Skip to main content

Toll-like Receptors, Natural Killer Cells and Innate Immunity

  • Conference paper
Current Topics in Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 598))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aderem, A. and Ulevitch, R. J. (2000) Toll-like receptors in the induction of the innate immune response. Nature. 406(6797), 782-7.

    Article  PubMed  CAS  Google Scholar 

  • Akira, S. and Takeda, K. (2004) Toll-like receptor signalling. Nat Rev Immunol. 4(7), 499-511.

    Article  PubMed  CAS  Google Scholar 

  • Andoniou, C. E., van Dommelen, S. L., Voigt, V., Andrews, D. M., Brizard, G., Asselin-Paturel, C., Delale, T., Stacey, K. J., Trinchieri, G. and Degli-Esposti, M. A. (2005) Interaction between conventional dendritic cells and natural killer cells is integral to the activation of effective antiviral immunity. Nat Immunol. 6(10), 1011-9.

    Article  PubMed  CAS  Google Scholar 

  • Baratin, M., Roetynck, S., Lepolard, C., Falk, C., Sawadogo, S., Uematsu, S., Akira, S., Ryffel, B., Tiraby, J. G., Alexopoulou, L., Kirschning, C. J., Gysin, J., Vivier, E. and Ugolini, S. (2005) Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum. Proc Natl Acad Sci U S A. 102(41), 14747-52.

    Article  PubMed  CAS  Google Scholar 

  • Becker, I., Salaiza, N., Aguirre, M., Delgado, J., Carrillo-Carrasco, N., Kobeh, L. G., Ruiz, A., Cervantes, R., Torres, A. P., Cabrera, N., Gonzalez, A., Maldonado, C. and Isibasi, A. (2003) Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2. Mol Biochem Parasitol. 130(2), 65-74.

    Article  PubMed  CAS  Google Scholar 

  • Beutler, B., Jiang, Z., Georgel, P., Crozat, K., Croker, B., Rutschmann, S.,Du, X. and Hoebe, K. (2006) Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu Rev Immunol. 24, 353-89.

    Article  PubMed  CAS  Google Scholar 

  • Blach-Olszewska, Z. (2005) Innate immunity: cells, receptors, and signaling pathways. Arch Immunol Ther Exp. 53, 245-253.

    CAS  Google Scholar 

  • Bowie, A. G. and Haga, I. R. (2005) The role of Toll-like receptors in the host response to viruses. Mol Immunol. 42(8), 859-67.

    Article  PubMed  CAS  Google Scholar 

  • Burns, K., Martinon, F., Esslinger, C., Pahl, H., Schneider, P., Bodmer, J. L., Di Marco, F., French, L. and Tschopp, J. (1998) MyD88, an adapter protein involved in interleukin-1 signaling. J Biol Chem. 273(20), 12203-9.

    Article  PubMed  CAS  Google Scholar 

  • Cerwenka, A. and Lanier, L. L. (2001) Natural killer cells, viruses and cancer. Nat Rev Immunol. 1(1), 41-9.

    Article  PubMed  CAS  Google Scholar 

  • Chace, J. H., Hooker, N. A., Mildenstein, K. L., Krieg, A. M. and Cowdery, J. S. (1997) Bacterial DNA-induced NK cell IFN-gamma production is dependent on macrophage secretion of IL-12. Clin Immunol Immunopathol. 84(2), 185-93.

    Article  PubMed  CAS  Google Scholar 

  • Chalifour, A., Jeannin, P., Gauchat, J. F., Blaecke, A., Malissard, M., N’Guyen, T., Thieblemont, N. and Delneste, Y. (2004) Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood. 104(6), 1778-83.

    Article  PubMed  CAS  Google Scholar 

  • Chan, C. W., Crafton, E., Fan, H. N., Flook, J., Yoshimura, K., Skarica, M., Brockstedt, D., Dubensky, T. W., Stins, M. F., Lanier, L. L., Pardoll, D. M. and Housseau, F. (2006) Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med. 12(2), 207-13.

    Article  PubMed  CAS  Google Scholar 

  • Colucci, F., Di Santo, J. P. and Leibson, P. J. (2002) Natural killer cell activation in mice and men: different triggers for similar weapons? Nat Immunol. 3(9), 807-13.

    Article  PubMed  CAS  Google Scholar 

  • Eriksson, M., Meadows, S. K., Basu, S., Mselle, T. F., Wira, C. R. and Sentman, C. L. (2006) TLRs mediate IFN-gamma production by human uterine NK cells in endometrium. J Immunol. 176(10), 6219-24.

