Candidate gene, association, linkage, single nucleotide polymorphism, haplotype Polycystic ovary syndrome (PCOS) is considered a common, complex genetic disorder, as are conditions such as schizophrenia, asthma, and type 2 diabetes. Such common diseases, including PCOS, appear to have a complex, multifactorial etiology, wherein a variety of predisposing genes, not just one gene, interact with environmental and lifestyle factors to produce disease. Studies in families demonstrated the heritable nature of PCOS itself as well as the component phenotypes of PCOS. This has led to a large number of population studies attempting to discover genes that influence PCOS using the candidate gene approach.
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© 2007 Springer
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Goodarzi, M.O. (2007). Genetics of PCOS. In: Azziz, R. (eds) The Polycystic Ovary Syndrome: Current Concepts On Pathogenesis And Clinical Care. Endocrine Updates, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69248-7_3
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DOI: https://doi.org/10.1007/978-0-387-69248-7_3
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