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Introduction and Future of Site-Directed Spin Labeling of Membrane Proteins

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ESR Spectroscopy in Membrane Biophysics

Part of the book series: Biological Magnetic Resonance ((BIMR,volume 27))

Abstract

One of the most important challenges in the field of structural biology and structural proteomics is the study of membrane proteins. These proteins reside in cell and organelle membranes and govern many important cellular functions, including cell signaling, membrane potential stabilization, energy transduction, pH and cell volume regulation, all of which play critical roles in cancer, heart disease, osteoporosis, cystic diseases, and neurological disorders. These proteins represent more than 50% of all present and future drug targets.

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Authors and Affiliations

  1. Laboratory of Biophysics, Wageningen University, Wageningen, The Netherlands

    Marcus A. Hemminga

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  1. Marcus A. Hemminga
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Hemminga, M.A. (2007). Introduction and Future of Site-Directed Spin Labeling of Membrane Proteins. In: ESR Spectroscopy in Membrane Biophysics. Biological Magnetic Resonance, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-49367-1_1

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  • DOI: https://doi.org/10.1007/978-0-387-49367-1_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25066-3

  • Online ISBN: 978-0-387-49367-1

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