    PubMed  CAS  Google Scholar 

  • Fehniger, T. A., Cooper, M. A., Nuovo, G. J., Cella, M., Facchetti, F., Colonna, M. and Caligiuri, M. A. (2003) CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood. 101(8), 3052-7.

    Article  PubMed  CAS  Google Scholar 

  • Gorski, K. S., Waller, E. L., Bjornton-Severson, J., Hanten, J. A., Riter, C. L., Kieper, W. C., Gorden, K. B., Miller, J. S., Vasilakos, J. P., Tomai, M. A. and Alkan, S. S. (2006) Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol. 18(7), 1115-26.

    Article  PubMed  CAS  Google Scholar 

  • Hart, O. M., Athie-Morales, V., O’Connor, G. M. and Gardiner, C. M. (2005) TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol. 175(3), 1636-42.

    PubMed  CAS  Google Scholar 

  • Honda, K. and Taniguchi, T. (2006) IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol. 6(9), 644-58.

    Article  PubMed  CAS  Google Scholar 

  • Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdorfer, B., Giese, T., Endres, S. and Hartmann, G. (2002) Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol. 168(9), 4531-7.

    PubMed  CAS  Google Scholar 

  • Janeway, C. A., Jr. and Medzhitov, R. (1999) Lipoproteins take their toll on the host. Curr Biol. 9(23), R879-82.

    Article  PubMed  CAS  Google Scholar 

  • Jiang, Z., Mak, T. W., Sen, G. and Li, X. (2004) Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A. 101(10), 3533-8.

    Article  PubMed  CAS  Google Scholar 

  • Johansson, S., Berg, L., Hall, H. and Hoglund, P. (2005) NK cells: elusive players in autoimmunity. Trends Immunol. 26(11), 613-8.

    Article  PubMed  CAS  Google Scholar 

  • Kalinski, P., Giermasz, A., Nakamura, Y., Basse, P., Storkus, W. J., Kirkwood, J. M. and Mailliard, R. B. (2005) Helper role of NK cells during the induction of anticancer responses by dendritic cells. Mol Immunol. 42(4), 535-9.

    Article  PubMed  CAS  Google Scholar 

  • Kamath, A. T., Sheasby, C. E. and Tough, D. F. (2005) Dendritic cells and NK cells stimulate bystander T cell activation in response to TLR agonists through secretion of IFN-alpha beta and IFN-gamma. J Immunol. 174(2), 767-76.

    PubMed  CAS  Google Scholar 

  • Kawai, T. and Akira, S. (2006) TLR signaling. Cell Death Differ. 13(5), 816-25.

    Article  PubMed  CAS  Google Scholar 

  • Lanier, L. L. (2005) NK cell recognition. Annu Rev Immunol. 23, 225-74.

    Article  PubMed  CAS  Google Scholar 

  • Lauwerys, B. R., Garot, N., Renauld, J. C. and Houssiau, F. A. (2000) Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18. J Immunol. 165(4), 1847-53.

    PubMed  CAS  Google Scholar 

  • Lauzon, N. M., Mian, F., MacKenzie, R. and Ashkar, A. A. (2006) The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity. Cellular Immunology. doi:10.1016/j.cellimm.2006.08.004 (in press).

    Google Scholar 

  • Lemaitre, B. (2004) The road to Toll. Nat Rev Immunol. 4(7), 521-7.

    Article  PubMed  CAS  Google Scholar 

  • Lieberman, L. A. and Hunter, C. A. (2002) Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells. Microbes Infect. 4(15), 1531-8.

    Article  PubMed  CAS  Google Scholar 

  • Magor, B. G. and Magor, K. E. (2001) Evolution of effectors and receptors of innate immunity. Dev Comp Immunol. 25(8–9), 651-82.

    Article  PubMed  CAS  Google Scholar 

  • Medzhitov, R. and Janeway, C., Jr. (2000) Innate immune recognition: mechanisms and pathways. Immunol Rev. 173, 89-97.

    Article  PubMed  CAS  Google Scholar 

  • Miggin, S. M. and O’Neill L, A. (2006) New insights into the regulation of TLR signaling. J Leukoc Biol. 80(2), 220-6.

    Article  PubMed  CAS  Google Scholar 

  • Pandey, S. and Agrawal, D. K. (2006) Immunobiology of Toll-like receptors: emerging trends. Immunol Cell Biol. 84(4), 333-41.

    Article  PubMed  CAS  Google Scholar 

  • Pisegna, S., Pirozzi, G., Piccoli, M., Frati, L., Santoni, A. and Palmieri, G. (2004) p38 MAPK activation controls the TLR3-mediated up-regulation of cytotoxicity and cytokine production in human NK cells. Blood. 104(13), 4157-64.

