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Positive Interactions with the Microbiota: Probiotics

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GI Microbiota and Regulation of the Immune System

Part of the book series: Advances in Experimental Medicine and Biology ((volume 635))

Abstract

Rigorous research in the field of probiotics is a fairly new phenomenon although first reports about beneficial effects of specific gut bacteria on human health originated already a century ago. A prerequisite for such a scrutiny has been a definition of criteria for probiotics. Recently, novel molecular technologies have characterized both potential targets of probiotic action, like gut microbiota and established and candidate probiotic strains in more detail. We thus propose here revised criteria for selection of probiotics. In addition to several promising clinical studies e.g., in the prevention and treatment of atopic eczema, certain probiotics have been found to maintain intestinal equilibrium by enhancing the gut mucosal barrier via manipulation of expression of several their own and the host’s genes. Introduction of genetic engineering has provided advanced tools to amend probiotics’ properties in the fight against different inflammatory conditions.

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Authors and Affiliations

  1. Department of Paediatrics, University of Turku, PO Box 52, FIN-20521, Turku, Finland

    Marko Kalliomäki, Seppo Salminen & Erika Isolauri

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  1. Marko Kalliomäki
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  2. Seppo Salminen
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  3. Erika Isolauri
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Editors and Affiliations

  1. Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Gary B. Huffnagle PhD

  2. Department of Immunology and Microbiology, Wayne State University, Detroit, Michigan, USA

    Mairi C. Noverr PhD

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Kalliomäki, M., Salminen, S., Isolauri, E. (2008). Positive Interactions with the Microbiota: Probiotics. In: Huffnagle, G.B., Noverr, M.C. (eds) GI Microbiota and Regulation of the Immune System. Advances in Experimental Medicine and Biology, vol 635. Springer, New York, NY. https://doi.org/10.1007/978-0-387-09550-9_5

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