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Health-Promoting Effects of Wine Phenolics

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Wine Chemistry and Biochemistry

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References

  • Abu-Amsha Caccetta, R., Burke, V., Mori, T. A., Beilin, L. J., Puddey, I. B., & Croft, K. D. (2001). Red wine polyphenols, in the absence of alcohol, reduce lipid peroxidative stress in smoking subjects. Free Rad. Biol. Med., 30, 636–642.

    Article  CAS  Google Scholar 

  • Ader, P., Block, M., Pietzsch, S., & Wolffram, S. (2001). Interaction of quercetin glucosides with the intestinal sodium/glucose co-transporter (SGLT-1). Cancer Lett., 162, 175–180.

    Article  CAS  Google Scholar 

  • Al-Awwadi, N. A., Araiz, C., Bornet, A., Delbosc, S., Cristol, J. P., Linck, N., Azay, J., Teissedre, P. L., & Cros, G. (2005). Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats. J. Agric. Food Chem., 53, 151–157.

    Article  CAS  Google Scholar 

  • Allister, E. M., Borradaile, N. M., Edwards, J. Y., & Huff, M. W. (2005). Inhibition of microsomal triglyceride transfer protein expression and apolipoprotein B100 secretion by the citrus flavonoid naringenin and by insulin involves activation of the mitogen-activated protein kinase pathway in hepatocytes. Diabetes, 54, 1676–1683.

    Article  CAS  Google Scholar 

  • Anter, E., Thomas, S. R., Schulz, E., Shapira, O. M., Vita, J. A., & Keaney, J. F. Jr. (2004). Activation of endothelial nitric-oxide synthase by the p38 MAPK in response to black tea polyphenols. J. Biol. Chem., 279, 46637–46643.

    Article  CAS  Google Scholar 

  • Arts, I. C., & Hollman, P. C. (2005). Polyphenols and disease risk in epidemiologic studies. Am. J. Clin. Nutr., 81, 317S–325S.

    CAS  Google Scholar 

  • Avellone, G., Di Garbo, V., Campisi, D., De Simone, R., Raneli, G., Scaglione, R., & Licata, G. (2006). Effects of moderate Sicilian red wine consumption on inflammatory biomarkers of atherosclerosis. Eur. J. Clin. Nutr., 60, 41–47.

    Article  CAS  Google Scholar 

  • Aviram, M., & Fuhrman, B. (1998). Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis, 137, S45–S50.

    Article  CAS  Google Scholar 

  • Azumi, H., Inoue, N., Ohashi, Y., Terashima, M., Mori, T., Fujita, H., Awano, K., Kobayashi, K., Maeda, K., Hata, K., Shinke, T., Kobayashi, S., Hirata, K., Kawashima, S., Itabe, H., Hayashi, Y., Imajoh-Ohmi, S., Itoh, H., & Yokoyama, M. (2002). Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: important role of NAD(P)H oxidase. Arterioscler. Thromb. Vasc. Biol., 22, 1838–1844.

    Article  CAS  Google Scholar 

  • Baba, S., Natsume, M., Yasuda, A., Nakamura, Y., Tamura, T., Osakabe, N., Kanegae, M., & Kondo, K. (2007a). Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder. J. Nutr., 137, 1436–1441.

    CAS  Google Scholar 

  • Baba, S., Osakabe, N., Kato, Y., Natsume, M., Yasuda, A., Kido, T., Fukuda, K., Muto, Y., & Kondo, K. (2007b). Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. Am. J. Clin. Nutr., 85, 709–717.

    CAS  Google Scholar 

  • Baron-Menguy, C., Bocquet, A., Guihot, A. L., Chappard, D., Amiot, M. J., Andriantsitohaina, R., Loufrani, L., & Henrion, D. (2007). Effects of red wine polyphenols on postischemic neovascularization model in rats: low doses are proangiogenic, high doses anti-angiogenic. FASEB J., 13, 3511–3521.

    Article  CAS  Google Scholar 

  • Basak, S., Kim, H., Kearns, J. D., Tergaonkar, V., O’Dea, E., Werner, S. L., Benedict, C. A., Ware, C. F., Ghosh, G., Verma, I. M., & Hoffmann, A. (2007). A fourth IkappaB protein within the NF-kappaB signaling module. Cell, 128, 369–381.

    Article  CAS  Google Scholar 

  • Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., Pistell, P. J., Poosala, S., Becker, K. G., Boss, O., Gwinn, D., Wang, M., Ramaswamy, S., Fishbein, K. W., Spencer, R. G., Lakatta, E. G., Le Couteur, D., Shaw, R. J., Navas, P., Puigserver, P., Ingram, D. K., de Cabo, R., & Sinclair, D. A. (2006). Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444, 337–342.

    Article  CAS  Google Scholar 

  • Bedard, K., & Krause, K. H. (2007). The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol. Rev., 87, 245–313.

    Article  CAS  Google Scholar 

  • Bell, J. R., Donovan, J. L., Wong, R., Waterhouse, A. L., German, J. B., Walzem, R. L., & Kasim-Karakas, S. E. (2000). (+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine. Am. J. Clin. Nutr., 71, 103–108.

    CAS  Google Scholar 

  • Berge, K. E., Tian, H., Graf, G. A., Yu, L., Grishin, N. V., Schultz, J., Kwiterovich, P., Shan, B., Barnes, R., & Hobbs, H. H. (2000). Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science, 290, 1771–1775.

    Article  CAS  Google Scholar 

  • Bitsch, R., Netzel, M., Frank, T., Strass, G., & Bitsch, I. (2004). Bioavailability and Biokinetics of Anthocyanins From Red Grape Juice and Red Wine. J. Biomed. Biotechnol., 5, 293–298.

    Article  Google Scholar 

  • Blanco-Colio, L. M., Valderrama, M., Alvarez-Sala, L. A., Bustos, C., Ortego, M., Hernandez-Presa, M. A., Cancelas, P., Gomez-Gerique, J., Millan, J., & Egido, J. (2000). Red wine intake prevents nuclear factor-kappaB activation in peripheral blood mononuclear cells of healthy volunteers during postprandial lipemia. Circulation, 102, 1020–1026.

