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A Survey of Transcription Factors in Cell Fate Control

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Transcription Factor Regulatory Networks

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2594))

Abstract

Transcription factors (TFs) play a cardinal role in the development and maintenance of human physiology by acting as mediators of gene expression and cell state control. Recent advancements have broadened our knowledge on the potency of TFs in governing cell physiology and have deepened our understanding of the mechanisms through which they exert this control. The ability of TFs to program cell fates has gathered significant interest in recent decades, and high-throughput technologies now allow for the systematic discovery of forward programming factors to convert pluripotent stem cells into numerous differentiated cell types. The next generation of these technologies has the potential to improve our understanding and control of cell fates and states and provide advanced therapeutic modalities to address many medical conditions.

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Author information

Author notes

  1. Emal Lesha, Haydy George and Mark M. Zaki contributed equally with all other contributors.

Authors and Affiliations

  1. GC Therapeutics Inc., Cambridge, MA, USA

    Emal Lesha, Haydy George, Mark M. Zaki, Cory J. Smith, Parastoo Khoshakhlagh & Alex H. M. Ng

  2. Department of Neurosurgery, University of Tennessee Health Science Center, Memphis, TN, USA

    Emal Lesha

  3. School of Medicine, St. George’s University, West Indies, Grenada

    Haydy George

  4. Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA

    Mark M. Zaki

Authors
  1. Emal Lesha
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  2. Haydy George
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  3. Mark M. Zaki
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  4. Cory J. Smith
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  5. Parastoo Khoshakhlagh
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  6. Alex H. M. Ng
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Corresponding authors

Correspondence to Parastoo Khoshakhlagh or Alex H. M. Ng .

Editor information

Editors and Affiliations

  1. Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA

    Qi Song

  2. Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Zhipeng Tao

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© 2023 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature

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Lesha, E., George, H., Zaki, M.M., Smith, C.J., Khoshakhlagh, P., Ng, A.H.M. (2023). A Survey of Transcription Factors in Cell Fate Control. In: Song, Q., Tao, Z. (eds) Transcription Factor Regulatory Networks. Methods in Molecular Biology, vol 2594. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2815-7_10

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  • DOI: https://doi.org/10.1007/978-1-0716-2815-7_10

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-2814-0

  • Online ISBN: 978-1-0716-2815-7

  • eBook Packages: Springer Protocols

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