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Global Perspectives of Antibiotic Resistance

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Antimicrobial Resistance in Developing Countries

Abstract

The threat of antibiotic resistance is growing at an alarming pace, perhaps more rapidly in developing countries. Aside from the abuse of antibiotics, a number of circumstances converge to this rapid growth and spread, ranging from the biological traits that bacteria deploy to face antibiotics, which we are still trying to understand, to regulatory and financial issues behind antibiotic abuse. And, aside from the more-difficult-to-cure side of resistance, which is bad enough, bacteria are evolving to be more competent to face environmental stress, which includes antibiotics, present and future ones. In developing countries, we face peculiarities that go from antibiotic self-prescription to poor sanitary conditions, even at hospitals, that foster the threat of particular multi-resistant pathogens that are not common in developed countries and against which no new antibiotics are being investigated. In addition to the local repercussions of these peculiarities upon resistance trends, it is important to realize that these can easily cross borders in this era of globalization. A worldwide strategy must be developed and enforced if we are to have a good start at the post-antibiotic era.

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References

  • Aiello, A.E. and Larson, E.L. (2003) “Antibacterial cleaning and hygiene products as emerging risk factor for antibiotic resistance in the community.” Lancet Infectious Diseases 3, 501–506.

    Article  PubMed  Google Scholar 

  • Amábile-Cuevas, C.F. (1993) Origin, evolution and spread of antibiotic resistance genes. RG Landes, Austin.

    Google Scholar 

  • Amábile-Cuevas, C.F. (2003) “Gathering of resistance genes in gram-negative bacteria: an overview”. In: C.F. Amábile-Cuevas (Ed.), Multiple drug resistant bacteria. Horizon Scientific Press, Wymondham, UK, pp. 9–31.

    Google Scholar 

  • Amábile-Cuevas, C.F., Cabrera, R., Fuchs, L.Y. and Valenzuela, F. (1998) “Antibiotic resistance and prescription practices in developing countries.” Methods in Microbiology 27, 587–594.

    Article  Google Scholar 

  • Amábile-Cuevas, C.F. and Chicurel, M.E. (1992) “Bacterial plasmids and gene flux.” Cell 70, 189–199.

    Article  PubMed  Google Scholar 

  • Balsalobre, L., Ferrándiz, M.J., Liñares, J., Tubau, F. and de la Campa, A.G. (2003) “Viridans group streptococci are donors in horizontal transfer of topoisomerase IV genes to Streptococcus pneumoniae.” Antimicrobial Agents and Chemotherapy 47, 2072–2081.

    Article  CAS  PubMed  Google Scholar 

  • Beaber, J.W., Hochhut, B. and Waldor, M.K. (2003) “SOS response promotes horizontal dissemination of antibiotic resistance genes.” Nature 427, 72–74.

    Article  PubMed  Google Scholar 

  • Becker, D., Selbach, M., Rollenhagen, C., Ballmaier, M., Meyer, T.F., Mann, M. and Bumann, D. (2006) “Robust Salmonella metabolism limits possibilities for new antimicrobials.” Nature 440, 303–307.

    Article  CAS  PubMed  Google Scholar 

  • Brown, E.W., LeClerc, J.E., Li, B., Payne, W.L. and Cebula, T.S. (2001) “Phylogenetic evidence for horizontal transfer of mutS alleles among naturally occurring Escherichia coli strains.” Journal of Bacteriology 183, 1631–1644.

    Article  CAS  PubMed  Google Scholar 

  • Buxton, I.L.O. (2006) “Principles of prescription order writing and patient compliance.” In: L.L. Brunton, J.S. Lazo and K.L. Parker (Ed.), The pharmacological basis of therapeutics. McGraw-Hill, New York, pp. 1777–1786.

    Google Scholar 

  • Calva, J.J., Niebla-Pérez, A., Rodríguez-Lemoine, V., Santos, J.I. and Amábile-Cuevas, C.F. (1996) “Antibiotic usage and antibiotic resistance in Latin America.” In: C.F. Amábile-Cuevas (Ed.), Antibiotic resistance: from molecular basics to therapeutic options. R.G. Landes/Chapman & Hall, Austin/New York, pp. 73–97.

    Google Scholar 

  • Casellas, J.M. and Quinteros, M.G. (2007) “A Latin American “point de vue” on the epidemiology, control, and treatment options of infections caused by extended-spectrum beta-lactamase producers.” In: C.F. Amábile-Cuevas (Ed.), Antimicrobial resistance in bacteria. Horizon Bioscience, Wymondham, pp. 99–122.

    Google Scholar 

  • Courvalin, P. (1990) “Plasmid-mediated 4-quinolone resistance: a real or apparent absence?” Antimicrobial Agents and Chemotherapy 34, 681–684.

