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Scoring Sepsis Severity in Mice

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Sepsis

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2321))

Abstract

A reliable scoring system that predicts the development of sepsis, septic shock, and death enables comparison of disease severity and treatment outcomes in animal models of sepsis. Mice are used in the majority of preclinical sepsis studies. We describe a murine sepsis score that evaluates seven clinical variables in an experimental mouse model of polymicrobial sepsis.

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Author information

Authors and Affiliations

  1. Department of Surgery, Western University, London, ON, Canada

    Tina S. Mele

Authors
  1. Tina S. Mele
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Corresponding author

Correspondence to Tina S. Mele .

Editor information

Editors and Affiliations

  1. Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center at El Paso, El Paso, TX, USA

    Wendy E. Walker

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Mele, T.S. (2021). Scoring Sepsis Severity in Mice. In: Walker, W.E. (eds) Sepsis. Methods in Molecular Biology, vol 2321. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1488-4_13

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  • DOI: https://doi.org/10.1007/978-1-0716-1488-4_13

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1487-7

  • Online ISBN: 978-1-0716-1488-4

  • eBook Packages: Springer Protocols

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