    CAS  Google Scholar 

  • Blanco-Colio, L. M., Muñoz-García, B., Martín-Ventura, J. L., Alvarez-Sala, L. A., Castilla, M., Bustamante, A., Lamuela-Raventós, R. M., Gómez-Gerique, J., Fernández-Cruz, A., Millán, J., & Egido, J. (2007). Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet. Atherosclerosis, 192, 335–341.

    Article  CAS  Google Scholar 

  • Borges, G., Roowi, S., Rouanet, J. M., Duthie, G. G., Lean, M. E., & Crozier, A. (2007). The bioavailability and absorption of anthocyanins: towards a better understanding. Mol. Nutr. Food Res., 51, 702–713.

    Article  CAS  Google Scholar 

  • Borradaile, N. M., de Dreu, L. E., Barrett, P. H., Behrsin, C. D., & Huff, M. W. (2003). Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry, 42, 1283–1291.

    Google Scholar 

  • Bourne, L., Paganga, G., Baxter, D., Hughes, P., & Rice-Evans, C. (2000). Absorption of ferulic acid from low-alcohol beer. Free Rad. Res., 32, 273–280.

    Article  CAS  Google Scholar 

  • Brown, M. S., Ye, J., Rawson, R. B., & Goldstein, J. L. (2000). Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans. Cell, 100, 391–398.

    Article  CAS  Google Scholar 

  • Bub, A., Watzl, B., Heeb, D., Rechkemmer, G., & Briviba, K. (2001). Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur. J. Nutr., 40, 113–120.

    Article  CAS  Google Scholar 

  • Bursill, C. A., & Roach, P. D. (2006). Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells. J. Agric. Food Chem., 54, 1621–1626.

    Article  CAS  Google Scholar 

  • Bursill, C. A., Abbey, M., & Roach, P. D. (2007). A green tea extract lowers plasma cholesterol by inhibiting cholesterol synthesis and upregulating the LDL receptor in the cholesterol-fed rabbit. Atherosclerosis, 193, 86–93.

    Google Scholar 

  • Caccetta, R. A., Croft, K. D., Beilin, L. J., & Puddey, I. B. (2000). Ingestion of red wine significantly increases plasma phenolic acid concentrations but does not acutely affect ex vivo lipoprotein oxidizability. Am. J. Clin. Nutr., 71, 67–74.

    CAS  Google Scholar 

  • Carnevale, R., Pignatelli, P., Lenti, L., Buchetti, B., Sanguigni, V., Di Santo, S., & Violi, F. (2007). LDL are oxidatively modified by platelets via GP91(phox) and accumulate in human monocytes. FASEB J., 21, 927–934.

    Article  CAS  Google Scholar 

  • Cartron, E., Fouret, G., Carbonneau, M. A., Lauret, C., Michel, F., Monnier, L., Descomps, B., & Leger, C. L. (2003). Red-wine beneficial long-term effect on lipids but not on antioxidant characteristics in plasma in a study comparing three types of wine–description of two O-methylated derivatives of gallic acid in humans. Free Rad. Res., 37, 1021–1035.

    Article  CAS  Google Scholar 

  • Casaschi, A., Wang, Q., Dang, K., Richards, A., & Theriault, A. (2002). Intestinal apolipoprotein B secretion is inhibited by the flavonoid quercetin: potential role of microsomal triglyceride transfer protein and diacylglycerol acyltransferase. Lipids, 37, 647–652.

    Article  CAS  Google Scholar 

  • Castilla, P., Echarri, R., Dávalos, A., Cerrato, F., Ortega, H., Teruel, J. L., Lucas, M. F., Gómez-Coronado, D., Ortuno, J., & Lasunción, M. A. (2006). Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am. J. Clin. Nutr., 84, 252–262.

    CAS  Google Scholar 

  • Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006). NADPH oxidases in cardiovascular health and disease. Antiox. Redox Signal., 8, 691–728.

    Article  CAS  Google Scholar 

  • Clee, S. M., Kastelein, J. J., van Dam, M., Marcil, M., Roomp, K., Zwarts, K. Y., Collins, J. A., Roelants, R., Tamasawa, N., Stulc, T., Suda, T., Ceska, R., Boucher, B., Rondeau, C., DeSouich, C., Brooks-Wilson, A., Molhuizen, H. O., Frohlich, J., Genest, J. Jr., & Hayden, M. R. (2000). Age and residual cholesterol efflux affect HDL cholesterol levels and coronary artery disease in ABCA1 heterozygotes. J. Clin. Inves., 106, 1263–1270.

    Article  CAS  Google Scholar 

  • Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004). Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science, 305, 390–392.

    Article  CAS  Google Scholar 

  • Corder, R., Douthwaite, J. A., Lees, D. M., Khan, N. Q., Viseu Dos Santos, A. C., Wood, E. G., & Carrier, M. J. (2001). Endothelin-1 synthesis reduced by red wine. Nature, 414, 863–864.

    Article  CAS  Google Scholar 

  • Corder, R., Mullen, W., Khan, N. Q., Marks, S. C., Wood, E. G., Carrier, M. J., & Crozier, A. (2006). Oenology: red wine procyanidins and vascular health. Nature, 444, 566.

    Article  CAS  Google Scholar 

  • Covas, M. I., Konstantinidou, V., Mysytaki, E., Fito, M., Weinbrenner, T., De La Torre, R., Farre-Albadalejo, M., & Lamuela-Raventos, R. (2003). Postprandial effects of wine consumption on lipids and oxidative stress biomarkers. Drugs Exp. Clin. Res., 29, 217–223.

