Abstract
There is still an urgent need to develop effective treatments to help minimize the cases of severe COVID-19. A number of tools have now been developed and applied to address these issues, such as the use of non-contrast chest computed tomography (CT) for evaluation and grading of the associated lung damage. Here we used a deep learning approach for predicting the outcome of 1078 patients admitted into the Baqiyatallah Hospital in Tehran, Iran, suffering from COVID-19 infections in the first wave of the pandemic. These were classified into two groups of non-severe and severe cases according to features on their CT scans with accuracies of approximately 0.90. We suggest that incorporation of molecular and/or clinical features, such as multiplex immunoassay or laboratory findings, will increase accuracy and sensitivity of the model for COVID-19 -related predictions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
https://www.worldometers.info/coronavirus/. Accessed 23 Oct 2021
Johns Hopkin’s Coronavirus Resource Center. https://coronavirus.jhu.edu/map.html. Accessed 23 Oct 2021
Our world in data. Coronavirus (COVID-19) Vaccinations. https://ourworldindata.org/covid-vaccinations. Accessed 23 Oct 2021
Song Q, Sun X, Dai Z et al (2021) Point-of-care testing detection methods for COVID-19. Lab Chip 21(9):1634–1660
Zhang L, Guo H (2021) Biomarkers of COVID-19 and technologies to combat SARS-CoV-2. Adv Biomark Sci Technol 2:1–23
Haridy S, Maged A, Baker AW et al (2021) Monitoring scheme for early detection of coronavirus and other respiratory virus outbreaks. Comput Ind Eng 156:107235. https://doi.org/10.1016/j.cie.2021.107235
Chen H, Guo J, Wang C et al (2020) Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet 395(10226):809–815
Ghayda RA, Lee KH, Kim JS et al (2021) Chest CT abnormalities in COVID-19: a systematic review. Int J Med Sci 18(15):3395–3402
Au WY, Cheung PPH (2021) Diagnostic performances of common nucleic acid tests for SARS-CoV-2 in hospitals and clinics: a systematic review and meta-analysis. Lancet Microb. https://doi.org/10.1016/S2666-5247(21)00214-7. Online ahead of print
Mistry DA, Wang JY, Moeser ME et al (2021) BMC Infect Dis 21(1):828. https://doi.org/10.1186/s12879-021-06528-3
https://www.who.int/news-room/q-a-detail/coronavirus-disease-covid-19. Accessed 24 Oct 2021
Huang P, Liu T, Huang L, Liu H, Lei M, Xu W et al (2020) Use of chest CT in combination with negative RT-PCR assay for the 2019 novel coronavirus but high clinical suspicion. Radiology 295(1):22–23
Xie X, Zhong Z, Zhao W, Zheng C, Wang F, Liu J (2020) Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing. Radiology 296(2):E41–E45
Jafari R, Ashtari S, Pourhoseingholi MA et al (2021) Identification, monitoring, and prediction of disease severity in patients with COVID-19 pneumonia based on chest computed tomography scans: a retrospective study. Adv Exp Med Biol 1321:265–275
Zhou S, Wang Y, Zhu T et al (2020) CT features of coronavirus disease 2019 (COVID-19) pneumonia in 62 patients in Wuhan, China. AJR Am J Roentgenol 214(6):1287–1294
Chung M, Bernheim A, Mei X et al (2020) CT imaging features of 2019 novel coronavirus (2019-nCoV). Radiology 295(1):202–207
Udugama B, Kadhiresan P, Kozlowski HN et al (2020) Diagnosing COVID-19: the disease and tools for detection. ACS Nano 14(4):3822–3835
Wasilewski PG, Mruk B, Mazur S et al (2020) COVID-19 severity scoring systems in radiological imaging - a review. Pol J Radiol 85:e361–e368. https://doi.org/10.5114/pjr.2020.98009
Gross A, Albrecht T (2021) One year of COVID-19 pandemic: what we radiologists have learned about imaging. Rofo. https://doi.org/10.1055/a-1522-3155. Online ahead of print
