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CD4 + and CD8 + T-Cell Immune Responses in West Nile Virus Infection

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West Nile Encephalitis Virus Infection

Part of the book series: Emerging Infectious Diseases of the 21 Century ((EIDC))

Abstract

CD4+ and CD8+ T cells, in combination with the innate and humoral immune responses, are critical for recovery of mice from infection with West Nile virus. Mouse models of West Nile virus encephalitis are therefore excellently suited to investigate the role of T cells in the balance between viral clearance and CNS disease following infection with a cytopathic and neurotropic virus. Here we review the in vitro properties of West Nile virus-immune T cell responses, their in vivo disease ameliorating and potentiating effects, and the contribution of the different T cell effector functions to disease outcome.

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  1. Division of Immunology and Genetics John Curtin School of Medical Research, The Australian National University, Canberra, Australia

    Mario Lobigs, Arno Müllbacher & Matthias Regner

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  1. Mario Lobigs
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  2. Arno Müllbacher
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  3. Matthias Regner
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Lobigs, M., Müllbacher, A., Regner, M. (2009). CD4 + and CD8 + T-Cell Immune Responses in West Nile Virus Infection. In: West Nile Encephalitis Virus Infection. Emerging Infectious Diseases of the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-0-387-79840-0_13

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