Abstract
This chapter discusses various aspects of coronin phylogeny, structure and function that are of specific interest. Two subfamilies of ancient coronins of unicellular pathogens such as Entamoeba, Trypanosoma, Leishmania and Acanthamoeba as well as of Plasmodium, Babesia, and Trichomonas are presented in the first two sections. Their coronins generally bind to F-actin and apparently are involved in proliferation, locomotion and phagocytosis. However, there are so far no studies addressing a putative role of coronin in the virulence of these pathogens. The following section delineates genetic anomalies like the chimeric coronin-fusion products with pelckstrin homology and gelsolin domains that are found in amoeba. Moreover, most nonvertebrate metazoa appear to encode CRN8, CRN9 and CRN7 representatives (for these coronin symbols see Chapter 2), but in e.g., Drosophila melanogaster and Caenorhabditis elegans a CRN9 is missing. The forth section deals with the evolutionary expansion of vertebrate coronins. Experimental data on the F-actin binding CRN2 of Xenopus (Xcoronin) including a Cdc42/Rac interactive binding (CRIB) motif that is also present in other members of the coronin protein family are discussed. Xenopus laevis represents a case for the expansion of the seven vertebrate coronins due to tetraploidization events. Other examples for a change in the number of coronin paralogs are zebrafish and birds, but (coronin) gene duplication events also occurred in unicellular protozoa. The fifth section of this chapter briefly summarizes three different cellular processes in which CRN4/CORO1A is involved, namely actin-binding, superoxide generation and Ca2+-signaling and refers to the largely unexplored mammalian coronins CRN5/CORO2A and CRN6/CORO2B, the latter binding to vinculin. The final section discusses how, by unveiling the aspects of coronin function in organisms reported so far, one can trace a remarkable evolution and diversity in their indivkdual roles anticipating a rather complex and intricate involvement of coronins in a variety of cellular processes.
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References
Rybakin V, Clemen CS. Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking. Bioessays 2005; 27 (6):625–632.
Uetrecht AC, Bear JE. Coronins: the return of the crown. Trends Cell Biol 2006; 16 (8):421–426.
de Hostos EL. The coronin family of actin-associated proteins. Trends Cell Biol 1999; 9 (9):345–350.
Jayachandran R, Sundaramurthy V, Combaluzier B et al. Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell 2007; 130 (1):37–50.
Baldo ET, Moon EK, Kong HH et al. Acanthamoeba healyi: molecular cloning and characterization of a coronin homologue, an actin-related protein. Exp Parasitol 2005; 110 (2):114–122.
Nayak RC, Sahasrabuddhe AA, Bajpai VK et al. A novel homologue of coronin colocalizes with actin in filament-like structures in Leishmania. Mol Biochem Parasitol 2005; 143 (2):152–164.
Jensen JB, Edgar SA. Possible secretory function of the rhoptries of Eimeria magna during penetration of cultured cells. J Parasitol 1976; 62 (6):988–992.
Miller LH, Aikawa M, Johnson JG et al. Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation. J Exp Med 1979; 149 (1):172–184.
Ryning FW, Remington JS. Effect of cytochalasin D on Toxoplasma gondii cell entry. Infect Immun 1978; 20 (3):739–743.
Tardieux I, Liu X, Poupel O et al. A Plasmodium falciparum novel gene encoding a coronin-like protein which associates with actin filaments. FEBS Lett 1998; 441 (2):251–256.
Figueroa JV, Precigout E, Carcy B et al. Identification of a coronin-like protein in Babesia species. Ann NY Acad Sci 2004; 1026:125–138.
da Costa RF, de Souza W, Benchimol M et al. Trichomonas vaginalis perturbs the junctional complex in epithelial cells. Cell Res 2005; 15 (9):704–716.
Embley TM, Hirt RP. Early branching eukaryotes? Current opinion in genetics & development 1998; 8 (6):624–629.
Rendon-Maldonado JG, Espinosa-Cantellano M, Gonzalez-Robles A et al. Trichomonas vaginalis: in vitro phagocytosis of lactobacilli, vaginal epithelial cells, leukocytes and erythrocytes. Exp Parasitol 1998; 89 (2):241–250.
Bricheux G, Coffe G, Bayle D et al. Characterization, cloning and immunolocalization of a coronin homologue in Trichomonas vaginalis. Eur J Cell Biol 2000; 79 (6):413–422.
Lehker MW, Benchimol M, Alderete JF. Assigning function to putative virulence genes of Trichomonas vaginalis: utility of targeted, selectable gene-replacement. In: Pandalai SG, ed. Recent Res Devel Microbiology 2004; 8:97–119.
Asano S, Mishima M, Nishida E. Coronin forms a stable dimer through its C-terminal coiled coil region: an implicated role in its localization to cell periphery. Genes Cells 2001; 6 (3):225–235.
Mishima M, Nishida E. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertebrate cells. J Cell Sci 1999; 112 (Pt 17):2833–2842.
Hellsten U, Khokha MK, Grammer TC et al. Accelerated gene evolution and subfunctionalization in the pseudotetraploid frog Xenopus laevis. BMC biology 2007; 5:31.
Xavier CP, Rosentreter A, Hofmann A et al. Characterization and functional relevance of coronin 3 isoforms. Submitted for publication.
