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Cyanotoxins Workgroup Report

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Cyanobacterial Harmful Algal Blooms: State of the Science and Research Needs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 619))

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References

  • Andrinolo D, Iglesias V, Garcia C, and Lagos N (2002) Toxicokinetics and toxicodynamics of gonyautoxins after an oral toxin dose in cats. Toxicon 40: 699-709.

    Article  PubMed  CAS  Google Scholar 

  • Azevedo S, Carmichael WW, Jochimsen EM, Rinehart KL, Lau S, Shaw GR, Eaglesham GK (2002) Human intoxication by microcystins during renal dialysis treatment in Caruaru-Brazil. Toxicology 181: 441-446.

    Article  PubMed  Google Scholar 

  • Bagu JR, Sykes BD, Craig MM, Holmes CFB (1997) A molecular basis for different interactions of marine toxins with protein phosphatase-1. J-Biol-Chem 8: 5087-5097.

    Google Scholar 

  • Banker R, Carmeli S, Werman M, Teltsch B, Porat R, Sukenik A (2001) Uracil moiety is required for toxicity of the cyanobacterial hepatotoxin cylindrospermopsin. J Tox Environ Health A 62: 281-288.

    Article  CAS  Google Scholar 

  • Beattie KA, Ressler J, Wiegand C, Krause E, Codd GA, Steinberg CEW, Pflugmacher S (2003) Comparative effects and metabolism of two microcystins and nodularin in the brine shrimp Artemia salina. Aquatic Tox 62: 219-226.

    Article  CAS  Google Scholar 

  • Behm D (2003) Coroner cites algae in teen’s death. In Milwaukee Journal Sentinal. Milwaukee.

    Google Scholar 

  • Benson JM, Hutt JA, Rein K, Boggs SE, Barr EB, Fleming LE (2005) The toxicity of microcystin LR in mice following 7 days of inhalation exposure. Toxicon. 45(6):691-8.

    Article  PubMed  CAS  Google Scholar 

  • Brooks WP, and Codd GA (1987) Distribution of Microcystis aeruginosa peptide toxin and interactions with hepatic microsomes in mice. Pharmacology and Toxicology 60: 187-191.

    PubMed  CAS  Google Scholar 

  • Bulera SJ, Eddy SM, Ferguson E, Jatkoe TA, Reindel JF, Bleavins MR, De La Iglesia FA. (2001) RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology. 33(5):1239-58.

    Article  PubMed  CAS  Google Scholar 

  • Byth S (1980) Palm Island Mystery Disease. Medical Journal of Australia 2: 40-42.

    PubMed  CAS  Google Scholar 

  • Camacho FA, Thacker RW (2006) Amphipod herbivory on the freshwater cyanobacterium Lyngbya wollei: chemical stimulants and morphological defenses. Limnology and Oceanography 51: 1870-1875.

    Article  CAS  Google Scholar 

  • Carmichael WW (1994) The toxins of cyanobacteria. Sci Am 270: 78-86.

    PubMed  CAS  Google Scholar 

  • Carmichael WW, Biggs DF, Peterson MA (1979) Pharmacology of anatoxin-a produced by the freshwater cyanophyte Anabaena flos-aquae NRC-44-1. Toxicon 17: 229-236.

    Article  PubMed  CAS  Google Scholar 

  • Cianca RC, Pallares MA, Barbosa RD, Adan LV, Martins JM, Gago-Martinez A (2007) Application of precolumn oxidation HPLC method with fluorescence detection to evaluate saxitoxin levels in discrete brain regions of rats. Toxicon 49(1): 89-99.

    Article  CAS  Google Scholar 

  • Codd GA, Edwards C, Beattie KA, Barr WM, Gunn GJ (1992) Fatal attraction to cyanobacteria? Nature 359: 110-111.

    Article  PubMed  CAS  Google Scholar 

  • Codd GA, Metcalf JS, Beattie KA (1999) Retention of Microcystis aeruginosa and microcystin by salad lettuce (Lactuca sativa) after spray irrigation with water containing cyanobacteria. Toxicon. 37: 1181-1185.

    Article  PubMed  CAS  Google Scholar 

  • Cox PA, Sacks OW (2002) Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. Neurology 58: 956-959.

    PubMed  Google Scholar 

  • Craig M, Luu HA, McCready TL, Williams D, Andersen RJ, Holmes CFB (1996) Molecular mechanisms underlying the interaction of motuporin and microycystins with type-1 and type-2a protein phosphatases. Biochemistry & Cell Biology 74: 569-578.

    CAS  Google Scholar 

  • Dahlem AM, Hassan AS, Swanson SP, Carmichael WW, Beasley VR. (1989) A model system for studying the bioavailability of intestinally administered microcystin-LR, a hepatotoxic peptide from the cyanobacterium Microcystis aeruginosa. Pharmacol Toxicol. 64(2):177-81.

    PubMed  CAS  Google Scholar 

  • Dill K, Montgomery DD, Wang W, Tsai JC (2001) Antigen detection using microelectrode array microchips. Analytica Chimica Acta 444: 69-78.

    Article  CAS  Google Scholar 

  • Ding, WX, Shen, HM, and Ong, CN (2000) Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes. Hepatology 32: 547-555.

    Article  PubMed  CAS  Google Scholar 

  • Duncan MW, Markey SP, Weick BG, Pearson PG, Ziffer H, Hu Y, and Kopin IJ (1992) 2-Amino-3-(methylamino)propanoic acid (BMAA) bioavailability in the primate. Neurobiol Aging 13: 333-337.

    Article  PubMed  CAS  Google Scholar 

  • Duncan MW, Villacreses NE, Pearson PG, Wyatt L, Rapoport SI, Kopin IJ et al. (1991) 2-amino-3-(methylamino)-propanoic acid (BMAA) pharmacokinetics and blood-brain barrier permeability in the rat. J Pharmacol Exp Ther 258: 27-35.

