Abstract
Following the discovery of Substance P (SP) in extracts of equine gut and brain by von Euler and Gaddum (1931), a considerable number of studies have been carried out on the distribution and pharmacology of this substance in various mammalian tissues. The earlier work has been well reviewed by Lembeck and Zetler (1962). SP was found to be present in relatively high concentrations in various nervous tissues, particularly in sensory nerve pathways. The idea that SP might correspond to the ‘Sensory Transmitter Factor’ studied by Hellauer and Umrath (1947, 1948) in extracts of dorsal root was also suggested some 25 years ago by Lembeck (1953), and has been championed particularly vigorously since then by this author (Lembeck and Zetler, 1962 and Lembeck this volume, chapter 8). Latterly the work of Otsuka and his colleagues has provided strong support to the view that SP functions as a sensory transmitter in the spinal cord (Otsuka and Konishi, 1975). Earlier studies on SP were hampered by the limited availability of purified material, and by the lack of a simple, specific and sensitive assay method. This situation has changed dramatically since the elucidation by Leeman and her colleagues and by Studer et al. (1973) of the chemical structure of SP as an undecapeptide, (Chang and Leeman, 1970; Chang et al., 1971; Leeman and Mroz, 1974) and by the chemical synthesis of the peptide (Tregear et al., 1971) and the development of a radioimmunoassay technique (Powell et al., 1973). More recently, an immunohistochemical technique for visualising the cellular localisation of SP has been developed and applied by Nilsson et al. (1974).
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References
Angelucci, L. (1956). Br.J.Pharmac., 11, 161–170
Atweh, S. F. and Kuhar, M. J. (1977). Brain Res., 124, 53–67
Belcher, G. and Ryall, R. W. (1977). J.Physiol,, Lond., (in press)
Benuck, M. and Marks, N. (1975). Biochem. biophys. Res. Commun., 65, 153–60
Brownstein, M. J., Mroz, E. A., Kizer, J. S., Palkovits, M. and Leeman, S. E. (1976). Brain Res., 116, 299–305
Calvillo, O., Henry, J. L. and Neuman, R. S. (1974). Can.J.Physiol.Pharmac., 52, 1207–11
Catlin, D. H., Schaeffer, J. C. and Loewen, M. B. (1977). Life Sci., 20, 123–132
Chang, M. M. and Leeman, S. E. (1970). J. biol. Chem., 245, 4784–89
Chang, M. M., Leeman, S. E. and Niall, H. D. (1971). Nature new Biot, 232, 86–87
Claybrook, D. L. and Pfiffner, J. J. (1968). Biochem.Pharmac., 17, 281–193
Coyle, J. T. and Schwarcz, R. (1976). Nature, 263, 244–46
Cuello, A. C., Polak, J. and Pearse, A. (1976). Lancet, ii, 1054–56
Cuello, A. C. and Kanazawa, I. (1977). J. comp. Neurol., (in press)
Cuello, A. C., Jessell, T., Kanazawa, I. and Iversen, L. L. (1977a). J. Neurochem., (in press)
Cuello, A. C., Emson, P. C., Jessell, T., and Paxinos, G. (1977b). Brain Res., (in press)
Cuello, A. C., del Fiacco, M. and Paxinos, G. (1977c). Brain Res., (in press)
De Robertis, E. (1964). Histophysiology of Synapses and Neurosecretion. Pergamon Press, Oxford
