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Genetic Models of Sensorimotor Gating: Relevance to Neuropsychiatric Disorders

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Behavioral Neurogenetics

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 12))

Abstract

Sensorimotor gating, or the ability of a sensory event to suppress a motor response, can be measured operationally via prepulse inhibition (PPI) of the startle response. PPI is deficient in schizophrenia patients as well as other neuropsychiatric disorders, can be measured across species, and has been used widely as a translational tool in preclinical neuropharmacological and genetic research. First developed to assess drug effects in pharmacological and developmental models, PPI has become one of the standard behavioral measures in genetic models of schizophrenia and other neuropsychiatric disorders that exhibit PPI deficits. In this chapter we review the literature on genetic models of sensorimotor gating and discuss the utility of PPI as a tool in phenotyping mutant mouse models. We highlight the approaches to genetic mouse models of neuropsychiatric disease, discuss some of the important caveats to these approaches, and provide a comprehensive table covering the more recent genetic models that have evaluated PPI.

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Acknowledgments

This work was supported by grants from the National Institute of Mental Health (R01MH042228, R01MH052885, R01MH091407) and by the Veterans Affairs VISN 22 Mental Illness Research, Education, and Clinical Center.

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Authors and Affiliations

  1. Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093-0804, USA

    Susan B. Powell & Mark A. Geyer

  2. Research Service, VA San Diego Healthcare System, San Diego, CA, USA

    Susan B. Powell & Mark A. Geyer

  3. Department of Neuroscience, Genentech Inc, 1 DNA Way, South San Francisco, CA, 94080-4990, USA

    Martin Weber

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  1. Susan B. Powell
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Correspondence to Susan B. Powell .

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  1. , Dep of Pharmacology and Therapeutics, School of Pharmacy, College Rd, Cork, 30, Ireland

    John F. Cryan

  2. , Department of Psychiatry and Psychothera, University of Würzburg, Füchsleinstrasse 15, Würzburg, 97080, Germany

    Andreas Reif

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Powell, S.B., Weber, M., Geyer, M.A. (2011). Genetic Models of Sensorimotor Gating: Relevance to Neuropsychiatric Disorders. In: Cryan, J., Reif, A. (eds) Behavioral Neurogenetics. Current Topics in Behavioral Neurosciences, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2011_195

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