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Development of an IRF-1 Based Proliferation Control System

  • Chapter
Cell Engineering

Part of the book series: Cell Engineering ((CEEN,volume 1))

Abstract

Mammalian cell cultures are the preferred production system for secreted pharmaceutical proteins (Hauser, 1997). Life of a mammal begins with fertilization of the oocyte that divides and proliferates until the animal reaches its mature size. Further cell growth is tightly controlled. Proliferation and cell death are balanced to keep the total cell mass essentially constant, while the synthesis and secretion of cellular products continues. Despite rapid progress in the understanding of growth regulatory mechanisms, tumorigenic growth due the loss of proliferation control of a single body cell initially is still a leading cause of disease and death.

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Authors and Affiliations

  1. Department of Gene Regulation and Differentiation, GBF - National Research Center for Biotechnology, Mascheroder Weg 1, D- 38124, Braunschweig, Germany

    P. P. Mueller, C. Geserick, K. Schroeder & H. Hauser

  2. ITQB/IBET- Instituto de Tecnologia Quimica e Biologica/Instituto de Biologica Experimental e Tecnologia, Apartado 12, P- 2780, Oeiras, Portugal

    A. V. Carvalhal, J. L. Moreira & M. J. T. Carrondo

  3. Novo Nordisk, Niels Steensens Vej 1, 2820, Gentofte, Denmark

    C. Geserick

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  1. P. P. Mueller
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  2. A. V. Carvalhal
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  3. J. L. Moreira
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  4. C. Geserick
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  6. M. J. T. Carrondo
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  7. H. Hauser
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  1. School of Chemical Engineering, The University of Birmingham, Edgbaston, Birmingham, UK

    Mohamed Al-Rubeai

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© 1999 Kluwer Academic Publishers

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Mueller, P.P. et al. (1999). Development of an IRF-1 Based Proliferation Control System. In: Al-Rubeai, M. (eds) Cell Engineering. Cell Engineering, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-0-585-37971-5_8

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  • DOI: https://doi.org/10.1007/978-0-585-37971-5_8

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