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Intrinsic Versus Extrinsic Vascularization in Tissue Engineering

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Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 585))

Abstract

In-vitro culture of tissues can be regulated by controlled medium administration whereas ex-vivo bioreactors are designed with the capability of providing tissue engineered devices with continuous nutrient support. When these materials or cellular constructs are transferred in vivo they have to rely on processes like interstitial fluid diffusion and blood perfusion. Here recites a core limitation for transfer of tissue engineering models from the in vitro to the in vivo environment. Diffusion is the initial process involved but it can only provide for cell support within a maximum range of 200 μm into the matrix.1–4

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Author information

Authors and Affiliations

  1. Dept. Plastic and Hand Surgery, University of Erlangen, Germany

    Elias Polykandriotis, Raymund. E. Horch, Andreas Arkudas, Apostolos Labanaris, Alexander D. Bach, Jürgen Kopp & Ulrich Kneser

  2. Institute of Pharmacology and Toxicology, University of Erlangen, Germany

    Kay Brune & Andreas Hess

  3. Institute of Materials Sciences, Dept. Glass and Ceramics, University of Erlangen, Germany

    Peter Greil

Authors
  1. Elias Polykandriotis
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  2. Raymund. E. Horch
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  3. Andreas Arkudas
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  4. Apostolos Labanaris
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  5. Kay Brune
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  6. Peter Greil
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  7. Alexander D. Bach
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  8. Jürgen Kopp
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  9. Andreas Hess
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  10. Ulrich Kneser
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Editors and Affiliations

  1. University of Maryland, College Park, MD, 20742, USA

    John P. Fisher

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© 2006 Springer Science+Business Media, LLC

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Polykandriotis, E. et al. (2006). Intrinsic Versus Extrinsic Vascularization in Tissue Engineering. In: Fisher, J.P. (eds) Tissue Engineering. Advances in Experimental Medicine and Biology, vol 585. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34133-0_21

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  • DOI: https://doi.org/10.1007/978-0-387-34133-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-32664-1

  • Online ISBN: 978-0-387-34133-0

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