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MicroRNA in Immune Regulation

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Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 410))

Abstract

The immune system protects us from enormously diverse microbial pathogens but needs to be tightly regulated to avoid deleterious immune-mediated inflammation and tissue damage. A wide range of molecular determinants and cellular components work in concert to control the magnitude and duration of a given immune response. In the past decade, microRNAs (miRNAs), a major class of small non-coding RNA species, have been extensively studied as key molecular players in immune regulation. In this chapter, we will discuss how miRNAs function as negative regulators to restrict innate and adaptive immune responses. Moreover, we will review the current reports regarding miRNAs in human immunological diseases. Finally, we will also address the emerging roles of other non-coding RNAs, long non-coding RNAs (lncRNAs) in particular, in the regulation of the immune system.

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Authors and Affiliations

  1. Division of Biological Sciences, University of California, San Diego, La Jolla, CA, 92093, USA

    Cheng-Jang Wu & Li-Fan Lu

  2. Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA

    Li-Fan Lu

  3. Center for Microbiome Innovation, University of California, San Diego, La Jolla, CA, 92093, USA

    Li-Fan Lu

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  1. Cheng-Jang Wu
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  2. Li-Fan Lu
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Correspondence to Li-Fan Lu .

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Editors and Affiliations

  1. Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

    Akihiko Yoshimura

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Wu, CJ., Lu, LF. (2017). MicroRNA in Immune Regulation. In: Yoshimura, A. (eds) Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity. Current Topics in Microbiology and Immunology, vol 410. Springer, Cham. https://doi.org/10.1007/82_2017_65

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