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Diversity of WD-Repeat proteins

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The Coronin Family of Proteins

Part of the book series: Subcellular Biochemistry ((SCBI,volume 48))

Abstract

The WD-repeat-containing proteins form a very large family that is diverse in both its function and domain structure. Within all these proteins the WD-repeat domains are thought to have two common features: the domain folds into a beta propeller; and the domains form a platform without any catalytic activity on which multiple protein complexes assemble reversibly. The fact that these proteins play such key roles in the formation of protein-protein complexes in nearly all the major pathways and organelles unique to eukaryotic cells has two important implications. It supports both their ancient and proto eukaryotic origins and supports a likely association with many genetic diseases.

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Author information

Authors and Affiliations

  1. BioMolecular Engineering Research Center, College of Engineering, Boston University, 36 Cummington Street, Boston, MA, 02215, USA

    Temple F. Smith

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  1. Temple F. Smith
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Correspondence to Temple F. Smith .

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Editors and Affiliations

  1. Center for Biochemistry, University of Cologne, Cologne, Germany

    Christoph S. Clemen MD  & Ludwig Eichinger PhD  & 

  2. The Scripps Research Institute, La Jolla, California, USA

    Vasily Rybakin PhD

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© 2008 Landes Bioscience and Springer Science+Business Media

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Smith, T.F. (2008). Diversity of WD-Repeat proteins. In: Clemen, C.S., Eichinger, L., Rybakin, V. (eds) The Coronin Family of Proteins. Subcellular Biochemistry, vol 48. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09595-0_3

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