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Microneme Proteins in Apicomplexans

  • Chapter
Molecular Mechanisms of Parasite Invasion

Part of the book series: Subcellular Biochemistry ((SCBI,volume 47))

Abstract

The invasive stages (zoites) of most apicomplexan parasites are polarised cells that use their actinomyosin-powered gliding motility or “glideosome” system to move over surfaces, migrate through biological barriers and invade and leave host cells. Central to these processes is the timely engagement and disengagement of specific receptors upon the regulated release of apical invasion proteins from parasite secretory organelles (micronemes, rhoptries). In this short review, we summarise recent progress on identification and functional characterisation of apical invasion proteins mobilised to the parasite surface from the microneme organelles. We have restricted our focus to Toxoplasma, Eimeria, Cryptosporidium and the nonerythrocytic stages of Plasmodium because these organisms have been the most intensively studied apicomplexans that invade nucleated cells and because invasion by erythrocytic stages of Plasmodium is covered in the next chapter.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Michigan School of Medicine, Ann Arbor, Michigan, USA, 48109

    Vern B. Carruthers

  2. Division of Microbiology, Institute for Animal Health, Compton Newbury, Berkshire, UK

    Fiona M. Tomley

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  1. Vern B. Carruthers
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  2. Fiona M. Tomley
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Correspondence to Vern B. Carruthers .

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Editors and Affiliations

  1. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

    Barbara A. Burleigh PhD

  2. Department of Biological Sciences, Imperial College, London, UK

    Dominique Soldati-Favre PhD

  3. Département de Microbiologie et Medecine Moléculaire, Université de Genève, Geneve, Switzerland

    Dominique Soldati-Favre PhD

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Carruthers, V.B., Tomley, F.M. (2008). Microneme Proteins in Apicomplexans. In: Burleigh, B.A., Soldati-Favre, D. (eds) Molecular Mechanisms of Parasite Invasion. Subcellular Biochemistry, vol 47. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78267-6_2

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