    PubMed  CAS  Google Scholar 

  • Elleman TC, Falconer IR, Jackson AR, Runnegar MT (1978) Isolation, characterization and pathology of the toxin from a Microcystis aeruginosa (= Anacystis cyanea) bloom. Aust J Biol Sci 31(3): 209-18.

    PubMed  CAS  Google Scholar 

  • Edwards C, Beattie KA, Scrimgeour CM, Codd GA (1992) Identification of anatoxin-a in benthic cyanobacteria (blue-green algae) and in associated dog poisonings at Loch Insh, Scotland. Toxicon 30: 1165-1175.

    Article  PubMed  CAS  Google Scholar 

  • Falconer IR, Buckley T, Runnegar MT (1986) Biological half-life, organ distribution and excretion of 125-I-labelled toxic peptide from the blue-green alga Microcystis aeruginosa. Aust J Biol Sci 39: 17-21.

    PubMed  CAS  Google Scholar 

  • Falconer IR, Smith JV, Jackson AR, Jones A, Runnegar MT. (1988) Oral toxicity of a bloom of the Cyanobacterium microcystis Aeruginosa administered to mice over periods up to 1 year. J Toxicol Environ Health 24(3): 291-305.

    Article  PubMed  CAS  Google Scholar 

  • Falconer IR, Yeung DSK (1992) Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins. Chem-Biol-Interact 81: 181-196.

    Article  PubMed  CAS  Google Scholar 

  • Falconer IR, Burch MD, Steffensen DA, Choice M, Coverdale OR (1994) Toxicity of the blue-green alga (cyanobacterium) Microcystis aeruginosain drinking water to growing pigs, as an animal model for human injury and risk assessment. Env Toxicol Water Qual 9:131-139.

    Article  CAS  Google Scholar 

  • Falconer IR, Humpage AR (2001) Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga Cylindrospermopsis raciborskii containing the toxin cylindrospermopsin. Environ Toxicol 16: 192-195.

    Article  PubMed  CAS  Google Scholar 

  • Falconer IR, Hardy SJ, Humpage AR, Froscio SM, Tozer GJ, Hawkins PR (1999) Hepatic and renal toxicity of the blue-green alga (cyanobacterium) Cylindrospermopsis raciborskii in male Swiss Albino mice. Environmental Toxicology 14: 143-150.

    Article  CAS  Google Scholar 

  • Fawell JK, Mitchell RE, Everett DJ, Hill RE (1999) The toxicity of cyanobacterial toxins in the mouse: I microcystin-LR. Hum Exp Toxicol 18(3): 162-7.

    Article  PubMed  CAS  Google Scholar 

  • Fergusson KM, Saint CP (2003) Multiplex PCR assay for Cylindrospermopsis raciborskii and cylindrospermopsin-producing cyanobacteria. Environ Toxicol 18(2):120-125.

    Article  PubMed  CAS  Google Scholar 

  • Fessard V, Bernard C (2003) Cell alterations but no DNA strand breaks induced in vitro by cylindrospermopsin in CHO K1 cells. Environ Toxicol 18(5): 353-9.

    Article  PubMed  CAS  Google Scholar 

  • Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B (2005) Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin. Toxicol Appl Pharmacol. 203(3):257-63.

    Article  PubMed  CAS  Google Scholar 

  • Fischer WJ, Hitzfeld BC, Tencalla F, Eriksson JE, Mikhailov A, Dietrich DR. (2000) Microcystin-LR toxicodynamics, induced pathology, and immunohistochemical localization in livers of blue-green algae exposed rainbow trout (oncorhynchus mykiss). Toxicol Sci 54(2): 365-73.

    Article  PubMed  CAS  Google Scholar 

  • Fladmark, KE, Brustugun, OT, Boe, R, Vintermyr, OK, Howland, R, Gjertsen, BT (1999) Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors. Cell Death and Differentiation 6: 1099-1108.

    Article  PubMed  CAS  Google Scholar 

  • Fleming LE, Rivero C, Burns J, Williams C. Bean JA, Shea KA, Stinn J (2002) Blue-green algal (cyanobacterial) toxins, surface drinking water, and liver cancer in Florida. Harmful Algae 1: 157-168.

    Article  CAS  Google Scholar 

  • Froscio SM, Humpage AR, Burcham PC, Falconer, IR (2001) Cell-free protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin. Environ Toxicol 16: 408-412.

    Article  PubMed  CAS  Google Scholar 

  • Froscio SM, Humpage AR, Burcham PC, Falconer IR (2003) Cylindrospermopsin-induced protein synthesis inhibition and its dissociation from acute toxicity in mouse hepatocytes. Environmental Toxicology 18: 243-251.

    Article  PubMed  CAS  Google Scholar 

  • Fujiki H, Suganuma M (1993) Tumor promotion by inhibitors of protein phosphatases 1 and 2A: The okadaic acid class of compounds. Advances in Cancer Research 61: 143-194.

    PubMed  CAS  Google Scholar 

  • Furey A, Crowley J, Hamilton B, Lehane M, James KJ (2005) Strategies to avoid the mis-identification of anatoxin-a using mass spectrometry in the forensic investigation of acute neurotoxic poisoning. J Chromatogr A 1082: 91-97.

    Article  PubMed  CAS  Google Scholar 

  • Gago-Martinez A, Moscoso SA, Leao Martins JM, Rodriguez Vazquez JA, Niedzwiadek B, Lawrence JF. (2001) Effect of pH on the oxidation of paralytic shellfish poisoning toxins for analysis by liquid chromatography. J Chromatogr A. 905(1-2):351-7.

    Article  PubMed  CAS  Google Scholar 

  • Gehringer MM (2004) Microcystin-LR and okadaic acid-induced cellular effects: a dualistic response. FEBS Lett 557(1-3): 1-8.