    CAS  Google Scholar 

  • Covas, M. I., Nyyssonen, K., Poulsen, H. E., Kaikkonen, J., Zunft, H. J., Kiesewetter, H., Gaddi, A., de la Torre, R., Mursu, J., Baumler, H., Nascetti, S., Salonen, J. T., Fito, M., Virtanen, J., Marrugat, J., & EUROLIVE Study Group. (2006). The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann. Intern. Med., 145, 333–341.

    CAS  Google Scholar 

  • Dávalos, A., Fernández-Hernando, C., Cerrato, F., Martínez-Botas, J., Gómez-Coronado, D., Gómez-Cordoves, C., & Lasunción. M. A. (2006). Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. J. Nutr., 136, 1766–1773.

    Google Scholar 

  • Davis, J. N., Kucuk, O., Djuric, Z., & Sarkar, F. H. (2001). Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes. Free Rad. Biol. Med., 30, 1293–1302.

    Article  CAS  Google Scholar 

  • Day, A. J., Canada, F. J., Diaz, J. C., Kroon, P. A., Mclauchlan, R., Faulds, C. B., Plumb, G. W., Morgan, M. R., & Williamson, G. (2000). Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Letters, 468, 166–170.

    Article  CAS  Google Scholar 

  • De Boer, V. C., de Goffau, M. C., Arts, I. C., Hollman, P. C., & Keijer, J. (2006). SIRT1 stimulation by polyphenols is affected by their stability and metabolism. Mech. Ageing Dev., 127, 618–627.

    Article  CAS  Google Scholar 

  • De Graaf, M., van Veen, I. C., van der Meulen-Muileman, I. H., Gerritsen, W. R., Pinedo, H. M., & Haisma, H. J. (2001). Cloning and characterization of human liver cytosolic beta-glycosidase. Biochem. J., 356, 907–910.

    Article  Google Scholar 

  • De Vries, J. H., Hollman, P. C., van Amersfoort, I., Olthof, M. R., & Katan, M. B. (2001). Red wine is a poor source of bioavailable flavonols in men. J. Nutr., 131, 745–748.

    Google Scholar 

  • De Whalley, C. V., Rankin, S. M., Hoult, J. R., Jessup, W., & Leake, D. S. (1990). Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. Biochem. Pharmacol., 39, 1743–1750.

    Article  Google Scholar 

  • Deckert, V., Desrumaux, C., Athias, A., Duverneuil, L., Palleau, V., Gambert, P., Masson, D., & Lagrost, L. (2002). Prevention of LDL alpha-tocopherol consumption, cholesterol oxidation, and vascular endothelium dysfunction by polyphenolic compounds from red wine. Atherosclerosis, 165, 41–50.

    Article  CAS  Google Scholar 

  • Del Bas, J. M., Fernandez-Larrea, J., Blay, M., Ardevol, A., Salvado, M. J., Arola, L., & Blade, C. (2005). Grape seed procyanidins improve atherosclerotic risk index and induce liver CYP7A1 and SHP expression in healthy rats. FASEB J., 19, 479–481.

    CAS  Google Scholar 

  • Di Bari, M., Zacchei, S., Kritchevsky, S. B., Anichini, M., Cesaretti, S., Chiarlone, M., Masotti, G., & Marchionni, N. (2003). Anti-oxidized LDL antibodies and wine consumption: a population-based epidemiological study in Dicomano, Italy. Ann. Epidemiol., 13, 189–195.

    Article  Google Scholar 

  • Donovan, J. L., Bell, J. R., Kasim-Karakas, S., German, J. B., Walzem, R. L., Hansen, R. J., & Waterhouse, A. L. (1999). Catechin is present as metabolites in human plasma after consumption of red wine. J. Nutr., 129, 1662–1668.

    CAS  Google Scholar 

  • El Bedoui, J., Oak, M. H., Anglard, P., & Schini-Kerth, V. B. (2005). Catechins prevent vascular smooth muscle cell invasion by inhibiting MT1-MMP activity and MMP-2 expression. Cardiovasc. Res., 67, 317–325.

    Article  CAS  Google Scholar 

  • Estruch, R., Sacanella, E., Badia, E., Antunez, E., Nicolas, J. M., Fernandez-Sola, J., Rotilio, D., de Gaetano, G., Rubin, E., & Urbano-Marquez, A. (2004). Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers. Atherosclerosis, 175, 117–123.

    Article  CAS  Google Scholar 

  • Feng, B., Yao, P. M., Li, Y., Devlin, C. M., Zhang, D., Harding, H. P., Sweeney, M., Rong, J. X., Kuriakose, G., Fisher, E. A., Marks, A. R., Ron, D., & Tabas, I. (2003). The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat. Cell Biol., 5, 781–792.

    Article  CAS  Google Scholar 

  • Finkel, T., & Holbrook, N. J. (2000). Oxidants, oxidative stress and the biology of ageing. Nature, 408, 239–247.

    Article  CAS  Google Scholar 

  • Fontana, L., & Klein, S. (2007). Aging, adiposity, and calorie restriction. JAMA, 297, 986–994.

    Article  CAS  Google Scholar 

  • Fortuño, A., Beloqui, O., San Jose, G., Moreno, M. U., Zalba, G., & Diez, J. (2005). Increased phagocytic nicotinamide adenine dinucleotide phosphate oxidase-dependent superoxide production in patients with early chronic kidney disease. Kidney Inter. Suppl., 99, S71–S75.

    Article  Google Scholar 

  • Fortuño, A., San José, G., Moreno, M. U., Beloqui, O., Diez, J., & Zalba, G. (2006). Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome. Diabetes, 55, 209–215.

    Article  Google Scholar 

  • Frank, J., Budek, A., Lundh, T., Parker, R. S., Swanson, J. E., Lourenco, C. F., Gago, B., Laranjinha, J., Vessby, B., & Kamal-Eldin, A. (2006). Dietary flavonoids with a catechol structure increase alpha-tocopherol in rats and protect the vitamin from oxidation in vitro. J. Lipid Res., 47, 2718–2725.

