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Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview

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Cytotoxic T-Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2325))

Abstract

Involvement of T lymphocytes in kidney transplantation is a well-developed topic; however, most of the scientific interest focused on the different type of CD4+ lymphocyte subpopulations. Few authors, instead, investigated the role of CD8+ T cells in renal transplantation and how deleterious they can be to long-term allograft survival. Recently, there has been a renewed interest in the CD8+ T cells involvement in the transplantation field with the aim to investigate the immunological mechanisms underlying the infiltration of CD8+ T cells and their biological functions in human kidney allografts. The purpose of the present review is to highlight the role of allo-reactive cytotoxic T lymphocytes (CTLs) CD8+ subset in allograft kidney recipients and their related clinical complications.

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Author information

Authors and Affiliations

  1. Nephrology, Dialysis and Transplantation Unit, Department of Medical and Surgical Sciences, Faculty of Medicine, University of Foggia, Foggia, Italy

    Federica Rascio

  2. Experimental Biology, Department of Emergency and Organ Transplantation, Faculty of Medicine, University of Bari “Aldo Moro”, Bari, Italy

    Paola Pontrelli

  3. Nephrology Unit, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy

    Giuseppe Grandaliano

  4. Department of Translational Medicine and Surgery, Faculty of Medicine, Catholic University of the Sacred Heart, Rome, Italy

    Giuseppe Grandaliano

Authors
  1. Federica Rascio
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  2. Paola Pontrelli
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  3. Giuseppe Grandaliano
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Editor information

Editors and Affiliations

  1. Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy

    Margherita Gigante

  2. Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy

    Elena Ranieri

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Rascio, F., Pontrelli, P., Grandaliano, G. (2021). Cytotoxic T Lymphocytes (CTLs) and Kidney Transplantation: An Overview. In: Gigante, M., Ranieri, E. (eds) Cytotoxic T-Cells. Methods in Molecular Biology, vol 2325. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1507-2_14

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  • DOI: https://doi.org/10.1007/978-1-0716-1507-2_14

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1506-5

  • Online ISBN: 978-1-0716-1507-2

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