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Endoplasmic Reticulum-associated Protein Degradation in Plant Cells

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The Plant Endoplasmic Reticulum

Part of the book series: Plant Cell Monographs ((CELLMONO,volume 4))

Abstract

The endoplasmic reticulum (ER) is equipped with a quality control function that retains misfoldedand unassembled proteins and allows only structurally mature polypeptides to be transported to their finaldestination. The retained proteins are eventually retro-translocated to the cytosol and destroyed by a processcalled endoplasmic reticulum-associated degradation (ERAD). Besides being involved in the degradation ofaberrant polypeptides, the ERAD pathway is also used to regulate cellular functions and is exploited bysome plant and bacterial toxins to reach the cytosol after internalization by target cells. After summarizingthe general characteristics of the ERAD pathway, we describe the features of known plant ERAD substratesand of the plant degradative machinery, highlighting the role of protein disposal in the response to ERstress.

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Acknowledgments

We wish to thank Myriam Ermonval for critical reading of the manuscript. Work in the authors' laboratory was supported by MIUR-FIRB grant RBNE01TYZF and by the UK BBSRC and The Wellcome Trust.

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  1. Istituto di Biologia e Biotecnologia Agraria, Consiglio Nazionale delle Ricerche, Via Bassini 15, 20133, Milan, Italy

    Aldo Ceriotti

  2. Department of Biological Sciences, University of Warwick, CV4 7AL, Coventry, UK

    Lynne M. Roberts

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  1. Aldo Ceriotti
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Correspondence to Aldo Ceriotti .

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David G. Robinson

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Ceriotti, A., Roberts, L.M. (2006). Endoplasmic Reticulum-associated Protein Degradation in Plant Cells. In: Robinson, D.G. (eds) The Plant Endoplasmic Reticulum. Plant Cell Monographs, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7089_066

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