    Article  PubMed  CAS  Google Scholar 

  • Gessner BD, Bell P, Doucette GJ, Moczydlowski E, Poli MA, Van Dolah F, Hall S. (1997) Hypertension and identification of toxin in human urine and serum following a cluster of mussel-associated paralytic shellfish poisoning outbreaks. Toxicon 35(5): 711-22.

    Article  PubMed  CAS  Google Scholar 

  • Ghazarossian VE, Schantz EJ, Schnoes HK, Strong FM (1976) A biologically active acid hydrolysis product of saxitoxin. Biochem Biophys Res Commun. 68(3):776-80.

    Article  PubMed  CAS  Google Scholar 

  • Goldberg J, Huang H, Kwon Y, Greengard P, Nairn AC, Kuriyan, J (1995) Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature 376: 745-753.

    Article  PubMed  CAS  Google Scholar 

  • Grosse Y, Baan R, Straif K, Secretan B, El Ghissassi F, Cogliano V, Cantor KP, Falconer IR, Levallois P, Verger P, Chorus I, Fujiki H, Ohshima H, Shibutani M, Lankoff A, Agudo A, Chan PC, Fan A, Karagas M, Mirvish S, Searles Nielsen S, Runnegar M, Ward MH, Wishnok J, Dietrich D, Junghans T, De Rosa C (2006) Carcinogenicity of nitrate, nitrite, and cyanobacterial peptide toxins. Lancet Oncology 7: 628-629.

    Article  PubMed  Google Scholar 

  • Gubbins MJ, Eddy FB, Gallacher S, Stagg RM (2000) Paralytic shellfish poisoning toxins induce xenobiotic metabolising enzymes in Atlantic salmon (Salmo salar). Mar Environ Res 50(1-5): 479-83.

    Article  PubMed  CAS  Google Scholar 

  • Guzman RE, Solter PF (1999) Hepatic oxidative stress following prolonged sublethal microcystin LR exposure. Toxicol Pathol 27(5): 582-8.

    Article  PubMed  CAS  Google Scholar 

  • Guzman RE, Solter PF, Runnegar MT (2003) Inhibition of nuclear protein phosphatase activity in mouse hepatocytes by the cyanobacterial toxin microcystin-LR. Toxicon 41(7): 773-81.

    Article  PubMed  CAS  Google Scholar 

  • Hall S, Reichardt, PB (1984) Cryptic paralytic shellfish toxins. In E. P. Ragelis (Ed) Seafood Toxins, pp. 113-124. Washington, DC: American Chemical Society.

    Google Scholar 

  • Hamm-Alvarez SF, Wei X, Berndt N, Runnegar M (1996) Protein phosphatases independently regulate vesicle movement and microtubule subpopulations in hepatocytes. Am J Physiol 271(3 Pt 1): C929-43.

    PubMed  CAS  Google Scholar 

  • HARRNESS (2005) Harmful Algal Research and Response: A National Environmental Science Strategy 2005-2015. Ramsdell, J. S., D. M. Anderson, and P. M. Glibert (Eds.), Ecological Society of America, Washington, DC, 96 pp.

    Google Scholar 

  • Hashmi M, and Anders MW (1991) Enzymatic reaction of beta-N-methylaminoalanine with L-amino acid oxidase. Biochim Biophys Acta 1074: 36-39.

    PubMed  CAS  Google Scholar 

  • Hawkins PR, Runnegar MTC, Jackson ARB, Falconer IR (1985) Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated form a domestic supply reservoir. Applied and Environmental Microbiology 50: 1292-1295.

    PubMed  CAS  Google Scholar 

  • Hilborn ED, Carmichael WW, Yuan M, Azevedo SMFO (2005) A simple colorimetric method to detect biological evidence of human exposure to microcystins. Toxicon 46: 218-221.

    Article  PubMed  CAS  Google Scholar 

  • Hines HB, Naseem SM, Wannemacher RW Jr. (1993) [3H]-saxitoxinol metabolism and elimination in the rat. Toxicon 31(7): 905-8.

    Article  PubMed  CAS  Google Scholar 

  • Hisbergues M, Christiansen G, Rouhiainen L, Sivonen K, Borner T. (2003) PCR-based identification of microcystin-producing genotypes of different cyanobacterial genera. Arch Microbiol. 180(6):402-10.

    Article  PubMed  CAS  Google Scholar 

  • Honkanen RE, Dukelow M, Zwiller J, Moore RE, Khatra BS, Boynton AL (1991) Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2a protein phosphatases. Molec. Pharmacol. 40: 577-583.

    CAS  Google Scholar 

  • Honkanen RE, Zwiller J, Moore RE, Daily SL, Khatra BS, Dukelow M, Boynton, AL (1990) Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2a protein phosphatases. J-Biol-Chem 265: 19401-19404.

    PubMed  CAS  Google Scholar 

  • Hooser, SB (2000) Fulminant hepatocyte apoptosis in vivo following microcystin-LR administration to rats. Toxicol Pathol 28: 726-733.

    Article  PubMed  CAS  Google Scholar 

  • Huby NJS, Thompson P, Wonnacott S, Gallagher T (1991) Structural modification of anatoxin-a. Synthesis of model affinity ligands for the nicotinic acetylcholine receptor. Journal of the Chemical Society, Chemical Communications 4: 243-245.

    Article  Google Scholar 

  • Humpage AR (this volume) Toxin types, toxicokinetics and toxicodynamics.

    Google Scholar 

  • Humpage AR, Falconer IR (1999) Microcystin-LR and liver tumour promotion: Effects on cytokinesis, ploidy and apoptosis in cultured hepatocytes. Environmental Toxicology 14: 61-75.

