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Protein Structure Prediction

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Bioinformatics

Abstract

Owing to significant efforts in genome sequencing over nearly three decades (McPherson et al. 2001; Venter et al. 2001), gene sequences from many organisms have been deduced. Over 100 million nucleotide sequences from over 300 thousand different organisms have been deposited in the major DNA databases, DDBJ/EMBL/GenBank (Benson et al. 2003; Miyazaki et al. 2003; Kulikova et al. 2004), totaling almost 200 billion nucleotide bases (about the number of stars in the Milky Way). Over 5 million of these nucleotide sequences have been translated into amino acid sequences and deposited in the UniProtKB database (Release 12.8) (Bairoch et al. 2005). The protein sequences in UniParc triple this number. However, the protein sequences themselves are usually insufficient for determining protein function as the biological function of proteins is intrinsically linked to three dimensional protein structure (Skolnick et al. 2000).

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Authors and Affiliations

  1. Center for Bioinformatics and Department of Molecular Bioscience, University of Kansas, Lawrence, KS, 66047, USA

    Yang Zhang

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  1. Sitao Wu
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Correspondence to Yang Zhang .

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Editors and Affiliations

  1. Inst. Molecular Bioscience, University of Queensland, St.Lucia, 4072, Australia

    David Edwards

  2. Dept. Plant & Microbial Biology, University of California, Berkeley, Koshland Hall 111, Berkeley, 94720, U.S.A.

    Jason Stajich

  3. e-Health Research Centre, Adelaide St. 300, Brisbane, 4000, Australia

    David Hansen

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Wu, S., Zhang, Y. (2009). Protein Structure Prediction. In: Edwards, D., Stajich, J., Hansen, D. (eds) Bioinformatics. Springer, New York, NY. https://doi.org/10.1007/978-0-387-92738-1_11

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