Abstract
Suicide is a leading cause of death, and presently, there is no definitive clinical indicator of future suicide behaviors. Anhedonia, a transdiagnostic symptom reflecting diminished ability to experience pleasure, has recently emerged as a risk factor for suicidal thoughts and behaviors (STBs). This overview, therefore, has the following aims. First, prior research relating anhedonia to STBs will be reviewed, with a particular focus on clarifying whether anhedonia is more closely associated with suicidal thoughts versus behaviors. Second, the National Institute of Mental Health’s Research Domain Criteria Positive Valence Systems provide a useful heuristic to probe anhedonia across different units of analysis, including clinical symptoms, behaviors, neural mechanisms, and molecular targets. Accordingly, anhedonia-related constructs linked to STBs will be detailed as well as promising next steps for future research. Third, although anhedonia is not directly addressed in leading suicide theories, this review will provide potential inroads to explore anhedonia within diathesis-stress and interpersonal suicide frameworks. Last, novel approaches to treat anhedonia as a means of reducing STBs will be examined.
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Acknowledgments
RPA (U01 MH116923, R01 MH119771) and DP (R01 MH126181) were partially supported through funding from the National Institute of Mental Health. RPA and DP also received support through the Tommy Fuss Fund, and DP received support through the American Foundation for Suicide Prevention (YIG-0-145-20). JSK was supported through the Bender-Fishbein Research Award in Child Psychiatry as well as a training fellowship awarded to the Division of Child and Adolescent Psychiatry at Columbia University (T32 MH016434-42). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Dr. Auerbach is an unpaid scientific advisor for Ksana Health. DP and JSK do not have any biomedical financial interests or potential conflicts of interest.
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Auerbach, R.P., Pagliaccio, D., Kirshenbaum, J.S. (2022). Anhedonia and Suicide. In: Pizzagalli, D.A. (eds) Anhedonia: Preclinical, Translational, and Clinical Integration. Current Topics in Behavioral Neurosciences, vol 58. Springer, Cham. https://doi.org/10.1007/7854_2022_358
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