The lipofuscin that accumulates in retinal pigment epithelial cells with age and that is abundant in some retinal disorders, is sequestered within the interior of membrane bound organelles of the lysosomal compartment of the cell. RPE lipofuscin pigments form in large part due to reactions of vitamin A aldehyde.
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Sparrow, J.R., Kim, S.R., Cuervo, A.M., Bandhyopadhyayand, U. (2008). A2E, A Pigment of RPE Lipofuscin, is Generated from the Precursor, A2PE by a Lysosomal Enzyme Activity. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Recent Advances in Retinal Degeneration. Advances in Experimental Medicine and Biology, vol 613. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74904-4_46
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