    Article  CAS  Google Scholar 

  • Frank, T., Netzel, M., Strass, G., Bitsch, R., & Bitsch, I. (2003). Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice. Can. J. Physiol. Pharmacol., 81, 423–435.

    Article  CAS  Google Scholar 

  • Frankel, E. N., Kanner, J., German, J. B., Parks, E., & Kinsella, J. E. (1993). Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. The Lancet, 341, 454–457.

    Google Scholar 

  • Fuhrman, B., & Aviram, M. (2002). Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation. Ann. N.Y. Acad. Sci., 957, 321–324.

    CAS  Google Scholar 

  • Fuhrman, B., Lavy, A., & Aviram, M. (1995). Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. Am. J. Clin. Nutr., 61, 549–554.

    Google Scholar 

  • Garvin, S., Ollinger, K., & Dabrosin, C. (2006). Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett., 231, 113–122.

    Article  CAS  Google Scholar 

  • Gauss, K. A., Nelson-Overton, L. K., Siemsen, D. W., Gao, Y., Deleo, F. R., & Quinn, M. T. (2007). Role of NF-{kappa}B in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-{alpha}. J. Leukocite Biol., 82, 729–741.

    Article  CAS  Google Scholar 

  • Gilmore, T. D. (2006). Introduction to NF-kappaB: players, pathways, perspectives. Oncogene, 25, 6680–6684.

    Article  CAS  Google Scholar 

  • Goldberg, D. M., Yan, J., & Soleas, G. J. (2003). Absorption of three wine-related polyphenols in three different matrices by healthy subjects. Clin. Biochem., 36, 79–87.

    Article  CAS  Google Scholar 

  • Goldstein, J. L., DeBose-Boyd, R. A., & Brown, M. S. (2006). Protein sensors for membrane sterols. Cell, 124, 35–46.

    Article  CAS  Google Scholar 

  • Gouedard, C., Barouki, R., & Morel, Y. (2004). Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism. Mol. Cell. Biol., 24, 5209–5222.

    Google Scholar 

  • Guarente, L. (1999). Diverse and dynamic functions of the Sir silencing complex. Nat. Genet., 23, 281–285.

    Article  CAS  Google Scholar 

  • Guzik, T. J., West, N. E., Black, E., McDonald, D., Ratnatunga, C., Pillai, R., & Channon, K. M. (2000). Vascular superoxide production by NAD(P)H oxidase: association with endothelial dysfunction and clinical risk factors. Circ. Res., 86, E85–E90.

    CAS  Google Scholar 

  • Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybylowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G., & Channon, K. M. (2006). Coronary artery superoxide production and nox isoform expression in human coronary artery disease. Arterioscler. Thromb. Vasc. Biol., 26, 333–339.

    Article  CAS  Google Scholar 

  • Hayek, T., Fuhrman, B., Vaya, J., Rosenblat, M., Belinky, P., Coleman, R., Elis, A., & Aviram, M. (1997). Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation. Arterioscler. Thromb. Vasc. Biol., 17, 2744–2752.

    CAS  Google Scholar 

  • Henning, S. M., Aronson, W., Niu, Y., Conde, F., Lee, N. H., Seeram, N. P., Lee, R. P., Lu, J., Harris, D. M., Moro, A., Hong, J., Pak-Shan, L., Barnard, R. J., Ziaee, H. G., Csathy, G., Go, V. L., Wang, H., & Heber, D. (2006). Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption. J. Nutr., 136, 1839–1843.

    CAS  Google Scholar 

  • Henry-Vitrac, C., Desmouliére, A., Girard, D., Mérillon, J. M., & Krisa, S. (2006). Transport, deglycosylation, and metabolism of trans-piceid by small intestinal epithelial cells. Eur. J. Nutr., 45, 376–382.

    Article  CAS  Google Scholar 

  • Hoffmann, A., Natoli, G., & Ghosh, G. (2006). Transcriptional regulation via the NF-kappaB signaling module. Oncogene, 25, 6706–6716.

    Article  CAS  Google Scholar 

  • Hou, D. X., Masuzaki, S., Hashimoto, F., Uto, T., Tanigawa, S., Fujii, M., & Sakata, Y. (2007). Green tea proanthocyanidins inhibit cyclooxygenase-2 expression in LPS-activated mouse macrophages: molecular mechanisms and structure-activity relationship. Arch. Biochem. Biophys., 460, 67–74.

    Article  CAS  Google Scholar 

  • Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., Scherer, B., & Sinclair, D. A. (2003). Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature, 425, 191–196.

    Article  CAS  Google Scholar 

  • Huang, C., Jacobson, K., & Schaller, M. D. (2004). MAP kinases and cell migration. J. Cell Sci., 117, 4619–4628.

    Article  CAS  Google Scholar 

  • Iijima, K., Yoshizumi, M., Hashimoto, M., Akishita, M., Kozaki, K., Ako, J., Watanabe, T., Ohike, Y., Son, B., Yu, J., Nakahara, K., & Ouchi, Y. (2002). Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways. Circulation, 105, 2404–2410.

    Article  CAS  Google Scholar 

  • Imai, S., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000). Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature, 403, 795–800.

    Article  CAS  Google Scholar 

  • Infanger, D. W., Sharma, R. V., & Davisson, R. L. (2006). NADPH oxidases of the brain: distribution, regulation, and function. Antiox. Redox Signal., 8, 1583–1596.

    Article  CAS  Google Scholar 

  • Ivanov, V., Carr, A. C., & Frei, B. (2001). Red wine antioxidants bind to human lipoproteins and protect them from metal ion-dependent and -independent oxidation. J. Agric. Food Chem., 49, 4442–4449.

    Article  CAS  Google Scholar 

  • Jimenez, R., Lopez-Sepulveda, R., Kadmiri, M., Romero, M., Vera, R., Sanchez, M., Vargas, F., O’Valle, F., Zarzuelo, A., Duenas, M., Santos-Buelga, C., & Duarte, J. (2007). Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase. Free Rad. Biol. Med., 43, 462–473.