Desbuquois, B. and Cuatrecasas, P. (1972). Nature new Biot, 236, 202–04
Davies, J. and Dray, A. (1976). Brain Res., 107, 623–27
Davies, J. and Dray A. (1977). Nature, 268, 351–52
Dray, A. and Straughan, D. W. (1976). J.Pharm.Pharmac., 28, suppl., 333–405
Duffy, M. J. and Powell, D. (1975). Biochim. biophys. Acta., 385, 275–80
Duffy, M. J., Mulhall, D. and Powell, D. (1975a). J. Neurochem., 25, 305–07
Duffy, M. J., Wong, J. and Powell, D. (1975b). Neuropharmacology, 14, 615–18
Duggan, A. W., Hall, J. G. and Headley, P. M. (1976). Nature, 264, 456–58
Emson, P. C., Kanazawa, I., Cuello, A. C. and Jessell, T. M. (1976). Biochem.Soc. Trans. 5, 187–89
Emson, P. C., Jessell, T., Paxinos, G. and Cuello, A. C. (1977). Brain Res., (submitted)
Euler, U. S. von and Gaddum, J. H. (1931). J.Physiol., Lond, 72, 74–87
Euler, U. S. von and Lishajko, F. (1961). Proc.Scl.Soc.Bosnia Herzegovina, 1, 109–12
Fonnum, F., Grofova, I., Rinvik, E., Storm-Mathisen, J. and Walberg, F. (1974). Brain Res., 71, 77–92
Gaddum, J. H. (1961). Pro c.Sci.Soc.Bosnia Herzegovina, 1, 7–13
Gale, J. S., Bird, E. D., Spokes, E., Iversen, L. L. and Jessell, T. M. (1977). J. Neurochem., (in press)
Hattori, T., McGeer, P. L., Fibiger, H. C. and McGeer, E. G. (1973). Brain Res., 54, 103–14
Hellauer, H. F. and Umrath, K. (1947). J.Physiol., Lond, 106, 20 P
Hellauer, H. F. and Umrath, K. (1948). Pflügers Arch. ges. Physiol., 249, 619–30
Henry, J. L. (1976). Brain Res., 114, 439–51
Hökfelt, T., Kellerth, J. O., Nilsson, G. and Pernow, B. (1975a). Science, 190, 889–90
Hökfelt, T., Kellerth, J. O., Nilsson, G. and Pernow, B. (1975b). Brain Res., 100, 235–52
Hökfelt, T., Elde, R., Johansson, O., Luft, R., Nilsson, G. and Arimura, A. (1975c). Neuroscience, 1, 131–36
Hong, J. S., Costa, E. and Yang, H.-Y. T. (1977a). Brain Res., 118, 523–25
Hong, J. S., Yang, H.-Y. T., Racagni, G. and Costa, E. (1977b). Brain Res., 122, 541–44
Inouye, A., and Kataoka, K. (1962). Nature, 193, 585
Jessell, T. (1977a). Br.J.Pharmac., 59, 486 P
Jessell, T. (1977b). J.Physiol., Lond, 270, 56–57 P
Jessell, T. (1977c). Brain Res., (in press)
Jessell, T. and Iversen, L. L. (1977). Nature, 268, 549–51
Jessell, T., Iversen, L. L. and Kanazawa, I. (1976). Nature, 264, 81–83
Jessell, T., Emson, P. C., Paxinos, G. and Cuello, A. C. (1977). Brain Res., (submitted)
Jhamandas, K., Phillis, J. W. and Pinsky, C. (1971). Br.J.Pharmac., 43, 53–66
Kanazawa, I. and Jessell, T. (1976). Brain Res., 117, 362–67
Kanazawa, I., Emson, P. C. and Cuello, A. C. (1977a). Brain Res., 119, 447–53
Kanazawa, I., Bird, E., O’Connell, R. and Powell, D. (1977b). Brain Res., 120, 387–92
Kitahata, L. M., Kosaka, Y., Taub, A., Bonikos, K. and Hoffert, M. (1974). Anaesthesiology, 41, 39–48
Konishi, S. and Otsuka, M. (1974). Brain Res., 65, 397–410
Krnjevib, K. and Morris, M. E. (1974). Can.J.Physiol.Pharmac., 52, 736–44
Lamotte, C., Pert, C. B. and Snyder, S. H. (1976). Brain Res, 112, 407–12
Le Bars, D., Guilbaud, G., Jurna, I. and Besson, J. M. (1976). Brain Res, 115, 518–24
