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Lymphatic Markers, Tumour Lymphangiogenesis and Lymph Node Metastasis

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Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 135))

Many of the most common human cancers disseminate from the site of primary tumour growth to distant tissues via the vessels and organs of the lymphatic system. In melanomas, cancers of the breast and colorectum, and in head and neck squamous cell carcinomas, early metastasis to lymph nodes is a common clinical finding, and one that is associated with poorer prognosis.Treatments to specifically block dissemination through the lymphatic network could in theory provide an independent therapy for some cancers, or at least an adjunct to existing chemotherapy. However, such a rational basis for the design of treatments is currently hindered by our poor understanding of the fundamental biology of lymphatics, and in particular lymphatic endothelial cell (LEC) biology.

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Authors and Affiliations

  1. MRC Human Immunology Unit, University of Oxford, OX3 9DS, Headington, Oxford, UK

    David G. Jackson B.A.(Mod.), PhD

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  1. David G. Jackson B.A.(Mod.), PhD
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  1. University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, 94143, San Francisco, CA, USA

    Stanley P. L. Leong MD, FACS

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Jackson, D.G. (2007). Lymphatic Markers, Tumour Lymphangiogenesis and Lymph Node Metastasis. In: Leong, S.P.L. (eds) Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy. Cancer Treatment and Research, vol 135. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69219-7_4

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