1. Abstract
Taurine concentration is increased in peripheral blood lymphocytes in a group of depressed subjects. After this observation [3H]taurine transport was measured in lymphocytes of 10 major depression patients (19–60 years old), diagnosed by the criteria of the American Psychiatric Association, with moderate severity as determined by Hamilton Scale for Depression (32 ± 6). The control group comprised 10 subjects (20–56 years old). Taurine transporter and CD4+ (helpers) and CD8+ (cytolytic) T lymphocytes were immunolabeled. No significant differences were observed in immunochemical analyses. CD4+ cells were 53% and CD8+ cells 28% of the total lymphocytes in both controls and patients. Two taurine transport components, high and low affinity, were demonstrated in both groups. Taurine transporter was present in 16% of CD4+ and CD8+ lymphocytes in controls and patients. This preliminary report exhibits the presence of taurine transporter in peripheral blood lymphocytes but no differences were observed between controls and depressed subjects.
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Fazzino, F., Urbina, M., Mata, S., Lima, L. (2006). Taurine Transport and Transporter Localization in Peripheral Blood Lymphocytes of Controls and Major Depression Patients. In: Oja, S.S., Saransaari, P. (eds) Taurine 6. Advances in Experimental Medicine and Biology, vol 583. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-33504-9_48
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DOI: https://doi.org/10.1007/978-0-387-33504-9_48
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