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TRAF Proteins in CD40 Signaling

  • Chapter
TNF Receptor Associated Factors (TRAFs)

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 597))

Abstract

The tumor necrosis factor receptor (TNFR) superfamily molecule CD40 is expressed by a wide variety of cell types following activation signals, and constitutively on B lymphocytes, macrophages, and dendritic cells. CD40 signals to cells stimulate kinase activation, gene expression, production of a antibody and a variety of cytokines, expression or upregulation of surface molecules, and protection or promotion of apoptosis. Initial steps in CD40-mediated signal cascades involve the interactions of CD40 with various members of the TNFR-associated factor (TRAF) family of cytoplasmic proteins. This review summarizes current understanding of the nature of these interactions, and how they induce and regulate CD40 functions.

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Authors and Affiliations

  1. Departments of Microbiology and Internal Medicine, Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, 52242, USA

    Gail A. Bishop

  2. Iowa City VAMC, Iowa City, Iowa, 52242, USA

    Gail A. Bishop

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  1. Gail A. Bishop
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  2. Carissa R. Moore
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  3. Ping Xie
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  4. Laura L. Stunz
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  5. Zachary J. Kraus
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  1. Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA

    Hao Wu Ph.D.

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Bishop, G.A., Moore, C.R., Xie, P., Stunz, L.L., Kraus, Z.J. (2007). TRAF Proteins in CD40 Signaling. In: Wu, H. (eds) TNF Receptor Associated Factors (TRAFs). Advances in Experimental Medicine and Biology, vol 597. Springer, New York, NY. https://doi.org/10.1007/978-0-387-70630-6_11

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