Nakamura T, Takeuchi K, Muraoka S et al. A neurally enriched coronin-like protein, Clipin C, is a novel candidate for an actin cytoskeleton-cortical membrane-linking protein. J Biol Chem 1999; 274 (19):13322–13327.
Spoerl Z, Stumpf M, Noegel AA et al. Oligomerization, F-actin interaction and membrane association of the ubiquitous mammalian coronin 3 are mediated by its carboxyl terminus. J Biol Chem 2002; 277 (50):48858–48867.
Aspenstrom P. Effectors for the Rho GTPases. Current opinion in cell biology 1999; 11 (1):95–102.
Burbelo PD, Drechsel D, Hall A. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases The Journal of biological chemistry 1995; 270 (49):29071–29074.
Suzuki K, Nishihata J, Arai Y et al. Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motil. FEBS Lett 1995; 364 (3):283–288.
Ferrari G, Langen H, Naito M et al. A coat protein on phagosomes involved in the intracellular survival of mycobacteria. Cell 1999; 97 (4):435–447.
Foger N, Rangell L, Danilenko DM et al. Requirement for coronin 1 in T-lymphocyte trafficking and cellular homeostasis. Science 2006; 313 (5788):839–842.
Nal B, Carroll P, Mohr E et al. Coronin-1 expression in T-lymphocytes: insights into protein function during T-cell development and activation. Int Immunol 2004; 16 (2):231–240.
Okumura M, Kung C, Wong S et al. Definition of family of coronin-related proteins conserved between humans and mice: close genetic linkage between coronin-2 and CD45-associated protein. DNA Cell Biol 1998; 17 (9):779–787.
Grogan A, Reeves E, Keep N et al. Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. J Cell Sci 1997; 110 (Pt 24):3071–3081.
Yan M, Di Ciano-Oliveira C, Grinstein S et al. Coronin function is required for chemotaxis and phagocytosis in human neutrophils. J Immunol 2007; 178 (9):5769–5778.
Didichenko SA, Segal AW, Thelen M. Evidence for a pool of coronin in mammalian cells that is sensitive to PI 3-kinase. FEBS Lett 2000; 485 (2–3):147–152.
David V, Gouin E, Troys MV et al. Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach. J Cell Sci 1998; 111 (Pt 19):2877–2884.
Schuller S, Neefies J, Ottenhoff T et al. Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance. Cell Microbiol 2001; 3 (12):785–793.
Zheng PY, Jones NL. Helicobacter pylori strains expressing the vacuolating cytotoxin interrupt phagosome maturation in macrophages by recruiting and retaining TACO (coronin 1) protein. Cell Microbiol 2003; 5 (1):25–40.
Suzuki K, Takeshita F, Nakata N et al. Localization of CORO1A in the Macrophages Containing Mycobacterium leprae. Acta Histochem Cytochem 2006; 39 (4):107–112.
Yan M, Collins RF, Grinstein S et al. Coronin-1 function is required for phagosome formation. Mol Biol Cell 2005; 16 (7):3077–3087.
Garin J, Diez R, Kieffer S et al. The phagosome proteome: insight into phagosome functions. J Cell Biol 2001; 152 (1):165–180.
Deghmane AE, Soulhine H, Bach H et al. Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. J Cell Sci 2007; 120 (Pt 16):2796–2806.
Gatfield J, Pieters J. Essential role for cholesterol in entry of mycobacteria into macrophages. Science 2000; 288 (5471):1647–1650.
Kaul D, Anand PK, Verma I. Cholesterol-sensor initiates M. tuberculosis entry into human macrophages. Mol Cell Biochem 2004; 258 (1–2):219–222.
Anand PK, Kaul D, Sharma M. Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages. Int J Biochem Cell Biol 2006; 38 (4):600–609.
Itoh S, Suzuki K, Nishihata J et al. The role of protein kinase C in the transient association of p57, a coronin family actin-binding protein, with phagosomes. Biol Pharm Bull 2002; 25 (7):837–844.
Haraldsson MK, Louis-Dit-Sully CA, Lawson BR, et al. The Lupus-related Lmb3 Locus Contains a disease-suppressing Coronin-1A Gene Mutation. Immunity. 2008:In press.
Zaphiropoulos PG, Toftgard R. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. DNA Cell Biol. Dec. 1996; 15 (12):1049–1056.
Drubin DG, Nelson WJ. Origins of cell polarity. Cell. Feb. 9, 1996;84 (3):335–344.
Satterwhite LL, Pollard TD. Cytokinesis. Current opinion in cell biology. Feb. 1992;4 (1):43–52.
Stossel TP. On the crawling of animal cells. Science New York, N.Y. May 21, 1993;260 (5111):1086–1094.
Mitchison TJ, Cramer LP. Actin-based cell motility and cell locomotion. Cell. Feb. 9, 1996;84 (3):371–379.
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Xavier, CP., Eichinger, L., Fernandez, M.P., Morgan, R.O., Clemen, C.S. (2008). Evolutionary and Functional Diversity of Coronin Proteins. In: Clemen, C.S., Eichinger, L., Rybakin, V. (eds) The Coronin Family of Proteins. Subcellular Biochemistry, vol 48. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09595-0_9
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