    Article  CAS  Google Scholar 

  • Humpage AR, Falconer IR (2003) Oral toxicity of the cyanobacterial toxin cylindrospermopsin in male Swiss albino mice: Determination of no observed adverse effect level for deriving a drinking water guideline value. Environ Toxicol 18: 94-103.

    Article  PubMed  CAS  Google Scholar 

  • Humpage AR, Fenech M, Thomas P, Falconer IR (2000a) Micronucleus induction and chromosome loss in transformed human white cells indicate clastogenic and aneugenic action of the cyanobacterial toxin, cylindrospermopsin. Mutat Res 472: 155-161.

    CAS  Google Scholar 

  • Humpage AR, Hardy SJ, Moore EJ, Froscio SM, Falconer IR (2000b) Microcystins (cyanobacterial toxins) in drinking water enhance the growth of aberrant crypt foci in the mouse colon. Journal of Toxicology & Environmental Health. Part A 61: 155-165.

    CAS  Google Scholar 

  • Humpage AR, Fontaine F, Froscio S, Burcham P, and Falconer IR (2005) Cylindrospermopsin genotoxicity and cytotoxicity: Role of cytochrome P-450 and oxidative stress. Journal of Toxicology and Environmental Health-Part a-Current Issues 68: 739-753.

    Article  CAS  Google Scholar 

  • Hyde EG, Carmichael WW (1991) Anatoxin-a(s), a naturally occurring organophosphate, is an irreversible active site-directed inhibitor of acetylcholinesterase (EC 3.1.1.7). Journal of Biochemical Toxicology 6, 3: 195-201.

    Article  Google Scholar 

  • Indrasena WM, Gill TA (1999) Thermal degradation of paralytic shellfish poisoning toxins in scallop digestive glands. Food Research International 32: 49-57.

    Article  CAS  Google Scholar 

  • Indrasena WM, Gill TA (2000) Storage stability of paralytic shellfish poisoning toxins. Food Chemistry 71: 71-77.

    Article  CAS  Google Scholar 

  • Ito E, Takai A, Kondo F, Masui H, Imanishi S, Harada K (2002) Comparison of protein phosphatase inhibitory activity and apparent toxicity of microcystins and related compounds. Toxicon. 40(7):1017-25.

    Article  PubMed  CAS  Google Scholar 

  • Ito E, Kondo F, Harada K (2001) Intratracheal administration of microcystin-LR, and its distribution. Toxicon 39(2-3):265-71.

    Article  PubMed  CAS  Google Scholar 

  • Ito E, Kondo F, Harada K (2000) First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method. Toxicon 38(1): 37-48.

    Article  PubMed  CAS  Google Scholar 

  • Ito E, Kondo F, Terao K, Harada KI (1997a) Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR. Toxicon 35: 1453-1457.

    Article  CAS  Google Scholar 

  • Ito E, Kondo F, Harada K (1997b) Hepatic necrosis in aged mice by oral administration of microcystin-LR. Toxicon. 1997 Feb;35(2):231-9.

    Google Scholar 

  • Jalaludin B, and Smith W (1992) Blue-green algae (cyanobacteria). Medical Journal of Australia 156: 744.

    PubMed  CAS  Google Scholar 

  • Jörvenpöö S-, Lundberg-Niinistö C, Spoof L, Sjövall O, Tyystjörvi E, Meriluoto J (2007) Effects of microcystins on broccoli and mustard, and analysis of accumulated toxin by liquid chromatography-mass spectrometry. Toxicon (in press).

    Google Scholar 

  • Jochimsen EM, Carmichael WW, An JS, Cardo DM, Cookson ST, Holmes CE, Antunes MB, de Melo Filho DA, Lyra TM, Barreto VS, Azevedo SM, Jarvis WR (1998) Liver failure and death after exposure to microcystins at a hemodialysis center in Brazil. N Engl J Med 338: 873-876.

    Article  PubMed  CAS  Google Scholar 

  • Karlsson K, Sipiö V, Krause E, Meriluoto J, Pflugmacher S (2003) Mass spectrometric detection and quantification of nodularin-R in flounder livers. Environ Tox 18: 284-288.

    Article  CAS  Google Scholar 

  • Kearns KD, Hunter MD (2000) Green algal extracellular products regulate antialgal toxin production in a cyanobacterium. Environ Microbiol. 2(3):291-7.

    Article  PubMed  CAS  Google Scholar 

  • Kondo F, Ikai Y, Oka H, Okumura M, Ishikawa N, Harada K, Matsuura K, Murata H, Suzuki M (1992) Formation, characterization, and toxicity of the glutathione and cysteine conjugates of toxic heptapeptide microcystins. Chem Res Toxicol. 5(5):591-6.

    Article  PubMed  CAS  Google Scholar 

  • Kondo F, Matsumoto H, Yamada S, Ishikawa N, Ito E, Nagata S (1996) Detection and identification of metabolites of microcystins formed in vivo in mouse and rat livers. Chem-Res-Toxicol 9: 1355-1359. N Engl J Med 338(13): 873-8. Erratum in: N Engl J Med 339(2): 139.

    Article  PubMed  CAS  Google Scholar 

  • Kuiper-Goodman T, Falconer I, Fitzgerald J (1999) Human health aspects. In Toxic Cyanobacteria In Water. A Guide To Their Public Health Consequences, Monitoring and Management. Chorus, I., and Bartram, J. (eds). London: E & FN Spon on behalf of WHO, pp. 113-153.

    Google Scholar 

  • Lanaras T, Cook CM, Eriksson J, Meriluoto J, Hotokka, M (1991) Computer modelling of the 3-dimensional structures of the cyanobacterial hepatotoxins microcystin-LR and nodularin. Toxicon 29, 7: 901-906.