Chu K, Alharahsheh B, Garg N et al (2021) Evaluating risk stratification scoring systems to predict mortality in patients with COVID-19. BMJ Health Care Inform 28(1):e100389. https://doi.org/10.1136/bmjhci-2021-100389
Kwee RM, Adams HJA, Kwee TC (2021) Diagnostic performance of CO-RADS and the RSNA classification system in evaluating COVID-19 at chest CT: a meta-analysis. Radiol Cardiothorac Imaging 3(1):e200510. https://doi.org/10.1148/ryct.2021200510
Yang D, Martinez C, Visuña L et al (2021) Detection and analysis of COVID-19 in medical images using deep learning techniques. Sci Rep 11(1):19638. https://doi.org/10.1038/s41598-021-99015-3
Yao XJ, Zhu ZQ, Wang SH et al (2021) CSGBBNet: an explainable deep learning framework for COVID-19 detection. Diagnostics (Basel) 11(9):1712. https://doi.org/10.3390/diagnostics11091712
Pourhoseingholi A, Vahedi M, Chaibakhsh S et al (2021) Deep learning analysis in prediction of COVID-19 infection status using chest CT scan features. Adv Exp Med Biol 1327:139–147
Hansell DM, Bankier AA, MacMahon H et al (2008) Fleischner society: glossary of terms for thoracic imaging. Radiology 246(3):697–722
Schoen K, Horvat N, Guerreiro NFC et al (2019) Spectrum of clinical and radiographic findings in patients with diagnosis of H1N1 and correlation with clinical severity. BMC Infect Dis 19(1):964. https://doi.org/10.1186/s12879-019-4592-0
Chang YC, Yu CJ, Chang SC et al (2005) Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT. Radiology 236(3):1067–1075
Kutner MH, Nachtsheim CJ, Neter J et al (2005) Applied linear statistical models. McGraw-Hill, New York. ISBN-13: 978-0073108742
Chollet F, Allaire JJ (2018) Deep learning with R. Manning Publications, Shelter Island. ISBN-13: 978-1617295546
Gong K, Wu D, Arru CD et al (2021) A multi-center study of COVID-19 patient prognosis using deep learning-based CT image analysis and electronic health records. Eur J Radiol 139:109583. https://doi.org/10.1016/j.ejrad.2021.109583
Lassau N, Ammari S, Chouzenoux E et al (2021) Integrating deep learning CT-scan model, biological and clinical variables to predict severity of COVID-19 patients. Nat Commun 12(1):634. https://doi.org/10.1038/s41467-020-20657-4
Weikert T, Rapaka S, Grbic S et al (2021) Prediction of patient management in COVID-19 using deep learning-based fully automated extraction of cardiothoracic CT metrics and laboratory findings. Korean J Radiol 22(6):994–1004
Shiri I, Sorouri M, Geramifar P et al (2021) Machine learning-based prognostic modeling using clinical data and quantitative radiomic features from chest CT images in COVID-19 patients. Comput Biol Med 132:104304. https://doi.org/10.1016/j.compbiomed.2021.104304
Purkayastha S, Xiao Y, Jiao Z et al (2021) Machine learning-based prediction of COVID-19 severity and progression to critical illness using CT imaging and clinical data. Korean J Radiol 22(7):1213–1224
Du R, Tsougenis ED, Ho JWK et al (2021) Machine learning application for the prediction of SARS-CoV-2 infection using blood tests and chest radiograph. Sci Rep 11(1):14250. https://doi.org/10.1038/s41598-021-93719-2
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature
About this protocol
Cite this protocol
Sahebkar, A. et al. (2022). A Deep Learning Approach to Identify Chest Computed Tomography Features for Prediction of SARS-CoV-2 Infection Outcomes. In: Guest, P.C. (eds) Multiplex Biomarker Techniques. Methods in Molecular Biology, vol 2511. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2395-4_30
Download citation
DOI: https://doi.org/10.1007/978-1-0716-2395-4_30
Published:
Publisher Name: Humana, New York, NY
Print ISBN: 978-1-0716-2394-7
Online ISBN: 978-1-0716-2395-4
eBook Packages: Springer Protocols