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Use of Golden Syrian Hamster as an Animal Model to Study Leptospirosis-Associated Immune Responses

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Leptospira spp.

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2134))

Abstract

Experimental infections greatly contribute to further deepen our knowledge of infectious diseases. In the case of leptospirosis, hamsters as well as gerbils and guinea pigs have been used as animal models of acute leptospirosis in studying the pathophysiology of the disease. Here we describe a typical Leptospira infection using golden Syrian hamsters. We will also present techniques we use to study the resulting bacterial burden and gene expression patterns in the host in order to decipher the innate immune response to leptospirosis.

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Author information

Authors and Affiliations

  1. Immunity and Inflammation Group, Institut Pasteur in New Caledonia, Institut Pasteur International Network, Noumea, New Caledonia, France

    Julie Cagliero, Karl Huet & Mariko Matsui

Authors
  1. Julie Cagliero
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  2. Karl Huet
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  3. Mariko Matsui
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Corresponding author

Correspondence to Julie Cagliero .

Editor information

Editors and Affiliations

  1. Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan

    Nobuo Koizumi

  2. Unité de Biologie des Spirochètes, Institut Pasteur, Paris, France

    Mathieu Picardeau

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Cagliero, J., Huet, K., Matsui, M. (2020). Use of Golden Syrian Hamster as an Animal Model to Study Leptospirosis-Associated Immune Responses. In: Koizumi, N., Picardeau, M. (eds) Leptospira spp.. Methods in Molecular Biology, vol 2134. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0459-5_22

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  • DOI: https://doi.org/10.1007/978-1-0716-0459-5_22

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0458-8

  • Online ISBN: 978-1-0716-0459-5

  • eBook Packages: Springer Protocols

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