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Systematic Screening of Viral Entry Inhibitors Using Surface Plasmon Resonance

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Targeting Enzymes for Pharmaceutical Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2089))

Abstract

Surface plasmon resonance (SPR) analytical method was initially used as biosensor for analyzing diverse biomolecular interactions and recently gained important place in the drug discovery. Here, I describe the procedures for screening of inhibitors against the viral proteins using the SPR. Using the described procedures, in the past, we were able to identify several antiviral products that interfere viral-host receptor proteins interactions.

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Acknowledgment

This work was supported by grants from JST and AIST to P.K.R.K.

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Authors and Affiliations

  1. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba City, Ibaraki, Japan

    Penmetcha K. R. Kumar

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  1. Penmetcha K. R. Kumar
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Correspondence to Penmetcha K. R. Kumar .

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Editors and Affiliations

  1. Department of Biotechnology, Agricultural University of Athens, Athens, Greece

    Nikolaos E. Labrou

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Kumar, P.K.R. (2020). Systematic Screening of Viral Entry Inhibitors Using Surface Plasmon Resonance. In: Labrou, N. (eds) Targeting Enzymes for Pharmaceutical Development. Methods in Molecular Biology, vol 2089. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-0163-1_8

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  • DOI: https://doi.org/10.1007/978-1-0716-0163-1_8

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-0162-4

  • Online ISBN: 978-1-0716-0163-1

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