    Article  Google Scholar 

  • Lankoff A, Banasik A, Deperas M, Kuźminski K, TarczyÅ„ska M, Jurczak T, Wojcik A (2003). Effect of microcystin - LR on cell cycle progression, mitotic spindle and apoptosis in CHO-K1 cells. Toxicol Applied Pharmacol 189: 204-213.

    Article  CAS  Google Scholar 

  • Lankoff A, Krzowski L, Glab J, Banasik A, Lisowska H, Kuszewski T, Gozdz S, and Wojcik A (2004). DNA damage and repair in human peripheral blood lymphocytes following treatment with microcystin-LR. Mutation Res. 559: 131-142.

    PubMed  CAS  Google Scholar 

  • Lankoff A, Bialczyk J, Dziga D, Carmichael WW, Lisowska H, Wojcik A (2006a). Inhibition of nucleotide excision repair (NER) by the PP1 and PP2A inhibitor-microcystin-LR in UV-irradiated CHO-K1 cells. Toxicon, 48: 957-965.

    Article  CAS  Google Scholar 

  • Lankoff A, Bialczyk J, Dziga D, W. Carmichael WW, Gradzka I, Lisowska H, Kuszewski T, Gozdz S, Piorun I, Wojcik A (2006b) The repair of gamma-radiation-induced DNA damage is inhibited by microcystin-LR, the PP1 and PP2A phosphatase inhibitor Mutagenesis 21: 83-90.

    CAS  Google Scholar 

  • Lawrence JF, Maher M, Watson-Wright W (1994) Effect of cooking on the concentration of toxins associated with paralytic shellfish poison in lobster hepatopancreas. Toxicon. 32(1):57-64.

    Article  PubMed  CAS  Google Scholar 

  • Laycock MV, Kralovec J, Richards R (1995) Some in vitro chemical conversions of paralytic shellfish poisoning (PSP) toxins useful in the preparation of analytical standards. J. Mar. Biotech. 3: 121-125.

    CAS  Google Scholar 

  • Lefebvre KA (2002) Sublethal effects of saxitoxin on early development and behavioral performance in fish. In Xth International Conference on Harmful Algae. St. Pete Beach, Florida, US.

    Google Scholar 

  • Lefebvre KA, Trainer VL, Scholz NL (2004) Morphological abnormalities and sensorimotor deficits in larval fish exposed to dissolved saxitoxin. Aquat Toxicol 66(2): 159-70.

    Article  PubMed  CAS  Google Scholar 

  • Liu BH, Yu FY, Huang X, Chu FS (2000) Monitoring of microcystin-protein phosphatase adduct formation with immunochemical methods. Toxicon. 38:619-32.

    Article  PubMed  CAS  Google Scholar 

  • Llewellyn LE, Dodd MJ, Robertson A, Ericson G, do Koning C, and Negri AP (2002) Post-mortem analysis of samples from a human victim of a fatal poisoning caused by the xanthid crab, Zosimus aeneus. Toxicon 40(10): 1463-1469.

    Article  PubMed  CAS  Google Scholar 

  • Llewellyn L, Negri A, Quilliam M (2004) High affinity for the rat brain sodium channel of newly discovered hydroxybenzoate saxitoxin analogues from the dinoflagellate Gymnodinium catenatum. Toxicon 43 (1): 101-4.

    Article  PubMed  CAS  Google Scholar 

  • Looper RE, Runnegar MTC, Williams, RM (2005) Synthesis of the putative structure of 7-deoxycylindrospermopsin: C7 oxygenation is not required for the inhibition of protein synthesis. Angewandte Chemie-International Edition 44: 3879-3881.

    Article  CAS  Google Scholar 

  • Love AH (this volume) Determining important parameters related to cyanobacterial alkaloid toxin exposure.

    Google Scholar 

  • MacKintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS-Lett 264: 187-192.

    Article  PubMed  CAS  Google Scholar 

  • Mahmood NA, Carmichael WW (1986) The pharmacology of anatoxin-a(s), a neurotoxin produced by the freshwater cyanobacterium Anabaena flos-aquae NRC 525-17. Toxicon 24, 5: 425-434.

    Article  PubMed  CAS  Google Scholar 

  • Mahmood NA, Carmichael WW (1987) Anatoxin-a(s), an anticholinesterase from the cyanobacterium Anabaena flos-aquae NRC-525-17. Toxicon 25: 1221-1227.

    Article  PubMed  CAS  Google Scholar 

  • Matsunaga S, Moore RE, Niemczura WP, Carmichael WW (1989) Anatoxin-a(s), a potent anticholinesterase from Anabaena flos-aquae. J Amer Chem Society 111: 8021-8023.

    Article  CAS  Google Scholar 

  • Metcalf JS, Beattie KA, Ressler J, Gerbersdorf S, Pflugmacher S, Codd GA (2002) Cross-reactivity and performance assessment of four microcystin immunoassays with detoxication products of the cyanobacterial toxin, microcystin-LR. J Water Supply Res Technol-Aqua 51: 145-151.

    CAS  Google Scholar 

  • Metcalf JS, Meriluoto JA and Codd GA (2006) Legal and security requirements for the air transportation of cyanotoxins and toxigenic cyanobacterial cells for legitimate research and analytical purposes. Toxicol Lett. 163:85-90.

    Article  PubMed  CAS  Google Scholar 

  • Meriluoto, J and Codd GA, eds. (2005) Toxic Cyanobacterial Monitoring and Cyanobacterial Analysis. Abo , Finland : Abo Akademi University Press.

    Google Scholar 

  • Meriluoto JA, Nygard SE, Dahlem AM, Eriksson JE (1990) Synthesis, organotropism and hepatocellular uptake of two tritium-labeled epimers of dihydromicrocystin-LR, a cyanobacterial peptide toxin analog. Toxicon 28(12): 1439-46

    Google Scholar 

  • Miura GA, Robinson NA, Lawrence WB, Pace JG (1991) Hepatotoxicity of microcystin-LR in fed and fasted rats. Toxicon 29(3): 337-46.

