Abstract
There is increasing evidence of the local effects within the gastro intestinal tract and the systemic functions of human milk oligosaccharides (HMO). In addition to the vast majority of in vitro data, animal studies underline the high potential of HMO to influence very different processes. HMO probably influence the composition of the gut microflora through effects on the growth of bifidus bacteria.Whether the concomitant low number of pathogenic microorganisms in breastfed infants is also caused by HMO is an intriguing question that still has yet to be proven. Due to the similarity of HMO to epithelial cell surface carbohydrates, an inhibitory effect on the adhesion of pathogens to the cell surface is most likely. If this could be shown in humans, HMO would provide a new way to prevent or treat certain infections. It would also indicate supplementing infant formula based on cow’s milk with HMO, as those oligosaccharides are either not detectable or present only in low numbers in bovine milk. As some HMO can be absorbed and circulate in blood, systemic effects may also be influenced. Due to their similarities to selectin ligands, HMO have been tested in in vitro studies demonstrating their anti-inflammatory abilities. For example, it has been shown that sialic acid-containing oligosaccharides reduce the adhesion of leukocytes to endothelial cells, an indication for an immune regulatory effect of certain HMO. We cover these topics after a short introduction on the structures of HMO, with a particular emphasis on their blood group and secretor specificity.
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References
Adlerberth, I. (1997). The establishment of a normal intestinal microflora in the newborn infant. In L. A. Hanson and R. B. Yolken (Eds.), Probiotics, Other Nutritional Factors, and Intestinal Flora (pp. 63–78). 42nd Nestlé Nutrition Workshop in Beijing (China). New York: Raven Press.
Beachey, E. H. (1981). Bacterial adherence: Adhesin-receptor interactions mediating the attachment of bacteria to mucosal surfaces. Journal of Infectious Diseases, 143, 325–345.
Berg, E. L., Magnani, J., Warnock, R. A., Robinson, M. K., Butcher, E. C. (1992). Comparison of L-Selectin and E-Selectin Ligand Specificities: The L-Selection Can Bind the E-Selection Ligands Sialyl Lex and Sialyl Lea. Biochemical and Biophysical Research Communicaitons, 184, 2, 1048–1055.
Inhibition of monocyte, lymphocyte, and neutrophil adhesion to endothelial cells by human milk oligosaccharides. Thrombosis and Haemostasis, 92, 1402–1410.
Bode, L., Rudloff, S., Kunz, C., Strobel, S.,&Klein, N. (2004b). Human milk oligosaccharides reduce platelet-neutrophil complex formation leading to a decrease in neutrophil ß2 integrin expression. Journal of Leukocyte Biology, 76, 1–7.
Carden, D. L.,&Granger, D. N. (2000). Pathophysiology of ischemia-reperfusion injury. Journal of Pathology, 190, 255–266.
Engfer, M. B., Stahl, B., Finke, B., Sawatzki, G.,&Daniel, H. (2000). Human milk oligosaccharides are resistant to enzymatic hydrolysis in the upper gastrointestinal tract. American Journal of Clinical Nutrition, 71, 1589–1596.
Gibson, G.,&Roberfroid, M. B. (1995). Dietary modulaton of the human colonic microbiota: Introducing the concept of prebiotics. Journal of Nutrition, 125, 1401–1412.
Gnoth, M. J., Kunz, C., Kinne-Saffran, E.,&Rudloff, S. (2000). Human milk oligosaccharides are minimally digested in vitro. Journal of Nutrition, 130, 3014–3020.
György, P. (1953). A hitherto unrecognized biochemical difference between human milk and cow¨s milk. Pediatrics, 11, 98–108.
Idänpään-Heikkilä, I., Simon, P. M., Zopf, D., Vullo, T., Cahill, P., Sokol, K.,&Tuomanen, E. (1997). Oligosaccharides interfere with the establishment andprogression of experimental pneumococcal pneumonia. Journal of Infectious Diseases, 176, 704–712.
Kannagi, R. (2002). Regulatory roles of carbohydrate ligands for selectins in the homing of lymphocytes. Current Opinion in Structural Biology, 12, 599–608.
Karlsson, K. A. (1995). Microbial recognition of target-cell glycoconjugates. Current Opinion in Structural Biology, 5, 622–635.
