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Correlations of Cellular Activities in the Nervous System: Physiological and Methodological Considerations

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Coordinated Activity in the Brain

Part of the book series: Springer Series in Computational Neuroscience ((NEUROSCI,volume 2))

Abstract

Rhythms (cycles, oscillations) and synchronization processes pervade all aspects of the living and nonliving, from circadian rhythms to individual habits and traits (Glass, 2001; Pikovsky et al., 2001). The distributed nature of cognition implies that distinct brain areas must somehow coordinate their activity: cognition, whether in the form of perception or motor actions, results from the integrated spatiotemporal coordinated activity of cell populations in the nervous system, including both glial and neuronal elements. Because the system’s collective behavior is difficult, if not impossible, to deduce from its individual components, the determination of brain-coordinated activity at adequate levels of description becomes fundamental to the understanding of nervous system function and its relation to behavior. Some questions arise: what variables are best suited to measure these correlations in activity? What order parameters should be used to characterize coordinated activity among cellular populations and how do these activity patterns relate to behavioral responses? What level of description should be used? This chapter summarizes some physiological and methodological considerations to aid the science practitioner in the study of correlated activity patterns in nervous systems.

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Acknowledgments

Our research is supported by the Natural Science and Engineering Research Council of Canada (NSERC), the Hospital for Sick Children Foundation, and the Bial Foundation.

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Authors and Affiliations

  1. Neurosciences and Mental Health Program, Division of Neurology, Department of Paediatrics and Institute of Medical Science, Brain and Behaviour Centre, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

    Jose Luis Perez Velazquez

  2. Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

    Ramon Guevara Erra & Luis Garcia Dominguez

  3. Clinical Neurophysiology Laboratory, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada

    Richard Wennberg

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Correspondence to Jose Luis Perez Velazquez .

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  1. Inst. Medical Science, Dept. Paediatrics, University of Toronto, University Ave.555, Toronto , M5G 1X8, Canada

    Jose Luis Perez Velazquez

  2. Toronto Western Hospital, University Health Network, Bathurst Street 399, Toronto, M5T 2S8, Canada

    Richard Wennberg

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Perez Velazquez, J.L., Erra, R.G., Wennberg, R., Dominguez, L.G. (2009). Correlations of Cellular Activities in the Nervous System: Physiological and Methodological Considerations. In: Velazquez, J., Wennberg, R. (eds) Coordinated Activity in the Brain. Springer Series in Computational Neuroscience, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-0-387-93797-7_1

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