    Article  PubMed  CAS  Google Scholar 

  • Moore RE. (1996) Cyclic Peptides and depsipeptides from cyanobacteria: a review. J Industrial Microbiol Biotechnol 16(2):134-143.

    Article  CAS  Google Scholar 

  • Naseem SM (1996) Toxicokinetics of [3H]saxitoxinol in peripheral and central nervous system of rats. Toxicol Appl Pharmacol 141(1): 49-58.

    PubMed  CAS  Google Scholar 

  • Neilan BA (this volume) The genetics and genomics of cyanobacterial toxicity.

    Google Scholar 

  • Norris RL, Seawright AA, Shaw GR, Smith MJ, Chiswell RK, and Moore MR (2001) Distribution of 14C cylindrospermopsin in vivo in the mouse. Environ Toxicol 16: 498-505.

    Article  PubMed  CAS  Google Scholar 

  • Norris RL, Seawright AA, Shaw GR, Senogles P, Eaglesham GK, Smith MJ, Chiswell RK, Moore MR. (2002) Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse. Toxicon. 40(4):471-6.

    Article  PubMed  CAS  Google Scholar 

  • Ohta T, Sueoka E, Iida N, Komori A, Suganuma M, Nishiwaki R (1994) Nodularin, a potent inhibitor of protein phosphatases 1 and 2A, is a new environmental carcinogen in male F344 rat liver. Cancer Res 54: 6402-6406.

    PubMed  CAS  Google Scholar 

  • Ohtani I, Moore RE, Runnegar MTC (1992) Cylindrospermopsin: A potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii. J Amer Chem Society 114: 7941-7942.

    Article  CAS  Google Scholar 

  • Orr PT, Jones GJ, Hamilton GR (2004) Removal of saxitoxins from drinking water by granular activated carbon, ozone and hydrogen peroxide–implications for compliance with the Australian drinking water guidelines. Water Res. 38(20):4455-61.

    Article  PubMed  CAS  Google Scholar 

  • Oshima Y (1995) Postcolumn derivatization liquid chromatographic method for paralytic shellfish toxins. Journal of AOAC International 78: 528-532.

    CAS  Google Scholar 

  • Paul VJ, Cruz-Rivera E, and Thacker RW (2001) Chemical mediation of macroalgal-herbivore interactions: ecological and evolutionary perspectives. In: Marine Chemical Ecology, McClintock JB & Baker BJ, eds., pp. 227-265.

    Google Scholar 

  • Peuthert A, Chakrabarti S, Pflugmacher S (2007) Uptake of microcystins-LR and –LF (cyanobacterial toxins) in seedlings of several important agricultural plant species and the correlation with cellular damage (lipid peroxidation). Environmental Toxicology (in press)

    Google Scholar 

  • Pietsch C, Wiegand C, Ame MV, Nicklisch A, Wunderlin D, Pflugmacher S (2001) The effects of a cyanobacterial crude extract on different aquatic organisms: Evidence for cyanobacterial toxin modulating factors. Environ Tox 16: 535-542.

    Article  CAS  Google Scholar 

  • Pflugmacher S, Wiegand C, Oberemm A, Beattie KA, Krause E, Codd GA, Steinberg CE (1998) Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication. Biochim Biophys Acta 1425(3): 527-33.

    PubMed  CAS  Google Scholar 

  • Pflugmacher, S (2002) Possible allelopathic effects of cyanotoxins, with reference to microcystin-LR, in aquatic ecosystems. Environ Tox 17: 407-413.

    Article  CAS  Google Scholar 

  • Pflugmacher S, Wiegand C, Beattie KA, Krause E, Steinberg CEW, Codd GA (2001) Uptake, effects, and metabolism of cyanobacterial toxins in the emergent reed plant Phragmites australis (cav.) trin. ex steud. Environ Toxicol Chem 20: 846-852.

    Article  PubMed  CAS  Google Scholar 

  • Pflugmacher S, Jung K, Lundvall L, Neumann S, Peuthert A (2006) Effects of cyanobacterial toxins and cyanobacterial cell-free crude extract on germination of Alfalfa (Medicago sativa) and induction of oxidative stress. Environ Toxicol Chem 25: 2381-2387.

    Article  PubMed  CAS  Google Scholar 

  • Pomati F, Manarolla G, Rossi O, Vigetti D, Rossetti C (2001) The purine degradation pathway: possible role in paralytic shellfish toxin metabolism in the cyanobacterium Planktothrix sp. FP1. Environ Int. 27(6):463-70.

    Google Scholar 

  • Pomati F, Moffitt MC, Cavaliere R, Neilan BA (2004) Evidence for differences in the metabolism of saxitoxin and C1+2 toxins in the freshwater cyanobacterium Cylindrospermopsis raciborskii T3. Biochim Biophys Acta. 1674(1): 60-7.

    PubMed  CAS  Google Scholar 

  • Pouria S, de Andrade A, Barbosa J, Cavalcanti RL, Barreto VT, Ward CJ, Preiser W, Poon GK, Neild GH, Codd GA. (1998) Fatal microcystin intoxication in haemodialysis unit in Caruaru, Brazil. Lancet 352(9121): 21-6.

    Article  PubMed  CAS  Google Scholar 

  • Rinehart KL, Namikoshi M (1994) Structure and biosynthesis of toxins from blue-green algae (cyanobacteria). Journal of Applied Phycology 6: 159-176.

    Article  CAS  Google Scholar 

  • Rinehart KL, Harada K, Namikoshi M, Chen C, Harvis CA (1988) Nodularin, microcystin and the configuration of ADDA. Journal of the American Chemical Society 110: 8557-8558.