    Article  CAS  Google Scholar 

  • Jung, U. J., Kim, H. J., Lee, J. S., Lee, M. K., Kim, H. O., Park, E. J., Kim, H. K., Jeong, T. S., & Choi, M. S. (2003). Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects. Clin. Nutr., 22, 561–568.

    Article  CAS  Google Scholar 

  • Kaminski, W. E., Piehler, A., & Wenzel, J. J. (2006). ABC A-subfamily transporters: structure, function and disease. Biochim. Biophis. Acta, 1762, 510–524.

    CAS  Google Scholar 

  • Karin, M., & Ben-Neriah, Y. (2000). Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Ann. Rev. Immunol., 18, 621–663.

    Article  CAS  Google Scholar 

  • Karin, M., & Greten, F. R. (2005). NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol., 5, 749–759.

    Article  CAS  Google Scholar 

  • Kim, D., Nguyen, M. D., Dobbin, M. M., Fischer, A., Sananbenesi, F., Rodgers, J. T., Delalle, I., Baur, J. A., Sui, G., Armour, S. M., Puigserver, P., Sinclair, D. A., & Tsai, L. H. (2007). SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer’s disease and amyotrophic lateral sclerosis. EMBO J., 26, 3169–3179.

    Article  CAS  Google Scholar 

  • Kim, H. J., Oh, G. T., Park, Y. B., Lee, M. K., Seo, H. J., & Choi, M. S. (2004). Naringin alters the cholesterol biosynthesis and antioxidant enzyme activities in LDL receptor-knockout mice under cholesterol fed condition. Life Sci., 74, 1621–1634.

    Article  CAS  Google Scholar 

  • Kuhn, D. J., Burns, A. C., Kazi, A., & Dou, Q. P. (2004). Direct inhibition of the ubiquitin-proteasome pathway by ester bond-containing green tea polyphenols is associated with increased expression of sterol regulatory element-binding protein 2 and LDL receptor. Biochim. Biophis. Acta, 1682, 1–10.

    CAS  Google Scholar 

  • Lafay, S., Morand, C., Manach, C., Besson, C., & Scalbert, A. (2006). Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats. British J. Nutr., 96, 39–46.

    Article  CAS  Google Scholar 

  • Lamuela-Raventos, R. M., Covas, M. I., Fito, M., Marrugat, J., & de La Torre-Boronat, M. C. (1999). Detection of dietary antioxidant phenolic compounds in human LDL. Clin. Chem., 45, 1870–1872.

    CAS  Google Scholar 

  • Lee, S. O., Jeong, Y. J., Yu, M. H., Lee, J. W., Hwangbo, M. H., Kim, C. H., & Lee, I. S. (2006). Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. Biochem. Biophys. Res. Comm., 351, 118–125.

    Article  CAS  Google Scholar 

  • Leikert, J. F., Rathel, T. R., Wohlfart, P., Cheynier, V., Vollmar, A. M., & Dirsch, V. M. (2002). Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation, 106, 1614–1617.

    Article  CAS  Google Scholar 

  • Lin, S. J., Defossez, P. A., & Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science, 289, 2126–2128.

    Article  CAS  Google Scholar 

  • Liu, J. C., Chen, J. J., Chan, P., Cheng, C. F., & Cheng, T. H. (2003). Inhibition of cyclic strain-induced endothelin-1 gene expression by resveratrol. Hypertension, 42, 1198–1205.

    Article  CAS  Google Scholar 

  • Luo, J., Nikolaev, A. Y., Imai, S., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001). Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell, 107, 137–148.

    Article  CAS  Google Scholar 

  • Manach, C., Williamson, G., Morand, C., Scalbert, A., & Remesy, C. (2005). Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr., 81, 230S–242S.

    CAS  Google Scholar 

  • Mantei, N., Villa, M., Enzler, T., Wacker, H., Boll, W., James, P., Hunziker, W., & Semenza, G. (1988). Complete primary structure of human and rabbit lactase-phlorizin hydrolase: implications for biosynthesis, membrane anchoring and evolution of the enzyme. EMBO J., 7, 2705–2713.

    CAS  Google Scholar 

  • Masoro, E. J. (2000). Caloric restriction and aging: an update. Exp. Gerontol., 35, 299–305.

    Article  CAS  Google Scholar 

  • Maxwell, S., Cruickshank, A., & Thorpe, G. (1994). Red wine and antioxidant activity in serum. The Lancet, 344, 193–194.

    Article  CAS  Google Scholar 

  • McDougall, G, J., Fyffe, S., Dobson, P., & Stewart, D. (2005). Anthocyanins from red wine – their stability under simulated gastrointestinal digestion. Phytochemistry, 66, 2540–2548.

    Article  CAS  Google Scholar 

  • Mink, P. J., Scrafford, C. G., Barraj, L. M., Harnack, L., Hong, C. P., Nettleton, J. A., & Jacobs, D. R. Jr. (2007). Flavonoid intake and cardiovascular disease mortality: a prospective study in postmenopausal women. Am. J. Clin. Nutr., 85, 895–909.

    CAS  Google Scholar 

  • Moreno, M. U., San Jose, G., Orbe, J., Paramo, J. A., Beloqui, O., Diez, J., & Zalba, G. (2003). Preliminary characterisation of the promoter of the human p22(phox) gene: identification of a new polymorphism associated with hypertension. FEBS Letters, 542, 27–31.

    Article  CAS  Google Scholar 

  • Mukamal, K. J., Massaro, J. M., Ault, K. A., Mittleman, M. A., Sutherland, P. A., Lipinska, I., Levy, D., D’Agostino, R. B., & Tofler, G. H. (2005). Alcohol consumption and platelet activation and aggregation among women and men: the Framingham Offspring Study. Alcohol. Clin. Exp. Res., 29, 1906–1912.

    Article  CAS  Google Scholar 

  • Mullen, E., Brown, R. M., Osborne, T. F., & Shay, N. F. (2004). Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. J. Nutr., 134, 2942–2947.

