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Fundamental Tick Vaccinomic Approach to Evade Host Autoimmune Reaction

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Vaccine Design

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2411))

Abstract

Ticks are obligate hematophagous ectoparasites that infect domestic animals, humans, and wildlife. Ticks can transmit a wide range of pathogens (viruses, rickettsia, bacteria, parasites, etc.), and some of those are of zoonotic importance. Tick-borne diseases have a negative economic impact in several tropical and subtropical countries. With climate change, tick distribution and tick-associated pathogens have increased. Currently, tick control procedures have more environmental drawbacks and there are pitfalls in vaccination process. Since vaccinations have helped to prevent several diseases and infections, several vaccination trials are ongoing to control ticks and tick-borne pathogens. However, autoimmune reactions to vaccinations are reported as an adverse reaction since vaccines were used to protect against disease in humans and animals. The antibodies against the vaccine antigen might harm similar antigen in the host. Therefore, in this chapter, we attempt to shed light on the importance of raising awareness of possible adverse events associated with vaccinations and the methods that should be used to address this problem. In silico and lab work should be performed ahead of the vaccination process to evaluate the vaccine candidates and avoid the vaccination opposing consequences.

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Acknowledgments

The research was supported by a joint research grant from the Science and Technology Development Fund [STDF], Egypt (Grant Number 42839) and the Japan Society for the Promotion of Science [JSPS] Bilateral Program, Japan (Grant Number JPJSBP120206002).

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Author notes

  1. Seham H. M. Hendawy and Heba F. Alzan contributed equally to this work.

Authors and Affiliations

  1. Parasitology and Animal Diseases Department, Veterinary Research Division, National Research Centre, Cairo, Egypt

    Seham H. M. Hendawy, Heba F. Alzan & Mona S. Mahmoud

  2. Tick and Tick-Borne Diseases Research Unit, Veterinary Research Division, National Research Centre, Cairo, Egypt

    Seham H. M. Hendawy, Heba F. Alzan & Mona S. Mahmoud

  3. Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA, USA

    Heba F. Alzan

  4. Laboratory of Infectious Diseases, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan

    Tetsuya Tanaka

Authors
  1. Seham H. M. Hendawy
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  2. Heba F. Alzan
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  3. Tetsuya Tanaka
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  4. Mona S. Mahmoud
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Corresponding author

Correspondence to Tetsuya Tanaka .

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Editors and Affiliations

  1. Lankenau Institute for Medical Research, Wynnewood, PA, USA

    Sunil Thomas

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Hendawy, S.H.M., Alzan, H.F., Tanaka, T., Mahmoud, M.S. (2022). Fundamental Tick Vaccinomic Approach to Evade Host Autoimmune Reaction. In: Thomas, S. (eds) Vaccine Design. Methods in Molecular Biology, vol 2411. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1888-2_20

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  • DOI: https://doi.org/10.1007/978-1-0716-1888-2_20

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