The Relation between Classical and Cooperative Models for Drug Action

Colquhoun, D.

doi:10.1007/978-1-349-00910-7_11

D. Colquhoun²^nAff3

Part of the book series: Biological Council

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Abstract

It is not my purpose to advocate any particular model for drug action as being the truth. And, a fortiori the particular values of parameters used here in numerical examples are chosen for illustration only, though they are chosen to be not grossly incompatible with experimental results (see p. 163). My intention is merely to discuss the extent to which some new observations are compatible with the substantial body of quantitative evidence that is consistent with the classical ideas about drug action. These new observations suggest that some form of cooperative step is involved in the response to certain agonists, whereas no cooperativity was postulated in the classical ideas about drug action.

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D. Colquhoun
Present address: Department of Physiology and Biochemistry, University of Southampton, Southampton, SO9 3TU, England

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Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA
D. Colquhoun

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D. Colquhoun
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Department of Physiology and Biochemistry, University of Southampton, UK
H. P. Rang

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Colquhoun, D. (1973). The Relation between Classical and Cooperative Models for Drug Action. In: Rang, H.P. (eds) Drug Receptors. Biological Council. Palgrave, London. https://doi.org/10.1007/978-1-349-00910-7_11

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DOI: https://doi.org/10.1007/978-1-349-00910-7_11
Publisher Name: Palgrave, London
Print ISBN: 978-1-349-00912-1
Online ISBN: 978-1-349-00910-7
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