    CAS  Google Scholar 

  • Mursu, J., Voutilainen, S., Nurmi, T., Rissanen, T. H., Virtanen, J. K., Kaikkonen, J., Nyyssönen, K., & Salonen, J. T. (2004). Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans. Free Rad. Biol. Med., 37, 1351–1359.

    Article  CAS  Google Scholar 

  • Nam, N. H. (2006). Naturally occurring NF-kappaB inhibitors. Mini Reviews in Medicinal Chemistry, 6, 945–951.

    Article  CAS  Google Scholar 

  • Nardini, M., Cirillo, E., Natella, F., & Scaccini, C. (2002). Absorption of phenolic acids in humans after coffee consumption. J. Agric. Food Chem., 50, 5735–5741.

    Article  CAS  Google Scholar 

  • Natella, F., Nardini, M., Belelli, F., & Scaccini, C. (2007). Coffee drinking induces incorporation of phenolic acids into LDL and increases the resistance of LDL to ex vivo oxidation in humans. Am. J. Clin. Nutr., 86, 604–609.

    CAS  Google Scholar 

  • Ndiaye, M., Chataigneau, M., Lobysheva, I., Chataigneau, T., & Schini-Kerth, V. B. (2005). Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J., 19, 455–457.

    CAS  Google Scholar 

  • Nemeth, K., Plumb, G. W., Berrin, J. G., Juge, N., Jacob, R., Naim, H. Y., Williamson, G., Swallow, D. M., & Kroon, P. A. (2003). Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans. Eur. J. Nutr., 42, 29–42.

    Article  CAS  Google Scholar 

  • Nigdikar, S. V., Williams, N. R., Griffin, B. A., & Howard, A. N. (1998). Consumption of red wine polyphenols reduces the susceptibility of low-density lipoproteins to oxidation in vivo. Am. J. Clin. Nutr., 68, 258–265.

    CAS  Google Scholar 

  • Oak, M. H., Chataigneau, M., Keravis, T., Chataigneau, T., Beretz, A., Andriantsitohaina, R., Stoclet, J. C., Chang, S. J., & Schini-Kerth, V. B. (2003). Red wine polyphenolic compounds inhibit vascular endothelial growth factor expression in vascular smooth muscle cells by preventing the activation of the p38 mitogen-activated protein kinase pathway. Arterioscler. Thromb. Vasc. Biol., 23, 1001–1007.

    Article  CAS  Google Scholar 

  • Oak, M. H., El Bedoui, J., Anglard, P., & Schini-Kerth, V. B. (2004). Red wine polyphenolic compounds strongly inhibit pro-matrix metalloproteinase-2 expression and its activation in response to thrombin via direct inhibition of membrane type 1-matrix metalloproteinase in vascular smooth muscle cells. Circulation, 110, 1861–1867.

    Article  CAS  Google Scholar 

  • O’Byrne, D. J., Devaraj, S., Grundy, S. M., & Jialal, I. (2002). Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am. J. Clin. Nutr., 76, 1367–1374.

    CAS  Google Scholar 

  • Olthof, M. R., Hollman, P. C., Buijsman, M. N., van Amelsvoort, J. M., & Katan, M. B. (2003). Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J. Nutr., 133, 1806–1814.

    CAS  Google Scholar 

  • Oram, J. F., & Vaughan, A. M. (2006). ATP-Binding cassette cholesterol transporters and cardiovascular disease. Circ. Res., 99, 1031–1043.

    Article  CAS  Google Scholar 

  • Pal, S., Ho, N., Santos, C., Dubois, P., Mamo, J., Croft, K., & Allister, E. (2003). Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. J. Nutr., 133, 700–706.

    CAS  Google Scholar 

  • Pal, S., Ho, S. S., & Takechi, R. (2005). Red wine polyphenolics suppress the secretion of ApoB48 from human intestinal CaCo-2 cells. J. Agric. Food Chem., 53, 2767–2772.

    Article  CAS  Google Scholar 

  • Pignatelli, P., Di Santo, S., Buchetti, B., Sanguigni, V., Brunelli, A., & Violi, F. (2006a). Polyphenols enhance platelet nitric oxide by inhibiting protein kinase C-dependent NADPH oxidase activation: effect on platelet recruitment. FASEB J., 20, 1082–1089.

    Article  CAS  Google Scholar 

  • Pignatelli, P., Ghiselli, A., Buchetti, B., Carnevale, R., Natella, F., Germano, G., Fimognari, F., Di Santo, S., Lenti, L., & Violi, F. (2006b). Polyphenols synergistically inhibit oxidative stress in subjects given red and white wine. Atherosclerosis, 188, 77–83.

    Article  CAS  Google Scholar 

  • Pitsavos, C., Makrilakis, K., Panagiotakos, D. B., Chrysohoou, C., Ioannidis, I., Dimosthenopoulos, C., Stefanadis, C., & Katsilambros, N. (2005). The J-shape effect of alcohol intake on the risk of developing acute coronary syndromes in diabetic subjects: the CARDIO2000 II Study. Diabet. Med., 22, 243–248.

    Article  CAS  Google Scholar 

  • Renaud, S., & de Lorgeril, M. (1992). Wine, alcohol, platelets, and the French paradox for coronary heart disease. The Lancet, 339, 1523–1526.

    Article  CAS  Google Scholar 

  • Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005). Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature, 434, 113–138.

    Article  CAS  Google Scholar 

  • Roux, P. P., & Blenis, J. (2004). ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev., 68, 320–344.

    Article  CAS  Google Scholar 

  • Sanchez, M., Lodi, F., Vera, R., Villar, I. C., Cogolludo, A., Jimenez, R., Moreno, L., Romero, M., Tamargo, J., Perez-Vizcaino, F., & Duarte, J. (2007). Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta. J. Nutr., 137, 910–915.