    Article  PubMed  CAS  Google Scholar 

  • Raulet, D. H. (2004) Interplay of natural killer cells and their receptors with the adaptive immune response. Nat Immunol. 5(10), 996-1002.

    Article  PubMed  CAS  Google Scholar 

  • Roda, J. M., Parihar, R. and Carson, W. E., 3rd (2005) CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells. J Immunol. 175(3), 1619-27.

    PubMed  CAS  Google Scholar 

  • Schleicher, U., Hesse, A. and Bogdan, C. (2005) Minute numbers of contaminant CD8+ T cells or CD11b+CD11c+ NK cells are the source of IFN-gamma in IL-12/IL-18-stimulated mouse macrophage populations. Blood. 105(3), 1319-28.

    Article  PubMed  CAS  Google Scholar 

  • Schmidt, K. N., Leung, B., Kwong, M., Zarember, K. A., Satyal, S., Navas, T. A., Wang, F. and Godowski, P. J. (2004) APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J Immunol. 172(1), 138-43.

    PubMed  CAS  Google Scholar 

  • Sivori, S., Carlomagno, S., Moretta, L. and Moretta, A. (2006) Comparison of different CpG oligodeoxynucleotide classes for their capability to stimulate human NK cells. Eur J Immunol. 36(4), 961-7.

    Article  PubMed  CAS  Google Scholar 

  • Sivori, S., Falco, M., Della Chiesa, M., Carlomagno, S., Vitale, M., Moretta, L. and Moretta, A. (2004) CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. Proc Natl Acad Sci U S A. 101(27), 10116-21.

    Article  PubMed  CAS  Google Scholar 

  • Strengell, M., Matikainen, S., Siren, J., Lehtonen, A., Foster, D., Julkunen, I. and Sareneva, T. (2003) IL-21 in synergy with IL-15 or IL-18 enhances IFN-gamma production in human NK and T cells. J Immunol. 170(11), 5464-9.

    PubMed  CAS  Google Scholar 

  • Takeshita, F., Gursel, I., Ishii, K. J., Suzuki, K., Gursel, M. and Klinman, D. M. (2004) Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9. Semin Immunol. 16(1), 17-22.

    Article  PubMed  CAS  Google Scholar 

  • Thale, C. and Kiderlen, A. F. (2005) Sources of interferon-gamma (IFN-gamma) in early immune response to Listeria monocytogenes. Immunobiology. 210(9), 673-83.

    Article  PubMed  Google Scholar 

  • Tsujimoto, H., Uchida, T., Efron, P. A., Scumpia, P. O., Verma, A., Matsumoto, T., Tschoeke, S. K., Ungaro, R. F., Ono, S., Seki, S., Clare-Salzler, M. J., Baker, H. V., Mochizuki, H., Ramphal, R. and Moldawer, L. L. (2005) Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol. 78(4), 888-97.

    Article  PubMed  CAS  Google Scholar 

  • Walzer, T., Dalod, M., Robbins, S. H., Zitvogel, L. and Vivier, E. (2005) Natural-killer cells and dendritic cells: “l’union fait la force”. Blood. 106(7), 2252-8.

    Article  PubMed  CAS  Google Scholar 

  • Watford, W. T., Hissong, B. D., Bream, J. H., Kanno, Y., Muul, L. and O’Shea, J. J. (2004) Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev. 202, 139-56.

    Article  PubMed  CAS  Google Scholar 

  • Yokoyama, W. M. and Plougastel, B. F. (2003) Immune functions encoded by the natural killer gene complex. Nat Rev Immunol. 3(4), 304-16.

    Article  PubMed  CAS  Google Scholar 

  • Zanoni, I., Foti, M., Ricciardi-Castagnoli, P. and Granucci, F. (2005) TLR-dependent activation stimuli associated with Th1 responses confer NK cell stimulatory capacity to mouse dendritic cells. J Immunol. 175(1), 286-92.

    PubMed  CAS  Google Scholar 

  • Zhang, D., Zhang, G., Hayden, M. S., Greenblatt, M. B., Bussey, C., Flavell, R. A. and Ghosh, S. (2004) A toll-like receptor that prevents infection by uropathogenic bacteria. Science. 303(5663), 1522-6.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this paper

Cite this paper

Lauzon, N.M., Mian, F., Ashkar, A.A. (2007). Toll-like Receptors, Natural Killer Cells and Innate Immunity. In: Lambris, J.D. (eds) Current Topics in Innate Immunity. Advances in Experimental Medicine and Biology, vol 598. Springer, New York, NY. https://doi.org/10.1007/978-0-387-71767-8_1

Download citation

Publish with us

Policies and ethics