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Relating Alternative Splicing to Proteome Complexity and Genome Evolution

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Alternative Splicing in the Postgenomic Era

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 623))

Abstract

Prior to genomics, studies of alternative splicing primarily focused on the function and mechanism of alternative splicing in individual genes and exons. This has changed dramatically since the late 1990s. High-throughput genomics technologies, such as EST sequencing and microarrays designed to detect changes in splicing, led to genome-wide discoveries and quantification of alternative splicing in a wide range of species from human to Arabidopsis.1,2 Consensus estimates of AS frequency in the human genome grew from less than 5% in mid-1990s to as high as 60–74% now.3 The rapid growth in sequence and microarray data for alternative splicing has made it possible to look into the global impact of alternative splicing on protein function and evolution of genomes. In this chapter, we review recent research on alternative splicing’s impact on proteomic complexity and its role in genome evolution.

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Authors and Affiliations

  1. Department of Internal Medicine Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA

    Yi Xing

  2. Department of Chemistry and Biochemistry, Molecular Biology Institute, USA

    Christopher Lee

  3. Institute for Genomics and Proteomics Center for Computational Biology, University of California, Los Angeles, Los Angeles, California, USA

    Christopher Lee

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  1. Yi Xing
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  2. Christopher Lee
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Correspondence to Christopher Lee .

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Editors and Affiliations

  1. Banting and Best Department of Medical Research and Department of Molecular and Medical Genetics, Terrence Donnelly Center for Cellular and Biomedical Research, University of Toronto, Toronto, Canada

    Benjamin J. Blencowe Ph.D.

  2. Department of Genetics and Development Biology, University of Connecticut Health Center, Farmington, Connecticut, USA

    Brenton R. Graveley Ph.D.

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Xing, Y., Lee, C. (2007). Relating Alternative Splicing to Proteome Complexity and Genome Evolution. In: Blencowe, B.J., Graveley, B.R. (eds) Alternative Splicing in the Postgenomic Era. Advances in Experimental Medicine and Biology, vol 623. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77374-2_3

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  • DOI: https://doi.org/10.1007/978-0-387-77374-2_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-77373-5

  • Online ISBN: 978-0-387-77374-2

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