    Article  CAS  Google Scholar 

  • Robinson NA, Miura GA, Matson CF, Dinterman RE, and Pace JG (1989) Characterization of chemically tritiated microcystin-LR and its distribution in mice. Toxicon 27: 1035-1042.

    Article  PubMed  CAS  Google Scholar 

  • Robinson NA, Pace JG, Matson CF, Miura, GA, Lawrence WB (1991) Tissue distribution, excretion and hepatic biotransformation of microcystin-LR in mice. J Pharmacol Exp Ther 256: 176-182.

    PubMed  CAS  Google Scholar 

  • Runnegar MT, Falconer IR (1986) Effect of toxin from the cyanobacterium Microcystis aeruginosa on ultrastructural morphology and actin polymerization in isolated hepatocytes. Toxicon 24: 109-115.

    Article  PubMed  CAS  Google Scholar 

  • Runnegar MT, Kong S, and Berndt N (1993) Protein phosphatase inhibition and in vivo hepatotoxicity of microcystins. Am J Physiol 265: G224-230.

    PubMed  CAS  Google Scholar 

  • Runnegar MT, Falconer IR, Buckley T, and Jackson AR (1986) Lethal potency and tissue distribution of 125I-labelled toxic peptides from the blue-green alga Microcystis aeruginosa. Toxicon 24: 506-509.

    Article  PubMed  CAS  Google Scholar 

  • Runnegar MT, Maddatu T, Deleve LD, Berndt N, Govindarajan S (1995a) Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A. J Pharmacol Exp Ther. 273: 545-53.

    CAS  Google Scholar 

  • Runnegar MT, Kong SM, Zhong YZ, and Lu SC (1995b) Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem Pharmacol 49: 219-225.

    Article  CAS  Google Scholar 

  • Runnegar MT, Kong SM, Zhong YZ, Ge JL, and Lu SC (1994) The role of glutathione in the toxicity of a novel cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem Biophys Res Commun 201: 235-241.

    Article  PubMed  CAS  Google Scholar 

  • Runnegar M, Wei X, Berndt N, Hamm-Alvarez SF (1997) Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport. Hepatology 26(1): 176-85.

    Article  PubMed  CAS  Google Scholar 

  • Runnegar MT, Xie CY, Snider BB, Wallace, GA, Weinreb, SM, Kuhlenkamp J (2002) In vitro hepatotoxicity of the cyanobacterial alkaloid cylindrospermopsin and related synthetic analogues. Toxicological Sciences 67: 81-87.

    Article  PubMed  CAS  Google Scholar 

  • Seawright AA, Brown AW, Nolan CC, and Cavanagh JB (1990) Selective degeneration of cerebellar cortical neurons caused by cycad neurotoxin, L-beta-methylaminoalanine (L-BMAA), in rats. Neuropathol Appl Neurobiol 16: 153-169.

    PubMed  CAS  Google Scholar 

  • Seawright AA, Nolan CC, Shaw GR, Chiswell RK, Norris RL, Moore MR, Smith MJ (1999) The oral toxicity for mice of the tropical cyanobacterium Cylindrospermopsis raciborskii (Woloszynska). Environmental Toxicology 14: 135-142.

    Article  CAS  Google Scholar 

  • Senogles-Derham PJ, Seawright A, Shaw G, Wickramisingh W, Shahin M (2003) Toxicological aspects of treatment to remove cyanobacterial toxins from drinking water determined using the heterozygous P53 transgenic mouse model. Toxicon. 41(8):979-88.

    Article  PubMed  CAS  Google Scholar 

  • Shaw GR, Seawright AA, Moore MR, Lam PK (2000) Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity. Ther Drug Monit 22(1): 89-92.

    Article  PubMed  CAS  Google Scholar 

  • Shen XY, Lam PKS, Shaw GR, Wickramasinghe W (2002) Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin. Toxicon 40: 1499-1501.

    Article  PubMed  CAS  Google Scholar 

  • Sipia VO, Kankaanpaa HT, Pflugmacher S, Flinkman J, Furey A, James KJ (2002) Bioaccumulation and detoxication of nodularin in tissues of flounder (Platichthys flesus), mussels (Mytilus edulis, Dreissena polymorpha), and clams (Macoma balthica) from the northern Baltic Sea. Ecotoxicol Environ Saf 53(2): 305-11.

    Article  PubMed  CAS  Google Scholar 

  • Soares RM, Yuan M, Servaites JC, Delgado A, Magalhães VF, Hilborn ED, Carmichael WW,. Azevedo SMFO (2006) Sub-lethal exposure from microcystins to renal insufficiency patients in Rio de Janeiro – Brazil. Environ Toxicol. 21: 95-103.

    Article  PubMed  CAS  Google Scholar 

  • Solter PF, Wollenberg GK, Huang X, Chu FS, Runnegar MT (1998) Prolonged sublethal exposure to the protein phosphatase inhibitor microcystin-LR results in multiple dose-dependent hepatotoxic effects. Toxicol Sci 44(1): 87-96.

    Article  PubMed  CAS  Google Scholar 

  • Stotts RR, Twardock AR, Haschek WM, Choi BW, Rinehart KL, Beasley VR. (1997) Distribution of tritiated dihydromicrocystin in swine. Toxicon. 35(6): 937-53.

    Article  PubMed  CAS  Google Scholar 

  • Stotts RR, Twardock AR, Koritz GD, Haschek WM, Manuel RK, Hollis WB, Beasley VR. (1997) Toxicokinetics of tritiated dihydromicrocystin-LR in swine. Toxicon. 35(3):455-65.

    Article  PubMed  CAS  Google Scholar 

  • Sueoka E, Sueoka N, Okabe S, Kozu T, Komori A, Ohta T, Suganuma M, Kim SJ, Lim IK, Fujiki H (1997) Expression of the tumor necrosis factorαp; gene and early response genes by nodularin, a liver tumor promoter, in primary cultured rat hepatocytes. J Cancer Res and Clin Oncol 123: 413-419.

