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Normal Distribution, Variants, Pitfalls, and Artifacts

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Hybrid PET/CT and SPECT/CT Imaging

Abstract

18F-FDG is an analog of glucose and therefore has a similar biodistribution. 18F-FDG enters the cells by the same transport mechanism as glucose and is intracellularly phosphorylated by a hexokinase into 18F-FDG-6-phosphate (18F-FDG-6-P). As an indicator of glucose metabolism, 18F-FDG is not taken up only by malignant cells. In tissues with a low concentration of glucose-6-phosphatase, such as the brain, the myocardium, and most malignant cells, 18F-FDG-6-P does not follow further enzymatic pathways and accumulates proportionally to the glycolytic cellular rate.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel

    Ora Israel

  2. R. Rappaport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel

    Ora Israel

  3. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA

    Dominique Delbeke MD, PhD

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  1. Ora Israel
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Correspondence to Ora Israel .

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Editors and Affiliations

  1. Medical Center, Vanderbilt University, 21st Ave. S. & Garland 1161, Nashville, 37232-2675, U.S.A.

    Dominique Delbeke

  2. Dept. Nuclear Medicine, Rambam Medical Centre, Bat-Galim, Haifa, 35 254, Israel

    Ora Israel

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Israel, O., Delbeke, D. (2010). Normal Distribution, Variants, Pitfalls, and Artifacts. In: Delbeke, D., Israel, O. (eds) Hybrid PET/CT and SPECT/CT Imaging. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92820-3_2

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