Kosloske, A. M. (2001). Breast milk decreases the risk of neonatal necrotizing enterocolitis. Adv Nutr Res, 10,123–137.
Kuntz S., Henkel, C., Rudloff, S.,&Kunz, C. (2003). Effects of neutral oligosaccharides from human milk on proliferation, differentiation and apoptosis in intestinal epithelial cells. Proceedings of the Annual Meeting of Experimental Biology, San Diego.
Kunz, C. et al. (1996).
Kunz, C., Rudloff, S., Hintermann, A., Pohlentz, G., Egge, H. (1996). High-pH anion exchange chromatography with pulsed amperometric detection and molar response facotr of human milk oligosacchrides. J Chromatogr B Biomed Appl, 685, 211–221.
Kunz, C., Rudloff, S., Schad, W.,&Braun, D. (1999). Lactose-derived oligosaccharides in the milk of elephants: Comparison with human milk. British Journal of Nutrition, 82, 391–399.
Kunz, C., Rudloff, S., Baier, W., Klein, N.,&Strobel, S. (2000). Oligosaccharides in human milk. Structural, functional and metabolic aspects. Annual Review of Nutrition, 20, 699–722.
Lasky, L. A. (1995). Selectin-carbohydrate interactions and the initiation of the inflammatory response. Annual Review of Biochemistry, 64, 113–139.
Lucas, A., Cole, T. J. (1990). Breast milk and neonatal necrotizing enterocolits. Lancet, 336, 1519–1523.
McEver, R. P. (1994). Selectins. Curr Opin Immunol, 6, 75–84.
Moro, E. (1900). Morphologische und bakteriologische Untersuchungen über die Darmbakterien des Säuglings: Die Bakteriumflora des normalen Frauenmilchstuhls [in German]. Jahrbuch Kinderh, 61, 686–734.
Morrow, A. L., Ruiz-Palacios, G. M., Altaye, M., Jiang, X., Guerrero, M. L., Meinzen-Derr, J. K., Farkas, T., Chaturvedi, P., Pickering, L. K.,&Newburg, D. S. (2004). Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. Journal of Pediatrics, 145, 297–303.
Mysore, J. V., Wigginton, T., Simon, P. M., Zopf, D., Heman-Ackah, L. M.,&Dubois, A. (1999). Treatment of Helicobacter pylori infection in rhesus monkeys using a novel antiadhesion compound. Gastroenterology, 117, 1316–1325.
Ofek, I.,&Sharon, N. (1990). Adhesins as lectins: Specificity and role in infection. Current Topics in Microbiology and Immunology, 151, 91–114.
Rudloff, S., Pohlentz, G., Diekmann, L., Egge, H.,&Kunz, C. (1996). Urinary excretion of lactose and oligosaccharides in preterm infants fed human milk or infant formula. Acta Paediatrics, 85, 598–603.
Sharon, N.,&Ofek, I. (2000). Safe as mother's milk: Carbohydrates as future anti-adhesion drugs for bacterial diseases. Glycoconjugate Journal, 17, 659–664.
Springer, T. A. (1990). Adhesion receptors of the immune system. Nature, 346, 425–434.
Tungland, B. C.,&Meyer, P. D. (2002). Dietary fiber and human health. Comprehensive Reviews in Food Science and Food Safety, Vol. 2.
Ukkonen, P., Varis, K., Jernfors, M., Herva, E., Jokinen, J., Ruokokoski, E., Zopf, D.,&Kilpi, T . (2000). Treatment of acute otitis media with an antiadhesive oligosaccharide: A randomised, double-blind, placebo-controlled trial. Lancet, 356, 1398–1402.
Wright, A. L., Holberg, C. J., Martinez, F. D., et al. (1989) Breast feeding and lower respiratory tract illness in the first year of life. Group Health Medical Associates. BMJ, 299, 946–949.
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Kunz, C., Rudloff, S. (2008). Potential Anti-Inflammatory and Anti-Infectious Effects of Human Milk Oligosaccharides. In: Bösze, Z. (eds) Bioactive Components of Milk. Advances in Experimental Medicine and Biology, vol 606. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74087-4_18
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DOI: https://doi.org/10.1007/978-0-387-74087-4_18
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