    CAS  Google Scholar 

  • Sullivan JJ, Iwaoka WT, Liston J (1983) Enzymatic transformation of PSP toxins in the littleneck clam (Protothaca staminea). Biochem Biophys Res Commun. 114(2):465-72.

    Article  PubMed  CAS  Google Scholar 

  • Swanson KL, Rapoport H, Albuquerque EX, Aronstam RS (1990) Nicotinic acetylcholine receptor function studied with synthetic (+)-anatoxin-a and derivatives. In Marine toxins. Origin, structure, and molecular pharmacology. Hall, S., and Strichartz, G. (eds). Washington, DC: American Chemical Society, pp. 107-118.

    Google Scholar 

  • Swanson KL, Aronstam RS, Wonnacott S, Rapoport H, Albuquerque EX (1991) Nicotinic pharmacology of anatoxin analogs. I. Side chain structure-activity relationships at peripheral agonist and noncompetitive antagonist sites. J Pharmacol Exp Ther 259: 377-386.

    PubMed  CAS  Google Scholar 

  • Takenaka S (2001) Covalent glutathione conjugation to cyanobacterial hepatotoxin microcystin LR by F344 rat cytosolic and microsomal glutathione S-transferases. Environ Toxicol Pharm 9(4):135-139.

    Article  CAS  Google Scholar 

  • Terao K, Ohmori S, Igarashi K, Ohtani I, Watanabe MF, Harada KI(1994) Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans. Toxicon 32: 833-843.

    Google Scholar 

  • Thacker RW, McLeod AM, McLeod SW (2005) Herbivore-induced saxitoxin production in the freshwater cyanobacterium Lyngbya wollei. Algological Studies 117: 415-425.

    Article  Google Scholar 

  • Trainer V, Baden DG (1999) High affinity binding of red tide neurotoxins to marine mammal brain. Aquatic Toxicology 46(2): 139-148.

    Article  CAS  Google Scholar 

  • Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe MF, Park HD, Chen GC, Chen G, Yu S-Z (1996) Detection of microcystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 17: 1317-1321.

    Article  PubMed  CAS  Google Scholar 

  • Ueno Y, Makita Y, Nagata S, Tsutsumi T, Yoshida F, Tamura S-I, Sekijima M, Tashiro F, Harada T, Yoshida T (1999) No chronic oral toxicity of a low dose of microcystin-LR, a cyanobacterial hepatotoxin, in female BALB/c mice. Environ Toxicol 14: 45-55.

    Article  CAS  Google Scholar 

  • Wiegand C, Pflugmacher S (2005) Ecotoxicological effects of selected cyanobacterial secondary metabolites: a short review. Toxicol Appl Pharmacol 203: 201-18.

    Article  PubMed  CAS  Google Scholar 

  • WHO, 1999). Toxic Cyanobacteria in Water: A guide to their public health consequences, monitoring and management. Chapter 13. Laboratory analysis of cyanotoxins.

    Google Scholar 

  • Wonnacott S, Jackman S, Swanson KL, Rapoport H, Albuquerque EX (1991) Nicotinic pharmacology of anatoxin analogs. II. Side chain structure-activity relationships at neuronal nicotinic ligand binding sites. J Pharmacol Exp Ther 259: 387-391.

    PubMed  CAS  Google Scholar 

  • Yin Q, Carmichael WW, Evans WR (1997) Factors influencing growth and toxin production by cultures of the freshwater cyanobacterium Lyngbya wollei Farlow ex Gomont. J. of Applied Phycology 9:55-63.

    Article  CAS  Google Scholar 

  • Yoshida T, Makita Y, Nagata S, Tsutsumi T, Yoshida F, Sekijima M, Tamura S, Ueno Y (1997) Acute oral toxicity of microcystin-LR, a cyanobacterial hepatotoxin, in mice. Nat Toxins 5(3): 91-5.

    Article  PubMed  CAS  Google Scholar 

  • Yoshida T, Makita Y, Tsutsumi T, Nagata S, Tashiro F, Yoshida F, Sekijima M, Tamura S, Harada T, Maita K, Ueno Y (1998) Immunohistochemical localization of microcystin-LR in the liver of mice: a study on the pathogenesis of microcystin-LR-induced hepatotoxicity. Toxicol Pathol 26(3): 411-8.

    Article  PubMed  CAS  Google Scholar 

  • Yu SZ (1995) Primary prevention of hepatocellular carcinoma. Journal of Gastroenterology and Hepatology 10: 674-682.

    Article  PubMed  CAS  Google Scholar 

  • Yuan M, Carmichael WW, Hilborn ED (2006) Microcystin analysis in human sera and liver from human fatalities in Caruaru, Brazil 1996. Toxicon 48: 627-640.

    Article  PubMed  CAS  Google Scholar 

  • Zhou L, Yu H, Chen K (2002) Relationship between microcystin in drinking water and colorectal cancer. Biomed-Environ-Sci 15: 166-171.

    Article  PubMed  Google Scholar 

  • Zhu Y, Zhong X, Zheng S, Ge Z, Du Q, Zhang S (2005) Transformation of immortalized colorectal crypt cells by microcystin involving constitutive activation of Akt and MAPK cascade. Carcinogenesis 26(7): 1207-14.

    Article  PubMed  CAS  Google Scholar 

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    Rex A Pegram & Tonya Nichols

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Pegram, R.A. et al. (2008). Cyanotoxins Workgroup Report. In: Hudnell, H.K. (eds) Cyanobacterial Harmful Algal Blooms: State of the Science and Research Needs. Advances in Experimental Medicine and Biology, vol 619. Springer, New York, NY. https://doi.org/10.1007/978-0-387-75865-7_15

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