    CAS  Google Scholar 

  • Sarr, M., Chataigneau, M., Martins, S., Schott, C., El Bedoui, J., Oak, M. H., Muller, B., Chataigneau, T., & Schini-Kerth, V. B. (2006). Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc. Res., 71, 794–802.

    Article  CAS  Google Scholar 

  • Sasaki, S. (2000). Alcohol and its relation to all-cause and cardiovascular mortality. Acta Cardiol., 55, 151–156.

    Article  CAS  Google Scholar 

  • Scalbert, A., & Williamson, G. (2000). Dietary intake and bioavailability of polyphenols. J. Nutr., 130, 2073S–2085S.

    CAS  Google Scholar 

  • Schubert, S. Y., Neeman, I., & Resnick, N. (2002). A novel mechanism for the inhibition of NF-kappaB activation in vascular endothelial cells by natural antioxidants. FASEB J., 16, 1931–1933.

    CAS  Google Scholar 

  • Sembries, S., Dongowski, G., Mehrlander, K., Will, F., & Dietrich, H. (2006). Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats. J. Agric. Food Chem., 54, 10269–10280.

    Article  CAS  Google Scholar 

  • Serafini, M., Maiani, G., & Ferro-Luzzi, A. (1998). Alcohol-free red wine enhances plasma antioxidant capacity in humans. J. Nutr., 128, 1003–1007.

    CAS  Google Scholar 

  • Sesso, H. D. (2001). Alcohol and cardiovascular health: recent findings. Am. J. Cardiovasc. Drug.: drugs, devices, and other interventions, 1, 167–172.

    CAS  Google Scholar 

  • Sesso, H. D., Gaziano, J. M., Liu, S., & Buring, J. E. (2003). Flavonoid intake and the risk of cardiovascular disease in women. Am. J. Clin. Nutr., 77, 1400–1408.

    CAS  Google Scholar 

  • Sevov, M., Elfineh, L., & Cavelier, L. B. (2006). Resveratrol regulates the expression of LXR-alpha in human macrophages. Biochem. Biophys. Res. Comm., 348, 1047–1054.

    Article  CAS  Google Scholar 

  • Shahidi, F., Janitha, P. K., & Wanasundara, P. D. (1992). Phenolic antioxidants. Crit. Rev. Food Sci. Nutr., 32, 67–103.

    Article  CAS  Google Scholar 

  • Shimizu, M., Kobayashi, Y., Suzuki, M., Satsu, H., & Miyamoto, Y. (2000). Regulation of intestinal glucose transport by tea catechins. Biofactors, 13, 61–65.

    CAS  Google Scholar 

  • Silberberg, M., Morand, C., Mathevon, T., Besson, C., Manach, C., Scalbert, A., & Remesy, C. (2006). The bioavailability of polyphenols is highly governed by the capacity of the intestine and of the liver to secrete conjugated metabolites. Eur. J. Nutr., 45, 88–96.

    Article  CAS  Google Scholar 

  • Simonetti, P., Gardana, C., & Pietta, P. (2001). Plasma levels of caffeic acid and antioxidant status after red wine intake. J. Agric. Food Chem., 49, 5964–5968.

    Article  CAS  Google Scholar 

  • Sohal, R. S., & Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science, 273, 59–63.

    Article  CAS  Google Scholar 

  • Sorescu, D., Weiss, D., Lassegue, B., Clempus, R. E., Szocs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., Taylor, W. R., & Griendling, K. K. (2002). Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation, 105, 1429–1435.

    Article  CAS  Google Scholar 

  • St Leger, A. S., Cochrane, A. L., & Moore, F. (1979). Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. The Lancet, 1, 1017–1020.

    Article  CAS  Google Scholar 

  • Stein, J. H., Keevil, J. G., Wiebe, D. A., Aeschlimann, S., & Folts, J. D. (1999). Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation, 100, 1050–1055.

    CAS  Google Scholar 

  • Stoclet, J. C., Chataigneau, T., Ndiaye, M., Oak, M. H., El Bedoui, J., & Chataigneau, M., (2004). Schini-Kerth, V. B. Vascular protection by dietary polyphenols. Eur. J. Pharmacol., 500, 299–313.

    Google Scholar 

  • Su, H. C., Hung, L. M., & Chen, J. K. (2006). Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am. J. Physiol. Endocrinol. Metab., 290, E1339–E1346.

    Article  CAS  Google Scholar 

  • Takechi, R., Hiramatsu, N., Mamo, J. C., & Pal, S. (2004). Red wine polyphenolics suppress the secretion and the synthesis of Apo B48 from human intestinal CaCo-2 cells. Biofactors, 22, 181–183.

    CAS  Google Scholar 

  • Terra, X., Valls, J., Vitrac, X., Merrillon, J. M., Arola, L., Ardevol, A., Blade, C., Fernandez-Larrea, J., Pujadas, G., Salvado, J., & Blay, M. (2007). Grape-seed procyanidins act as antiinflammatory agents in endotoxin-stimulated RAW 264.7 macrophages by inhibiting NFkB signaling pathway. J. Agric. Food Chem., 55, 4357–4365.

    Article  CAS  Google Scholar 

  • Tissenbaum, H. A., & Guarente, L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature, 410, 227–230.

    Article  CAS  Google Scholar 

  • Tontonoz, P., & Mangelsdorf, D. J. (2003). Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol., 17, 985–993.

    Article  CAS  Google Scholar 

  • Ukil, A., Maity, S., & Das, P. K. (2006). Protection from experimental colitis by theaflavin-3,3’-digallate correlates with inhibition of IKK and NF-kappaB activation. Br. J. Pharmacol., 149, 121–131.

    Article  CAS  Google Scholar 

  • Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T., Mazur, M., & Telser, J. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol., 39, 44–84.

    Article  CAS  Google Scholar 

  • Vayalil, P. K., Mittal, A., & Katiyar, S. K. (2004). Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B. Carcinogenesis, 25, 987–995.