    CAS  PubMed  Google Scholar 

  • Davin-Regli, A. and Pagès, J.-M. (2007) “Regulation of efflux pumps in Enterobacteriaceae: genetic and chemical effectors.” In: C.F. Amábile-Cuevas (Ed.), Antimicrobial resistance in bacteria. Horizon Bioscience, Wymondham, UK, pp. 55–75.

    Google Scholar 

  • Delissalde, F. and Amábile-Cuevas, C.F. (2004) “Comparison of antibiotic susceptibility and plasmid content, between biofilm producing and non-producing clinical isolates of Pseudomonas aeruginosa.” International Journal of Antimicrobial Agents 24, 405–408.

    Article  CAS  PubMed  Google Scholar 

  • Demple, B. and Amábile-Cuevas, C.F. (2003) “Multiple resistance mediated by individual genetic loci.” In: C.F. Amábile-Cuevas (Ed.), Multiple drug resistant bacteria. Horizon Scientific Press, Wymondham, UK, pp. 61–80.

    Google Scholar 

  • Díaz-Mejía, J.J., Amábile-Cuevas, C.F., Rosas, I. and Souza, V. (2008) “An analysis of the evolutionary relationships of integron integrases, with emphasis on the prevalence of class 1 integron in Escherichia coli isolates from clinical and environmental origins.” Microbiology 154, 94–102.

    Article  PubMed  Google Scholar 

  • Fuchs, L.Y., Reyna, F., Chihu, L. and Carrillo, B. (1996) “Molecular aspects of fluoroquinolone resistance.” In: C.F. Amábile-Cuevas (Ed.), Antibiotic resistance: from molecular basics to therapeutic options. Landes/Chapman & Hall, Austin/New York, pp. 147–174.

    Google Scholar 

  • Gilbert, P., McBain, A. and Lindsay, S. (2007) “Biofilms, multi-resistance, and persistence.” In: C.F. Amábile-Cuevas (Ed.), Antimicrobial resistance in bacteria. Horizon Bioscience, Wymondham, UK, pp. 77–98.

    Google Scholar 

  • Heinemann, J.A. and Goven, J. (2007) “The social context of drug discovery and safety testing.” In: C.F. Amábile-Cuevas (Ed.), Antimicrobial resistance in bacteria. Horizon Bioscience, Wymondham, pp. 179–196.

    Google Scholar 

  • Heinemann, J.A. and Silby, M.W. (2003) “Horizontal gene transfer and the selection of antibiotic resistance.” In: C.F. Amábile-Cuevas (Ed.), Multiple drug resistant bacteria. Horizon, Wymondham, pp. 161–178.

    Google Scholar 

  • Hooper, D.C., Wolfson, J.S., Souza, K.S., Ng, E.Y., McHugh, G.L. and Swartz, M.N. (1989) “Mechanisms of quinolone resistance in Escherichia coli: characterization of nfxB and cfxB, two mutant resistance loci decreasing norfloxacin accumulation.” Antimicrobial Agents and Chemotherapy 33, 283–290.

    CAS  PubMed  Google Scholar 

  • Jiménez-Arribas, G., Léautaud, V. and Amábile-Cuevas, C.F. (2001) “Regulatory locus soxRS partially protects Escherichia coli against ozone.” FEMS Microbiology Letters 195, 175–177.

    Article  PubMed  Google Scholar 

  • Miller, C., Thomsen, L.E., Gaggero, C., Mosseri, R., Ingmer, H. and Cohen, S.N. (2004) “SOS response induction by β-lactams and bacterial defense against antibiotic lethality.” Science 305, 1629–1631.

    Article  CAS  PubMed  Google Scholar 

  • Outterson, K., Samora, J.B. and Keller-Cuda, K. (2007) “Will longer antimicrobial patents improve global public health?” Lancet Infectious Diseases 7, 559–566.

    Article  PubMed  Google Scholar 

  • Robicsek, A., Strahilevitz, J., Jacoby, G.A., Macielag, M., Abbanat, D., Park, C.H., Bush, K. and Hooper, D.C. (2006) “Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase.” Nature Medicine 12, 83–88.

    Article  CAS  PubMed  Google Scholar 

  • Tran, J.H. and Jacoby, G.A. (2002) “Mechanism of plasmid-mediated quinolone resistance.” Proceedings of the National Academy of Sciences USA 99, 5638–5642.

    Google Scholar 

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Correspondence to Carlos F. Amábile-Cuevas .

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Amábile-Cuevas, C.F. (2010). Global Perspectives of Antibiotic Resistance. In: Sosa, A., Byarugaba, D., Amábile-Cuevas, C., Hsueh, PR., Kariuki, S., Okeke, I. (eds) Antimicrobial Resistance in Developing Countries. Springer, New York, NY. https://doi.org/10.1007/978-0-387-89370-9_1

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