Leeman, S. E. and Mroz, E. A. (1974). Life Sci., 15, 2033–44
Lembeck, F. (1953). Naunyn-Schmiedebergs Arch. exp. Path. Pharmac., 219, 197–213
Lembeck, F. and Holasek, A. (1960). Naunyn-Schmiedebergs Arch. exp. Path. Pharmac., 238, 542–45
Lembeck, F. and Zetler, G. (1962), Int.Rev.Neurobiol., 4, 159–215
Loh, H. H., Brase, D. A., Sampath-Khanna, S., Mar, J. B., Leong-Way, E. and Li, C. H. (1976). Nature, 264, 567–68
McKelvy, J. F., LeBlanc, P., Laudes, C., Perrie, S., Grimm-Jorgensen, Y. and Kordon, C. (1976). Biochem. biophya Res.Commun., 73, 507–15
Miletić, V., Kovacs, M. and Randi6, M. (1977). Fedn Proc., 36, 1014
Miller, R. J., Chang, K.-J, and Cuatrecasas, P. (1977). Biochem. biophys. Res. Commun., 74, 1311–17
Mroz, E. A., Brownstein, M. J. and Leeman, S. E. (1976). Brain Res., 113, 597–99
Nilsson, G., HSkfelt, T. and Pemow, B. (1974). Med. Biol., 52, 424–27
Otsuka, M. and Konishi, S. (1975). Cold Spring Harb. Symp. quant. Biol., 40, 135–43
Otsuka, M. and Konishi, S. (1976). Nature, 264, 83–84
Phillis, J. W. and Limacher, J. J. (1974). Brain Res., 69, 158–63
Pickel, V. M., Reis, D. J. and Leeman, S. E. (1977). Brain Res., 122, 534–40
Powell, D., Leeman, S. E., Tregear, G. W., Niall, H. D. and Potts, J. T. Jr (1973). Nature new Biol., 241, 252–54
Przić, R. (1961). Proc.Sci.Soc.Bosnia.Herzegovina, 1, 71
Quik, M. and Jessell, T. (1978) J. Neurochem., (in press)
Richter, J. A. and Goldstein, A. (1970). Proc. natn. Acad. Sci. U.S.A., 66, 944–51
Ryall, R. W. (1962). Nature, 196, 680–81
Ryall, R. W. (1964). J.Neurochem., 11, 131–45
Saito, K., Konishi, S. and Otsuka, M. (1975). Brain Res, 97, 177–80
Schenker, C., Mroz, E. A. and Leeman, S. E. (1976). Nature, 264, 790–92
Shaw, J. E. and Ramwell, P. W. (1968). Am.J.Physiol., 215, 262–67
Snyder, S. H. and Simantov, R. (1977). J.Neurochem., 28, 13–20
Steinacker, A. and Highstein, S. M. (1976). Brain Res., 114, 128–33
Stewart, J. M., Getto, C. J., Neldner, K., Reeve, E. B., Krivoy, W. A. and Zimmermann, E. (1976). Nature Lond, 262, 784–85
Studer, R. O., Trzeciak, A. and Lergier, W. (1973). Helv. chim. Acta., 56, 860–66
Takahashi, T. and Otsuka, M. (1975). Brain Res, 87, 1–11
Taube, H. D., Borowski, E., Endo, T. and Starke, K. (1976). Eur.J.Pharmac., 38, 377–80
Tregear, G. W., Niall, H. D., Potts, J. T. Jr, Leeman, S. E. and Chang, M. M. (1971). Nature new Biol., 232, 86–89
Whittaker, V. P. (1965). Progr. Biophys. molec. Biol., 15, 39–96
Yaksh, T. L. and Rudy, T. A. (1976). Science, 192, 1357–58
Zetler, G. (1956). Naunyn-Schmiedebergs Arch. exp. Path. Pharmac., 228, 513–38
Zetler, G. and Schlosser, L. (1955). Naunyn-Schmiedebergs Arch. exp. Path. Pharmac., 224, 159–75
Zigmond, R. and Ben-Ari, Y. (1976). J. Neurochem., 26, 1285–89
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Cuello, A.C. et al. (1978). Distribution and release of Substance P in the central nervous system. In: Hughes, J. (eds) Centrally Acting Peptides. Biological Council. Palgrave Macmillan, London. https://doi.org/10.1007/978-1-349-03668-4_9
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