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Pharmacological Treatment of Sleep Disorders and Its Relationship with Neuroplasticity

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Sleep, Neuronal Plasticity and Brain Function

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 25))

Abstract

Sleep and wakefulness are regulated by complex brain circuits located in the brain stem, thalamus, subthalamus, hypothalamus, basal forebrain, and cerebral cortex. Wakefulness and NREM and REM sleep are modulated by the interactions between neurotransmitters that promote arousal and neurotransmitters that promote sleep. Various lines of evidence suggest that sleep disorders may negatively affect neuronal plasticity and cognitive function. Pharmacological treatments may alleviate these effects but may also have adverse side effects by themselves. This chapter discusses the relationship between sleep disorders, pharmacological treatments, and brain plasticity, including the treatment of insomnia, hypersomnias such as narcolepsy, restless legs syndrome (RLS), obstructive sleep apnea (OSA), and parasomnias.

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Authors and Affiliations

  1. Psychiatry and Behavioral Science—Division of Sleep Medicine, Stanford University School of Medicine, Palo Alto, CA, USA

    Vivien C. Abad

  2. Psychiatry and Behavioral Science, and Neurology—Division of Sleep Medicine, Stanford University School of Medicine, Palo Alto, CA, USA

    Christian Guilleminault

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  1. Vivien C. Abad
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  2. Christian Guilleminault
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Correspondence to Christian Guilleminault .

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Editors and Affiliations

  1. Center for Behavior and Neurosciences, University of Groningen, Groningen, The Netherlands

    Peter Meerlo

  2. Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin, USA

    Ruth M. Benca

  3. Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

    Ted Abel

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Abad, V.C., Guilleminault, C. (2015). Pharmacological Treatment of Sleep Disorders and Its Relationship with Neuroplasticity. In: Meerlo, P., Benca, R., Abel, T. (eds) Sleep, Neuronal Plasticity and Brain Function. Current Topics in Behavioral Neurosciences, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2014_365

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