  • Peers, E.M., Lyles, G.A. and Callingham, B.A. (1980). Biochem. Pharmacol., 29, 1097–1102.

    Article  CAS  PubMed  Google Scholar 

  • Philips, S.R. and Boulton., A.A. (1979). J. Neurochem., 33, 159–167.

    Article  CAS  PubMed  Google Scholar 

  • Pirisino, R., Ciottoli, C.B., Buffoni, F., Anselmi, B. and Curradi, C. (1979). Br. J. Clin. Pharmacol., 7. No6. 595–598.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Polonovski, J. (1967). in Traité de Biochimie Génerale, III, (ed. Masson et Cie, Paris), pp 254–271.

    Google Scholar 

  • Pourrias, B., Sergant, M. and Raynaud, G. (1969). Therapie, 24, 451–466.

    CAS  PubMed  Google Scholar 

  • Prozialeck, W.C. and Vogel, W.H. (1978). Life Sci., 22, No 7, 561–569.

    Article  CAS  Google Scholar 

  • Reynolds, G.P., Elsworth, J.D., Blau, K., Sandler, M., Lees, A.J. and Stern, G.M. (1978). Br. J. Clin. Pharmacol., 6, No 6, 542–544.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Riceberg, L.J. and Vunakis, H.van (1978). Abstr. Papers, Am. Chem. Soc. 176 Meet. BIOL. 133.

    Google Scholar 

  • Sanders, B., Collins, A.C., Petersen, D.R. and Fish, B.S. (1977). Pharmacology Biochemistry and Behavior, 6, 319–324.

    Article  CAS  Google Scholar 

  • Shirota, F.N., DeMaster, E.G., Elberling, J.A. and Nagasawa, H.T. (1980). J. Med. Chem., 23, 669–673.

    Article  CAS  PubMed  Google Scholar 

  • Sourkes, T.L. (1972). Pharmacological Keviews, 24, 2, 349–359.

    CAS  Google Scholar 

  • Sourkes, T.L. and Missala, K. (1976) in Monoamine oxidase and its inhibition, Ciba Foundation Symposium 39, Elsevier, Excerpta Medica, pp 83–103.

    Google Scholar 

  • Sourkes,. T.L. and Missala, K. (1977a). Can. J. Biochem., 55, 1, 56–59.

    Google Scholar 

  • Sourkes, T.L., Missala, K., Bastomsky, C.H. and Fang, T.Y.(1977b) Can. J. Biochem., 55, 8, 789–795.

    Article  CAS  PubMed  Google Scholar 

  • Strolin Benedetti, M., an, J.P. and Keane, P.E. (1979) in Monoamine oxidase: Structure, function and altered functions, (eds. T.P. Singer, R.W. von Korff and D.L. Murphy) Academic Press, pp 335–340.

    Google Scholar 

  • Strolin Benedetti, M., Ancher, J.F. and Sontag, N. (1980). Experientia, 36, 818–820.

    Article  CAS  Google Scholar 

  • Suzuki, O., Katsumata, Y. and Oya, M. (1979a). Biochem. Pharmacol. 28, 2327–2332.

    Article  CAS  PubMed  Google Scholar 

  • Suzuki., O., Hattori, H., Katsumata, Y. and Oya, M. (1979b). Life Sci., 25, 1231–1236.

    Google Scholar 

  • Suzuki, O., Oya, M. and Katsumata, Y. (1979c). Biochem. Pharmacol., 28, 2682–2684.

    Article  CAS  PubMed  Google Scholar 

  • Suzuki, O., Matsumoto, T., Oya, M. and Katsumata, Y. (1979d). Experientia, 35, 1283–1284.

    Article  CAS  PubMed  Google Scholar 

  • Suzuki, O., Katsumata, Y. and Oya, M. (1979e). Life Sci., 24, 2227–2230.

    Article  CAS  PubMed  Google Scholar 

  • Suzuki, O., Katsumata, Y. and Oya, M. (1979f) in Monoamine oxidase: structure, function and altered functions, (eds. T.P. Singer., R.W. von Korff and D.L. Murphy) Academic Press, pp 197–204.

    Google Scholar 

  • Suzuki, O., Oya, M. and Katsumata, Y. (1980). Biochem. Pharmacol. 29, 2663–2667.

    Article  CAS  PubMed  Google Scholar 

  • Symes, A.L., Missala, K. and Sourkes, T.L. (1971). Science, 174, 153–155.

    Article  CAS  PubMed  Google Scholar 

  • Swanson, E.E. and Chen, K.K. (1946). J. Pharmacol. Exp. Therap. 88, 10–13.

    CAS  Google Scholar 

  • Tainter, M.L. (1933). Arch. int. Pharmacodyn., 46, 192–232.

    CAS  Google Scholar 

  • Tierney, D.F. (1974). Annu. Rev. Physiol., 36, 209–231.

    Article  Google Scholar 

  • Tuomisto, J., Walaszek, L.J. and Smissman, E.E. (1974). J. Pharm. Sci., 63, (1), 15–18.

    Article  CAS  PubMed  Google Scholar 

  • Waldmeier, P.C., Feldtrauer, J.J. and Maitre, L. (1977a). Arch. Pharmac., 297, suppl. 2, R57.

    Article  Google Scholar 

  • Waldmeier, P.C., Feldtrauer, J.J. and Maître, L. (1977b). J. Neurochem., 29. 785–790.

    Article  CAS  PubMed  Google Scholar 

  • Wechsler, A.S., Epstein, S.E. and Glick, G. (1969). J. Pharmacol. Exp. Therap., 170, 62–71.

    CAS  Google Scholar 

  • Yu, P.H. and Boulton, A.A. (1980). J. Neurochem., 35. 255–257.

    Article  CAS  PubMed  Google Scholar 

  • Zilletti, L., Franchi Michell, S. and Rosselli, P. (1978). Ag. Actions, 8, No 5, 462–469.

    Article  CAS  Google Scholar 

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Authors and Affiliations

    Authors
    1. Margherita Strolin Benedetti
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    2. Nicole Sontag
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    3. Thierry Boucher
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    4. Jean-Paul Kan
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    Editors and Affiliations

    1. National Institute of Mental Health, USA

      Earl Usdin

    2. University of Colorado, USA

      Norman Weiner

    3. Technion Faculty of Medicine, USA

      Moussa B. H. Youdim

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    Benedetti, M.S., Sontag, N., Boucher, T., Kan, JP. (1981). Aliphatic amines as MAO substrates in the rat: the effect of selective inhibitors on the deamination of n-pentylamine. In: Usdin, E., Weiner, N., Youdim, M.B.H. (eds) Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-06276-8_58

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