Guanylate cyclase 1 (GC1) is present in mouse rod and cone outer segments while guanylate cyclase 2 (GC2) is present only in rods. Accordingly, deletion of GC1 (gene symbol Gucy2e) affects predominantly cones while knockout of GC2 (gene symbol Gucy2f) has no major effect on rod and cone physiology since GC1 can substitute for the loss of GC2. Simultaneous inactivation of GC1 and GC2 abolishes rod and cone phototransduction, generating a phenotype affecting viability of both rods and cones, and resembling human Leber Congenital Amaurosis.
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Karan, S., Frederick, J.M., Baehr, W. (2008). Involvement of Guanylate Cyclases in Transport of Photoreceptor Peripheral Membrane Proteins. In: Anderson, R.E., LaVail, M.M., Hollyfield, J.G. (eds) Recent Advances in Retinal Degeneration. Advances in Experimental Medicine and Biology, vol 613. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74904-4_41
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