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Mouse Models of Kidney Fibrosis

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Myofibroblasts

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2299))

Abstract

Chronic kidney disease (CKD) affects over 10% of the worldwide population and kidney fibrosis is a main driver of CKD and considered a therapeutic target. The mechanisms leading to kidney fibrosis are highly complexed and can be best studied in rodent models. Here we describe the most commonly used kidney fibrosis models in mice, the unilateral ureteral obstruction (UUO) model and the ischemia reperfusion injury (IRI) model. Both models are easy to learn and can be applied in animals of different age, sex, and strain.

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Authors and Affiliations

  1. Institute of Experimental Medicine and Systems Biology, RWTH Aachen University Hospital, Aachen, Germany

    Rafael Kramann & Sylvia Menzel

  2. Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands

    Rafael Kramann

Authors
  1. Rafael Kramann
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  2. Sylvia Menzel
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Editor information

Editors and Affiliations

  1. Laboratory of Tissue Repair and Regeneration, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada

    Boris Hinz

  2. Matrix and Mechanobiology Program, Massachusetts General Hospital, Charlestown, MA, USA

    David Lagares

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Kramann, R., Menzel, S. (2021). Mouse Models of Kidney Fibrosis. In: Hinz, B., Lagares, D. (eds) Myofibroblasts. Methods in Molecular Biology, vol 2299. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1382-5_22

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  • DOI: https://doi.org/10.1007/978-1-0716-1382-5_22

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-1381-8

  • Online ISBN: 978-1-0716-1382-5

  • eBook Packages: Springer Protocols

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