    Article  CAS  Google Scholar 

  • Vaziri, H., Dessain, S. K., Ng Eaton, E., Imai, S. I., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001). hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell, 107, 149–159.

    Article  CAS  Google Scholar 

  • Vidal, R., Hernandez-Vallejo, S., Pauquai, T., Texier, O., Rousset, M., Chambaz, J., Demignot, S., & Lacorte, J. M. (2005). Apple procyanidins decrease cholesterol esterification and lipoprotein secretion in Caco-2/TC7 enterocytes. J. Lipid Res., 46, 258–268.

    Article  CAS  Google Scholar 

  • Vita, J. A. (2005). Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am. J. Clin. Nutr., 81, 292S–297S.

    CAS  Google Scholar 

  • Vitaglione, P., Sforza, S., Galaverna, G., Ghidini, C., Caporaso, N., Vescovi, P. P., Fogliano, V., & Marchelli, R. (2005). Bioavailability of trans-resveratrol from red wine in humans. Mol. Nutr. Food Res., 49, 495–504.

    Article  CAS  Google Scholar 

  • Wallerath, T., Deckert, G., Ternes, T., Anderson, H., Li, H., Witte, K., & Forstermann, U. (2002). Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation, 106, 1652–1658.

    Article  CAS  Google Scholar 

  • Wheeler, D. S., Catravas, J. D., Odoms, K., Denenberg, A., Malhotra, V., & Wong, H. R. (2004). Epigallocatechin-3-gallate, a green tea-derived polyphenol, inhibits IL-1 beta-dependent proinflammatory signal transduction in cultured respiratory epithelial cells. J. Nutr., 134, 1039–1044.

    CAS  Google Scholar 

  • Whitehead, T. P., Robinson, D., Allaway, S., Syms, J., & Hale, A. (1995). Effect of red wine ingestion on the antioxidant capacity of serum. Clin. Chem., 41, 32–35.

    CAS  Google Scholar 

  • Wilcox, L. J., Borradaile, N. M., de Dreu, L. E., & Huff, M. W. (2001). Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J. Lipid Res., 42, 725–734.

    CAS  Google Scholar 

  • Witztum, J. L., & Steinberg, D. (1991). Role of oxidized low density lipoprotein in atherogenesis. J. Clin. Inves., 88, 1785–1792.

    Article  CAS  Google Scholar 

  • Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. A. (2004). Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature, 430, 686–689.

    Google Scholar 

  • World Health Organisation. (1989). World health statistics annual. Geneve, World Health Organisation.

    Google Scholar 

  • Xia, M., Hou, M., Zhu, H., Ma, J., Tang, Z., Wang, Q., Li, Y., Chi, D., Yu, X., Zhao, T., Han, P., Xia, X., & Ling, W. (2005). Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway. J. Biol. Chem., 280, 36792–36801.

    Article  CAS  Google Scholar 

  • Xia, M., Ling, W., Zhu, H., Wang, Q., Ma, J., Hou, M., Tang, Z., Li, L., & Ye, Q. (2007). Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution. Arterioscler. Thromb. Vasc. Biol., 27, 519–524.

    Article  CAS  Google Scholar 

  • Xu, J. W., Ikeda, K., & Yamori, Y. (2004). Genistein inhibits expressions of NADPH oxidase p22phox and angiotensin II type 1 receptor in aortic endothelial cells from stroke-prone spontaneously hypertensive rats. Hypertens. Res., 27, 675–683.

    Article  CAS  Google Scholar 

  • Yang, F., Oz, H. S., Barve, S., de Villiers, W. J., McClain, C. J., & Varilek, G. W. (2001). The green tea polyphenol (-)-epigallocatechin-3-gallate blocks nuclear factor-kappa B activation by inhibiting I kappa B kinase activity in the intestinal epithelial cell line IEC-6. Molecular Pharmacology, 60, 528–533.

    CAS  Google Scholar 

  • Yang, H., Baur, J. A., Chen, A., Miller, C., Adams, J. K., Kisielewski, A., Howitz, K. T., Zipkin, R. E., & Sinclair, D. A. (2007). Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell, 6, 35–43.

    Article  CAS  Google Scholar 

  • Yang, T. T., & Koo, M. W. (2000). Chinese green tea lowers cholesterol level through an increase in fecal lipid excretion. Life Sci.s, 66, 411–423.

    Google Scholar 

  • Ying, C. J., Xu, J. W., Ikeda, K., Takahashi, K., Nara, Y., & Yamori, Y. (2003). Tea polyphenols regulate nicotinamide adenine dinucleotide phosphate oxidase subunit expression and ameliorate angiotensin II-induced hyperpermeability in endothelial cells. Hypertens. Res., 26, 823–828.

    Article  CAS  Google Scholar 

  • Zalba, G., Fortuño, A., Orbe, J., San Jose, G., Moreno, M. U., Belzunce, M., Rodriguez, J. A., Beloqui, O., Paramo, J. A., & Diez, J. (2007). Phagocytic NADPH oxidase-dependent superoxide production stimulates matrix metalloproteinase-9: implications for human atherosclerosis. Arterioscler. Thromb. Vasc. Biol., 27, 587–593.

    Article  CAS  Google Scholar 

  • Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., & Fernandez, M. L. (2005). Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J. Nutr., 135, 1911–1917.

    CAS  Google Scholar 

  • Zhen, M. C., Huang, X. H., Wang, Q., Sun, K., Liu, Y. J., Li, W., Zhang, L. J., Cao, L. Q., & Chen, X. L. (2006). Green tea polyphenol epigallocatechin-3-gallate suppresses rat hepatic stellate cell invasion by inhibition of MMP-2 expression and its activation. Acta Pharmacol. Sin., 27, 1600–1607.

    Article  CAS  Google Scholar 

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Dávalos, A., Lasunción, M.A. (2009). Health-Promoting Effects of Wine Phenolics. In: Moreno-Arribas, M.V., Polo, M.C. (eds) Wine Chemistry and Biochemistry. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74118-5_25

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