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Prognostic Potential Of The Pretherapeutic Tumor Oxygenation Status

  • Conference paper
Oxygen Transport to Tissue XXX

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 645))

Abstract

Hypoxia, a characteristic feature of locally advanced solid tumors, has emerged as a key factor of the tumor pathophysiome, since it can promote tumor progression and resistance to therapy. Independent of established prognostic parameters, such as clinical tumor stage, histology, histological grade and nodal status, hypoxia has been identified as an adverse prognostic factor for patient outcome. Studies of pretreatment tumor hypoxia involving direct assessment (polarographic oxygen tension measurements) have suggested a poor prognosis for patients with hypoxic tumors. These investigations indicate a worse disease-free survival for patients with hypoxic cancers of the uterine cervix or soft tissue sarcomas. In head & neck cancers, the studies suggest that pretherapeutic hypoxia is prognostic for survival and local control.

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Author information

Authors and Affiliations

  1. Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany

    Peter Vaupel

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  1. Peter Vaupel
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Editors and Affiliations

  1. Uppsala University, Uppsala, Sweden

    Per Liss  & Peter Hansell  & 

  2. University of Maryland Baltimore County, Baltimore, MD, USA

    Duane F. Bruley

  3. University Hospital of North Durham, Durham, UK

    David K. Harrison

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Vaupel, P. (2009). Prognostic Potential Of The Pretherapeutic Tumor Oxygenation Status. In: Liss, P., Hansell, P., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXX. Advances in Experimental Medicine and Biology, vol 645. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-85998-9_36

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